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Results for "

PTK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BRK (4) FAK (5) AAK1 (3) ADC Antibody (1) Akt (2) AMPK (1) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (7) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (5) Aurora Kinase (2) Autophagy (1) Bacterial (9) Bcr-Abl (1) Btk (1) CaMK (2) CDK (3) COX (1) Cyclin G-associated Kinase (GAK) (2) E3 Ligase Ligand-Linker Conjugates (7) EGFR (6) Ephrin Receptor (1) ERK (2) Ferroptosis (2) FGFR (1) IGF-1R (1) IRAK (1) Isotope-Labeled Compounds (2) Itk (1) JAK (1) Ligands for Target Protein for PROTAC (1) LIM Kinase (LIMK) (2) MAP4K (2) MAPKAPK2 (MK2) (1) MELK (1) Microtubule/Tubulin (1) MMP (1) Mps1 (1) mTOR (1) NF-κB (1) p38 MAPK (1) PDGFR (1) PERK (1) Phospholipase (2) PKA (1) PKC (1) Polo-like Kinase (PLK) (1) PROTAC Linkers (1) PROTACs (9) Reference Standards (5) RET (18) ROR (1) Salt-inducible Kinase (SIK) (2) Small Interfering RNA (siRNA) (12) Src (4) STAT (1) Target Protein Ligand-Linker Conjugates (1) TNF Receptor (1) Tyrosinase (2) ULK (3) VEGFR (6) Wee1 (1) Wnt (2) β-catenin (3)
By Research Areas:	Cancer (61) Cardiovascular Disease (1) Infection (10) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (2)
Oligonucleotides:	Aptamers (3) Rat Pre-designed siRNA Sets (4) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (4) siRNAs (12)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: FAK BRK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14865

Omadacycline Maximum Cited Publications 32 Publications Verification PTK 0796; Amadacycline	Bacterial Antibiotic	Infection
Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

HY-P99829

Cofetuzumab pelidotin PF-06647020; ABBV-647; h6M24-vc0101	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Cofetuzumab pelidotin (PF-06647020) is a *PTK7*-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC₅₀ of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .

HY-P99828

Cofetuzumab PF-06523435; hu24	ADC Antibody RET PERK ROR	Cancer
Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting *PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK*7 expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer .

HY-110244

Tilfrinib	BRK	Cancer
Tilfrinib (compound 4f) is a potent and selective *Brk/PTK6* inhibitor with an IC₅₀ value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour .

HY-10203

Vatalanib 10+ Cited Publications PTK787; ZK-222584; CGP-79787	VEGFR	Cancer
Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC₅₀ of 37 nM.

HY-14865B

Omadacycline tosylate Maximum Cited Publications 32 Publications Verification PTK 0796 tosylate; Amadacycline tosylate	Bacterial Antibiotic	Infection
Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

HY-171830

MS105 YX39-105	PROTACs Tyrosinase Apoptosis	Cancer
MS105 (YX39-105) is an orally active and selective protein tyrosine kinase 6 (PTK6) (BRK) PROTAC degrader. MS105 recruits VHL E3 ligase via a VHL ligand moiety, promotes PTK6 ubiquitination and proteasomal degradation, inhibits the proliferation and migration of breast cancer cells, and induces apoptosis. MS105 shows potential for use in breast cancer research .

HY-124625

BI-4464	FAK Target Protein Ligand-Linker Conjugates	Infection Cancer
BI-4464 is a highly selective, ATP competitive *PTK2/FAK* protein kinase inhibitor with an IC₅₀ value of 17 nM. BI-4464 is a FAK (HY-43760) ligand and linker conjugate. BI-4464 can be used to construct proteolysis targeting chimeras (PROTACs), such as PROTAC FAK degrader 4 (HY-178467). PROTAC FAK degrader 4 is a highly potent and selective FAK PROTAC degrader .

HY-148065

FMF-06-098-1	PROTACs Wee1 CDK AAK1 ULK MELK Itk IRAK Ephrin Receptor FGFR MAP4K p38 MAPK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

HY-N0616

Trifolirhizin	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB	Infection Metabolic Disease Inflammation/Immunology Cancer
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .

HY-12018

Vatalanib dihydrochloride 10+ Cited Publications PTK787 dihydrochloride; ZK-222584 dihydrochloride; CGP-797870 dihydrochloride	VEGFR Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Vatalanib dihydrochloride (PTK787 dihydrochloride) is a BBB-permeable VEGFR2/KDR inhibitor with an IC₅₀ of 37 nM.

HY-14865C

Omadacycline hydrochloride Maximum Cited Publications 32 Publications Verification PTK0796 hydrochloride; Amadacycline hydrochloride	Bacterial Antibiotic	Infection
Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

HY-111546

BI-3663 1 Publications Verification	PROTACs FAK	Cancer
BI-3663 is a highly selective *PTK2/FAK* PROTAC (DC₅₀=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC₅₀ of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 (HY-124625) linked to Pomalidomide (HY-10984) with a linker . Anti-cancer activity .

HY-N2506

Ginsenoside Ra1	Others	Cardiovascular Disease
Ginsenoside Ra1 is a component from ginseng, inhibits protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation .

HY-123919

TL13-112 2 Publications Verification	PROTACs Anaplastic lymphoma kinase (ALK)	Cancer
TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC₅₀ value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, *PTK2* and RPS6KA1 with IC₅₀ values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib?(HY-15656) and the Cereblon ligand of Pomalidomide (HY-10984) .

HY-122582

TL13-12	PROTACs Anaplastic lymphoma kinase (ALK)	Cancer
TL13-12 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC₅₀ value of 0.69 nM. TL13-12 also prompts the degradation of additional kinases including Aurora A, FER, *PTK2, and RPS6KA1* with IC₅₀ values of 13.5 nM, 5.74 nM, 18.4 nM, and 65 nM, respectively. TL13-12 is comprised of the conjugation of TAE684 (HY-10192) and the Cereblon ligand of Pomalidomide (HY-10984) .

HY-148061

DB1113	PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)	Cancer
DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity .

HY-21291

SU-4313	PDGFR EGFR IGF-1R	Cancer
SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC₅₀s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation .

HY-101960A

Tyrphostin A51 AG-183	EGFR	Cancer
Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ ³H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation .

HY-N4201

β-Hydroxyisovalerylshikonin	EGFR Src	Cancer
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC₅₀s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells .

HY-171770

dAurAB5	PROTACs Aurora Kinase AAK1 Cyclin G-associated Kinase (GAK) Mps1 FAK	Cancer
dAurAB5 is a dual Aurora-A (DC₅₀ = 8.8 nM) and Aurora-B (DC₅₀ = 6.1 nM) PROTAC degrader. dAurAB5 induces degradation of Aurora-A and Aurora-B, reduces N-Myc levels, and decreases viability in IMR32 neuroblastoma cells. dAurAB5 downregulates the levels of AAK1, PTK2, GAK, and TTK. dAurAB5 can be used to study cancers such as neuroblastoma. (Pink: TTK ligand 2: HY-168542, Blue: Thalidomide-O-COOH: HY-103597, Black: 6-Aminocaproic acid: HY-B0236) .

HY-14865S

Omadacycline-d9 PTK 0796-d₉; Amadacycline-d₉	Bacterial Isotope-Labeled Compounds	Others
Omadacycline-d9 (PTK 0796-d9; Amadacycline-d9) is the deuterium labeled Omadacycline (HY-14865) that can be used as the internal standard for the analysis of Omadacycline .

HY-115514A

BRK inhibitor P21d hydrochloride	BRK	Cancer
BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC₅₀ of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC₅₀ of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models .

HY-148063

DB0614	PROTACs AAK1 Aurora Kinase CaMK CDK Ferroptosis Salt-inducible Kinase (SIK) LIM Kinase (LIMK) ULK	Metabolic Disease
DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity .(Blue: Thalidomide-4-OH (HY-103596), Black: linker, Pink: FLT3-IN-17 (HY-148070))

HY-160488

PTK7/β-catenin-IN-1	β-catenin	Cancer
PTK7/β-catenin-IN-1 (compound 01065) is a potent *PTK7/β-catenin* inhibitor with an IC₅₀ of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research .

HY-103097

ST271	Phospholipase	Others
ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC₅₀s of 6.7 and 9 μM, respectively.

HY-122664

XMU-MP-2	BRK Apoptosis STAT ERK Akt	Cancer
XMU-MP-2 is a selective *BRK/PTK6* inhibitor with an IC₅₀ of 5.4 nM. XMU-MP-2 inhibits the proliferation of BRK-positive breast cancer cells and induces apoptosis. XMU-MP-2 is applicable to breast cancer-related research .

HY-RS11403

PTK6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTK6 Human Pre-designed siRNA Set A contains three designed siRNAs for PTK6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTK6 Human Pre-designed siRNA Set A PTK6 Human Pre-designed siRNA Set A

HY-P3743

p60c-src Substrate	Src Others	Others
p60c-src Substrate is an efficient and specific substrate for p60c-src protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

HY-176198

BI-0319	PROTACs FAK	Cancer
BI-0319 is a selective PTK2/FAK PROTAC degrader. BI-0319 can reduce cancer cells viability inhibit proliferation and invasion. BI-0319 can be used for the research of cancer, such as liver cancer . (Structure Note: Pink: PTK2/FAK ligand (HY-43760); Blue: VHL ligand (HY-125845); Black: linker (HY-140189); VHL ligand-Linker: (HY-103602A))

HY-178460

*BRK/PTK6-IN-1*	BRK Akt MMP	Cancer
BRK/PTK6-IN-1 (Compound 51) is a highly efficient and selective BRK inhibitor (IC₅₀ = 3.37 nM, K_d = 44 nM). BRK/PTK6-IN-1 can reduce MMP-9 protein expression and inhibit IGF-1 induced AKT phosphorylation in MDA-MB-231 cells. BRK/PTK6-IN-1 significantly inhibits migration, invasion, and colony formation but does not affect cell proliferation. BRK/PTK6-IN-1 is often used in the research of breast cancer and other cancers .

HY-14865BR

Omadacycline tosylate (Standard) PTK 0796 tosylate (Standard); Amadacycline tosylate (Standard)	Reference Standards Bacterial Antibiotic	Infection
Omadacycline (tosylate) (Standard) is the analytical standard of Omadacycline (tosylate). This product is intended for research and analytical applications. Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

HY-110272

Vatalanib succinate PTK787 succinate; ZK-222584 succinate; CGP-79787 succinate	VEGFR	Cancer
Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC₅₀s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively .

HY-130422

Tos-PEG4-t-butyl ester Tos-PEG4-Boc	PROTAC Linkers	Cancer
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC₅₀ of 18 nM .

HY-112395

BTO-1	Polo-like Kinase (PLK)	Others
BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications .

HY-18237

KX1-004	Src	Others
KX1-004 is a potent and non-ATP competitive *Src-PTK* inhibitor with an IC₅₀ of 40 μM. KX1-004 protects the cochlea from hazardous noise and prevents noise-induced hearing loss (NIHL) .

HY-RS11402

PTK2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTK2B Human Pre-designed siRNA Set A contains three designed siRNAs for PTK2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTK2B Human Pre-designed siRNA Set A PTK2B Human Pre-designed siRNA Set A

HY-122844B

Ifebemtinib tosylate BI-853520 tosylate; IN-10018 tosylate	FAK	Cancer
Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective *PTK2* kinase inhibitor. Ifebemtinib (tosylate) demonstrates anti-tumor activity. Ifebemtinib (tosylate) inhibits FAK autophosphorylation in prostate carcinoma cells. Ifebemtinib (tosylate) can inhibit spheroid formation and orthotopic tumor growth in vivo. Ifebemtinib (tosylate) can be studied in anticancer research such as solid tumors, breast cancer, and malignant pleural mesothelioma .

HY-101960

(Z)-Tyrphostin A51 (Z)-AG-183	EGFR	Others
(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ ³H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation .

HY-160489

PTK7/β-catenin-IN-2	β-catenin Wnt	Cancer
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of *PTK7/β-catenin*. It inhibits the binding of PTK7 to β-catenin (IC₅₀: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC₅₀ of 157.1 μM .

HY-160493

PTK7/β-catenin-IN-6	Wnt β-catenin	Cancer
PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC) .

HY-139660

*PROTAC PTK6 ligand-1*	Ligands for Target Protein for PROTAC	Cancer
PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation . PROTAC PTK6 ligand-1 can be used in the synthesis of ARD-61 (HY-139659) .

HY-RS11401

Ptk2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk2 Rat Pre-designed siRNA Set A Ptk2 Rat Pre-designed siRNA Set A

HY-RS11400

Ptk2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk2 Mouse Pre-designed siRNA Set A Ptk2 Mouse Pre-designed siRNA Set A

HY-RS17543

Ptk7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptk7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk7 Mouse Pre-designed siRNA Set A Ptk7 Mouse Pre-designed siRNA Set A

HY-RS11399

PTK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTK2 Human Pre-designed siRNA Set A contains three designed siRNAs for PTK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTK2 Human Pre-designed siRNA Set A PTK2 Human Pre-designed siRNA Set A

HY-RS11404

PTK7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTK7 Human Pre-designed siRNA Set A contains three designed siRNAs for PTK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTK7 Human Pre-designed siRNA Set A PTK7 Human Pre-designed siRNA Set A

HY-RS24001

Ptk7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptk7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk7 Rat Pre-designed siRNA Set A Ptk7 Rat Pre-designed siRNA Set A

HY-RS24000

Ptk6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptk6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk6 Rat Pre-designed siRNA Set A Ptk6 Rat Pre-designed siRNA Set A

HY-RS20473

Ptk2b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptk2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk2b Mouse Pre-designed siRNA Set A Ptk2b Mouse Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L016

Protein Tyrosine Kinase Compound Library

1,578 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1,578 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L196

Protein Kinase Compound Library

4,332 compounds

Protein Kinases (PTKs) are a class of phosphotransferases that phosphorylate proteins. Protein kinases participate in many signal transduction pathways including those involved with growth, differentiation, and cell division. Protein kinase not only plays an important role in the process of cell activation, but also its abnormal expression is closely related to the pathogenesis of many diseases. So far, the protein kinase family has become one of the most important drug targets. The most common drug targets include ALK, B-Raf, BCR-Abl, EGFR, and VEGFR.

MCE designs a unique collection of 4,332 bioactive compounds targeting protein kinases, which is an important tool for the development of drug targeting protein kinases.

Cat. No.	Product Name	Target	Research Area

HY-P3743

p60c-src Substrate	Src Peptides	Others
p60c-src Substrate is an efficient and specific substrate for p60c-src protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

HY-P3787

Ac-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2	Peptides	Metabolic Disease
Ac-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2 is the SH2 domain ligand. SH2 domains participate in protein tyrosine kinase (PTK)-mediated cellular signal .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99829

Cofetuzumab pelidotin PF-06647020; ABBV-647; h6M24-vc0101	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Cofetuzumab pelidotin (PF-06647020) is a *PTK7*-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC₅₀ of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .

HY-P99828

Cofetuzumab PF-06523435; hu24	ADC Antibody RET PERK ROR	Cancer
Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting *PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK*7 expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0616

Trifolirhizin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Trifolium pratense Linn. Sophora flavescens Aiton Plants Other Flavonoids Inflammation/Immunology Disease Research Fields Source Classification Cancer	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .

HY-N2506

Ginsenoside Ra1	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Others
Ginsenoside Ra1 is a component from ginseng, inhibits protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation .

HY-N4201

β-Hydroxyisovalerylshikonin	Quinones Classification of Application Fields Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Disease Research Fields Boraginaceae Cancer Source Classification	EGFR Src
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC₅₀s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells .

Species:	Human (26) Rhesus Macaque (1) Rat (2) Mouse (5) Cynomolgus (1) Rabbit (1)
Tag:	His (18) Strep (1) Tag Free (5) Avi (5) GST (11) Fc (5)
Source:	HEK293 (16) sf9 insect cells (4) P. pastoris (1) Sf9 insect cells (10) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705867

	PTK2B Protein, Human (Active, Biotinylated, sf9, Avi) PTK2B; PTK2B protein tyrosine kinase 2 beta; FAK2, protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; CADTK; CAKB; PTK; PYK2; RAFTK; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; PKB; FAK2; FADK2	Human	sf9 insect cells

HY-P705866

	PTK2B Protein, Human (277a.a, sf9) PTK2B; PTK2B protein tyrosine kinase 2 beta; FAK2, protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; CADTK; CAKB; PTK; PYK2; RAFTK; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; PKB; FAK2; FADK2	Human	sf9 insect cells

HY-P703617

	PTK9L Protein, Human PTK9L	Human	E. coli
	PTK9L Protein, Human is the recombinant human-derived PTK9L, expressed by E. coli , with tag Free labeled tag. ,

HY-P703618

	PTK9L Protein, Human (His, Strep) PTK9L	Human	E. coli
	PTK9L Protein, Human (His, Strep) is the recombinant human-derived PTK9L, expressed by E. coli , with Strep, His labeled tag. ,

HY-P78398

	PTK7 Protein, Human (HEK293, His) CCK-4; PTK7	Human	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (HEK293, His-Avi) is the recombinant human-derived PTK7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P703967

	PTK7 Protein, Human (HEK293, hFc) CCK-4; PTK7	Human	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (HEK293, hFc) is the recombinant human-derived PTK7 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P703966

	PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi) CCK-4; PTK7	Mouse	HEK293
	Ptk7 Protein is a cell surface receptor that plays a crucial role in regulating cell migration and tissue development. Dysregulation of Ptk7 Protein has been associated with various diseases, including cancer and developmental disorders. Targeting Ptk7 Protein may offer potential therapeutic interventions in these conditions by modulating cell migration, inhibiting tumor growth, and promoting normal tissue development. PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi) is the recombinant mouse-derived PTK7 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

HY-P703970

	PTK7 Protein, Human (Biotinylated, HEK293, His, Avi) CCK-4; PTK7	Human	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived PTK7 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

HY-P705077

	PTK7 Protein, Human (Biotinylated, HEK293, Fc-Avi) CCK-4; PTK7	Human	HEK293

HY-P702950

	PTK9L Protein, Human (sf9, GST) PTK9L; hA6RP; TWF2; MSTP011	Human	Sf9 insect cells
	PTK9L Protein, Human (sf9, GST) is the recombinant human-derived PTK9L, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P75470

	*Brk/PTK6 Protein, Human (sf9, GST)* Protein-tyrosine kinase 6; SRC-related intestinal kinase; PTK6; Sik	Human	Sf9 insect cells
	Brk is a nonreceptor tyrosine protein kinase that regulates signaling pathways critical for epithelial tissue differentiation, normal maintenance, and tumor growth. Context-dependent functions involve a variety of substrates, including RNA-binding proteins, transcription factors, and signaling molecules. Brk/PTK6 Protein, Human (sf9, GST) is the recombinant human-derived Brk protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P702726

	*Brk/PTK6 Protein, Human (Active, sf9, His, GST)* PTK6; PTK6 protein tyrosine kinase 6; protein-tyrosine kinase 6; BRK; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kinase BRK; FLJ42088;	Human	Sf9 insect cells
	Brk is a nonreceptor tyrosine protein kinase that regulates signaling pathways critical for epithelial tissue differentiation, normal maintenance, and tumor growth. Context-dependent functions involve a variety of substrates, including RNA-binding proteins, transcription factors, and signaling molecules. Brk/PTK6 Protein, Human (sf9, His, GST) is the recombinant human-derived Brk/PTK6, expressed by Sf9 insect cells, with His, GST labeled tag. The total length of Brk/PTK6 Protein, Human (sf9, His, GST) is 450 a.a..

HY-P78619

	PTK7 Protein, Rat (HEK293, His) 1 Publications Verification PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Rat	HEK293
	The PTK7 protein is predicted to mediate cell adhesion molecule binding and play critical roles in a variety of cellular processes, including actin cytoskeleton reorganization and regulation of the canonical Wnt signaling pathway. It affects animal organ development, axis elongation, and epithelial morphogenesis. PTK7 Protein, Rat (HEK293, His) is the recombinant rat-derived PTK7 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P78761

	PTK7 Protein, Mouse (HEK293, His) 1 Publications Verification PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Mouse	HEK293
	Ptk7 Protein is a cell surface receptor that plays a crucial role in regulating cell migration and tissue development. Dysregulation of Ptk7 Protein has been associated with various diseases, including cancer and developmental disorders. Targeting Ptk7 Protein may offer potential therapeutic interventions in these conditions by modulating cell migration, inhibiting tumor growth, and promoting normal tissue development. PTK7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PTK7 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P78603

	PTK7 Protein, Rabbit (HEK293, His) PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Rabbit	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived PTK7 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P78618

	PTK7 Protein, Rat (HEK293, Fc) PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Rat	HEK293
	The PTK7 protein is predicted to mediate cell adhesion molecule binding and play critical roles in a variety of cellular processes, including actin cytoskeleton reorganization and regulation of the canonical Wnt signaling pathway. It affects animal organ development, axis elongation, and epithelial morphogenesis. PTK7 Protein, Rat (HEK293, Fc) is the recombinant rat-derived PTK7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704963

	PTK7 Protein, Mouse (HEK293, Fc) PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Mouse	HEK293

HY-P78573

	PTK7 Protein, Cynomolgus/Rhesus macaque (HEK293, His) PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Cynomolgus;Rhesus Macaque	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Cynomolgus/Rhesus macaque (HEK293, His) is the recombinant cynomolgus, Rhesus Macaque-derived PTK7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77167

	PTK9 Protein, Human Twinfilin-1; Protein A6; Protein tyrosine kinase 9; TWF1	Human	E. coli
	PTK9, an actin-binding protein, regulates motility and morphological processes by inhibiting actin polymerization and capping the barbed ends of filaments. It plays a crucial role in clathrin-mediated endocytosis and the distribution of endocytic organelles. PTK9 interacts with G-actin, capping protein (CP), and possibly TWF2 and phosphoinositides, particularly PI(4,5)P2, which down-regulates its activity. Additionally, it interacts with ACTG1. PTK9 Protein, Human is the recombinant human-derived PTK9 protein, expressed by E. coli , with tag free.

HY-P702929

	MLK3 Protein, Human (Active, sf9, His-GST) MLK3; PTK1; SPRK; MAP3K11	Human	Sf9 insect cells
	MLK3 Protein, Human (Active, sf9, GST) is the recombinant human-derived MLK3, expressed by Sf9 insect cells , with N-GST labeled tag. ,

HY-P705804

	DDR1 Protein, Human (sf9) CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE	Human	sf9 insect cells

HY-P705876

	RON/MSPR Protein, Human (sf9) Macrophage-stimulating protein receptor; p185-Ron; MST1R; PTK8	Human	sf9 insect cells

HY-P704093

	DDR1 Protein, Human (HEK293, Fc) CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE	Human	HEK293
	The DDR1 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that tightly regulates cell attachment and affects extracellular matrix processes. Upon collagen binding, DDR1 initiates a signaling cascade involving SRC, activating MAP kinase. DDR1 Protein, Human (HEK293, Fc) is the recombinant human-derived DDR1 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P77168

	PTK9 Protein, Human (His-GST) Twinfilin-1; Protein A6; Protein tyrosine kinase 9; TWF1	Human	E. coli
	PTK9, an actin-binding protein, regulates motility and morphological processes by inhibiting actin polymerization and capping the barbed ends of filaments. It plays a crucial role in clathrin-mediated endocytosis and the distribution of endocytic organelles. PTK9 interacts with G-actin, capping protein (CP), and possibly TWF2 and phosphoinositides, particularly PI(4,5)P2, which down-regulates its activity. Additionally, it interacts with ACTG1. PTK9 Protein, Human (His-GST) is the recombinant human-derived PTK9 protein, expressed by E. coli , with N-His, N-GST labeled tag.

HY-P77180

	RON/MSPR Protein, Human (HEK293, His, solution) Macrophage-stimulating protein receptor; p185-Ron; MST1R; PTK8	Human	HEK293
	RON/MSPR protein is a receptor tyrosine kinase that transduces signals by binding to MST1 ligand and regulates cell survival, migration, and differentiation. Ligand binding induces RON autophosphorylation, creating docking sites for downstream molecules. RON/MSPR Protein, Human (HEK293, His, solution) is the recombinant human-derived RON/MSPR protein, expressed by HEK293 , with C-His labeled tag.

HY-P77180A

	RON/MSPR Protein, Human (HEK293, C-His) Macrophage-stimulating protein receptor; p185-Ron; MST1R; PTK8	Human	HEK293
	RON/MSPR protein is a receptor tyrosine kinase that transduces signals by binding to MST1 ligand and regulates cell survival, migration, and differentiation. Ligand binding induces RON autophosphorylation, creating docking sites for downstream molecules. RON/MSPR Protein, Human (HEK293, C-His) is the recombinant human-derived RON/MSPR, expressed by HEK293, with C-10*His labeled tag.

HY-P705604

	RON/MSPR Protein, Human (Active, sf9, GST) Macrophage-stimulating protein receptor; p185-Ron; MST1R; PTK8	Human	Sf9 insect cells

HY-P77639

	DDR1 Protein, Mouse (HEK293, His) HGK2; MCK-10; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; DDR1; CD167; EDDR1; PTK3; CD167a; DDR; EC 2.7.10; EC 2.7.10.1; ENTRK4	Mouse	HEK293
	The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR1, expressed by HEK293, with C-6*His labeled tag.

HY-P72856

	Brk Protein, Mouse (Active, sf9, His-GST) Protein-tyrosine kinase 6; SRC-related intestinal kinase; PTK6; Sik	Mouse	Sf9 insect cells
	Brk protein is a non-receptor tyrosine protein kinase that regulates signaling pathways critical for epithelial differentiation and tumor growth.Its context-dependent functions involve phosphorylating substrates such as RNA-binding proteins, transcription factors, and signaling molecules.Brk Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Brk protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P705128

	DDR1 Protein, Human (Biotinylated, HEK293, His-Avi) CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE	Human	HEK293

HY-P705576

	FRK Protein, Human (Active, sf9, GST) Tyrosine-protein kinase FRK; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; PTK5, RAK	Human	Sf9 insect cells

HY-P71821

	PTK7 Protein, Human (P.pastoris, His) CCK 4; CCK-4; Colon carcinoma kinase 4; Inactive tyrosine-protein kinase 7; Tyrosine-protein kinase-like 7	Human	P. pastoris
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (P.pastoris, His) is the recombinant human-derived PTK7 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P701682

	FAK1 Protein, Human (Active, sf9, GST) PTK2; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK	Human	Sf9 insect cells
	FAK1 is a nonreceptor protein tyrosine kinase that coordinates multiple cellular processes. FAK1 Protein, Human (sf9, GST) is the recombinant human-derived FAK1 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P706088

	PTK2B Protein, Human (Active, 331a.a, sf9) Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Related adhesion focal tyrosine kinase; RAFTK; FAK2; PYK2; RAFTK	Human	Sf9 insect cells

HY-P706032

	DDR1 Protein, Human (Active, 433a.a, sf9, GST) Epithelial discoidin domain-containing receptor 1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; HGK2; Mammary carcinoma kinase 10; MCK-10; Protein-tyrosine kinase 3A; Protein-tyrosine kinase RTK-6; TRK E; Tyrosine kinase DDR; Tyrosine-protein kinase CAK; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE	Human	Sf9 insect cells

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Cat. No.	Product Name	Chemical Structure

HY-14865S

Omadacycline-d9
Omadacycline-d9 (PTK 0796-d9; Amadacycline-d9) is the deuterium labeled Omadacycline (HY-14865) that can be used as the internal standard for the analysis of Omadacycline .

HY-W701071

Vatalanib-d4
Vatalanib-d₄ (PTK787-d₄; ZK-222584-d₄; CGP-79787-d₄) is the deuterium labeled Vatalanib (HY-10203). Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC₅₀ of 37 nM.

Host:	Mouse (22) Rabbit (13)
Reactivity:	Human (35) Rat (3) Mouse (6) Rabbit (1) Dog (1) Pig (1)
Application:	IHC-P (20) ICC/IF (12) IF-Tissue (2) IP (4) IHC-F (1) WB (29) FC (5) ELISA (18)
Isotype:	IgG (12) IgG1 (10) IgG/Kappa (1) IgG2a (4) IgG2b (2)
Conjugation:	Non-conjugated (35) Biotin (5)
Clonality:	Monoclonal (19) Monoclonal Antibody (3) Recombinant (7)
Modification:	Phosphorylated (1) Unmodified (22)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84568

	PYK2 Antibody (YA4265) PKB; PTK; CAKB; FAK2; FRNK; PTK2B	WB, IHC-P, ELISA	Human
	PYK2 Antibody (YA4265) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PYK2.

HY-P84568A

	PYK2 Antibody (YA4265)(PBS only) PKB; PTK; CAKB; FAK2; FRNK; PTK2B	WB, IHC-P, ELISA	Human
	PYK2 Antibody (YA4265) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PYK2.

HY-P84320

	FRK Antibody (YA4017) GTK; RAK; PTK5	WB, ELISA	Human
	FRK Antibody (YA4017) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FRK.

HY-P81458

	*Brk/PTK6 Antibody (YA1203)* PTK6; BRK; Protein-tyrosine kinase 6; Breast tumor kinase; Tyrosine-protein kinase BRK	IHC-P	Human
	Brk/PTK6 Antibody (YA1203) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Brk/PTK6.

HY-P85066

	*Brk/PTK6 Antibody (YA4758)* PTK6; BRK; Protein-tyrosine kinase 6; Breast tumor kinase; Tyrosine-protein kinase BRK	WB, ELISA	Human
	Brk/PTK6 Antibody (YA4758) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Brk/PTK6.

HY-P84534

	CCK-4 Antibody (YA4231) CCK4; PTK7	WB, IHC-P, ELISA	Human
	CCK-4 Antibody (YA4231) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCK-4.

HY-P84558

	*Brk/PTK6 Antibody (YA4255)* BRK; FLJ42088	WB, ELISA	Human
	Brk/PTK6 Antibody (YA4255) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Brk/PTK6.

HY-P81458A

	*Brk/PTK6 Antibody (YA1203)(PBS only)* PTK6; BRK; Protein-tyrosine kinase 6; Breast tumor kinase; Tyrosine-protein kinase BRK	IHC-P	Human
	Brk/PTK6 Antibody (YA1203) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Brk/PTK6.

HY-P84320A

	FRK Antibody (YA4017)(PBS only) GTK; RAK; PTK5	WB, ELISA	Human
	FRK Antibody (YA4017) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FRK.

HY-P84534A

	CCK-4 Antibody (YA4231)(PBS only) CCK4; PTK7	WB, IHC-P, ELISA	Human
	CCK-4 Antibody (YA4231) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCK-4.

HY-P84558A

	*Brk/PTK6 Antibody (YA4255)(PBS only)* BRK; FLJ42088	WB, ELISA	Human
	Brk/PTK6 Antibody (YA4255) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Brk/PTK6.

HY-P84486

	RON Antibody (YA4183) PTK8; CD136; CDw136; MST1R	WB, ELISA	Human
	RON Antibody (YA4183) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RON.

HY-P85584

	FAK Antibody (YA5276) FADK 1; FADK; FAK 1; FAK 1; FAK related non kinase polypeptide; FAK1; FAK1_HUMAN; Focal adhesion kinase 1; Focal adhesion kinase 1; Focal adhesion Kinase; Focal adhesion kinase isoform FAK Del33; Focal adhesion kinase related nonkinase; FRNK; p125FAK; pp125FAK; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; Protein tyrosine kinase 2; Protein Tyrosine Kinase Cytoplasmic; Protein Tyrosine Kinase Cytoplasmic; Protein-tyrosine kinase 2; PTK 2; PTK 2; PTK2; PTK2 protein tyrosine kinase 2; PTK2 protein tyrosine kinase 2.	WB, ICC/IF	Human
	FAK Antibody (YA5276) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FAK.

HY-P84486A

	RON Antibody (YA4183)(PBS only) PTK8; CD136; CDw136; MST1R	WB, ELISA	Human
	RON Antibody (YA4183) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RON.

HY-P87350

	TWF1/Twinfilin-1 Antibody (YA7033) A6 antibody; A6 protein tyrosine kinase antibody; MGC105817 antibody; MGC23788 antibody; MGC41876 antibody; Protein A6 antibody; Protein tyrosine kinase 9 antibody; PTK9 antibody; PTK9 protein tyrosine kinase 9 antibody; TWF 1 antibody	WB, ICC/IF, IHC-P, FC	Human
	TWF1/Twinfilin-1 Antibody (YA7033) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TWF1/Twinfilin-1.

HY-P87350A

	TWF1/Twinfilin-1 Antibody (YA7033)(PBS only) A6 antibody; A6 protein tyrosine kinase antibody; MGC105817 antibody; MGC23788 antibody; MGC41876 antibody; Protein A6 antibody; Protein tyrosine kinase 9 antibody; PTK9 antibody; PTK9 protein tyrosine kinase 9 antibody; TWF 1 antibody	WB, ICC/IF, IHC-P, FC	Human
	TWF1/Twinfilin-1 Antibody (YA7033) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TWF1/Twinfilin-1.

HY-P85347

	FRK Antibody (YA5039) FRK; PTK5; RAK; Tyrosine-protein kinase FRK; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5	IHC-P, ELISA	Human
	FRK Antibody (YA5039) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FRK.

HY-P85347A

	FRK Antibody (YA5039)(PBS only) FRK; PTK5; RAK; Tyrosine-protein kinase FRK; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5	IHC-P, ELISA	Human
	FRK Antibody (YA5039) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FRK.

HY-P81384

	RON Antibody (YA1129) MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD136	IHC-P	Human
	RON Antibody (YA1129) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RON.

HY-P810691

	RON Antibody (YA9944) MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD136	WB, IHC-P, ICC/IF, IP, FC	Human
	RON Antibody (YA1129) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RON.

HY-P85354

	Ron Antibody (YA5046) MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD antigen CD136	WB, IHC-P, ICC/IF, IP, IF-Tissue	Human
	Ron Antibody (YA5046) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Ron.

HY-P81384A

	RON Antibody (YA1129)(PBS only) MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD136	IHC-P	Human
	RON Antibody (YA1129) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RON.

HY-P83492

	MLK3 Antibody (YA3237) MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase	WB, ICC/IF	Human
	MLK3 Antibody (YA3237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MLK3.

HY-P83492A

	MLK3 Antibody (YA3237)(PBS only) MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase	WB, ICC/IF	Human
	MLK3 Antibody (YA3237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MLK3.

HY-P85079

	CCK-4 Antibody (YA4771) PTK7; CCK4; Inactive tyrosine-protein kinase 7; Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7	WB, IHC-P, ICC/IF, ELISA	Human
	CCK-4 Antibody (YA4771) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CCK-4.

HY-P80877

	PYK2 Antibody (YA682) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P	Human
	PYK2 Antibody (YA682) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PYK2.

HY-P85341

	PYK2 Antibody (YA5033) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P, ICC/IF, IF-Tissue, FC, IHC-F	Human, Mouse, Rat
	PYK2 Antibody (YA5033) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to PYK2.

HY-P85462

	PYK2 Antibody (YA5154) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB	Human, Mouse, Dog, Pig, Rabbit
	PYK2 Antibody (YA5154) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PYK2.

HY-P86140

	PYK2 Antibody (YA5832) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PYK2 Antibody (YA5832) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PYK2.

HY-P86571

	FAK Antibody (YA6263) PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	FAK Antibody (YA6263) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAK.

HY-P85119

	DDR1 Antibody (YA4811) DDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; Epithelial discoidin domain-containing receptor 1; Epithelial discoidin domain receptor 1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; HGK2;	WB, ELISA	Human
	DDR1 Antibody (YA4811) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DDR1.

HY-P85157

	FAK Antibody (YA4849) PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK	WB, ICC/IF, FC, ELISA	Human
	FAK Antibody (YA4849) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FAK.

HY-P80877A

	PYK2 Antibody (YA682)(PBS only) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P	Human
	PYK2 Antibody (YA682) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PYK2.

HY-P80816

	Phospho-FAK (Tyr576) Antibody (YA199) PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK	WB	Human, Mouse
	Phospho-FAK (Tyr576) Antibody (YA199) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-FAK (Tyr576).

HY-P80816A

	Phospho-FAK (Tyr576) Antibody (YA199)(PBS only) PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK	WB	Human, Mouse
	Phospho-FAK (Tyr576) Antibody (YA199) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-FAK (Tyr576).