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Pyridoxal 5'-phosphate hydrate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (6) Bacterial (5) Biochemical Assay Reagents (7) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (23) Environmental Pollutants (2) ERK (6) Ferrochelatase (1) GABA Receptor (2) Insecticide (2) Isotope-Labeled Compounds (3) Liposome (2) LPL Receptor (1) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (1) P2Y Receptor (1) Phosphatase (1) Potassium Channel (2) Reference Standards (8) Reverse Transcriptase (3) Serine Racemase (SR) (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (4) Infection (5) Inflammation/Immunology (3) Metabolic Disease (18) Neurological Disease (19)
Oligonucleotides:	Phospholipids (2)

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Biochemical Assay Reagents

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Sodium Phosphate Cotransporter Glucose-6-Phosphate Isomerase (GPI) Carbamoyl Phosphate Synthetase (CPS) PIKfyve PI4P5K

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1744

Pyridoxal phosphate 4 Publications Verification Pyridoxal 5′-phosphate; Pyridoxyl phosphate	Reverse Transcriptase Endogenous Metabolite ERK Amyloid-β	Neurological Disease Metabolic Disease Cancer
Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

HY-W011727A

Pyridoxal 5'-phosphate monohydrate 4 Publications Verification Pyridoxal phosphate monohydrate	Endogenous Metabolite Amyloid-β ERK	Neurological Disease Metabolic Disease Cancer
Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP) .

HY-W011727S

Pyridoxal Phosphate-d3 Pyridoxal 5'-phosphate-d₃	Endogenous Metabolite Amyloid-β ERK	Neurological Disease Metabolic Disease Cancer
Pyridoxal Phosphate-d₃ is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-W027446

Pyridoxal hydrochloride 1 Publications Verification	Endogenous Metabolite	Neurological Disease Metabolic Disease
Pyridoxal hydrochloride, the hydrochloride form of Pyridoxal (HY-107469), is a newly developed neuroprotective agent. Pyridoxal hydrochloride is one of the major forms of vitamin B6. Pyridoxal hydrochloride is solvolyzed in methanol to form pyridoxal monomethylacetal. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine. Pyridoxal hydrochloride is proming for research of carpal tunnel syndrome (CTS) .

HY-W011727

Pyridoxal 5'-phosphate hydrate 4 Publications Verification Pyridoxal phosphate hydrate	Endogenous Metabolite Amyloid-β ERK	Neurological Disease Metabolic Disease Cancer
Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-N8157

4'-O-Methylpyridoxine 1 Publications Verification	Others	Cardiovascular Disease Neurological Disease
4'-O-Methylpyridoxine is an orally active antivitamin B6 compound found in Ginkgo biloba seeds and leaves. 4'-O-Methylpyridoxine inhibits pyridoxal kinase. 4'-O-Methylpyridoxine reduces brain pyridoxal-5'-phosphate (PLP) levels, decreases gamma-aminobutyric acid/glutamate (GABA/Glu) ratio. 4'-O-Methylpyridoxine increases plasma levels of pyridoxal-5'-phosphate and pyridoxal. 4'-O-Methylpyridoxine induces hyperactivity, convulsions, pathological tissue changes, organ damage in rodent brain and heart .

HY-P2985

Alanine aminotransferase, Porcine heart	Endogenous Metabolite	Metabolic Disease
Alanine aminotransferase, Porcine heart is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate .

HY-114758

Pyridoxal isonicotinoyl hydrazone 4 Publications Verification	Biochemical Assay Reagents Ferrochelatase	Cardiovascular Disease
Pyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase (FECH) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia) ^[5] .

HY-B1746

Pyridoxamine 5′-phosphate	Endogenous Metabolite	Neurological Disease
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of Pyridoxal 5'-?phosphate monohydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .

HY-B1500

2,2,2-Trichloroethanol 2 Publications Verification	Potassium Channel Endogenous Metabolite	Neurological Disease
2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K_2P channels TREK-1 (KCNK2) and TRAAK (KCNK4) .

HY-B1744R

Pyridoxal phosphate (Standard) Pyridoxal 5′-phosphate (Standard); Pyridoxyl phosphate (Standard)	Reference Standards Reverse Transcriptase Endogenous Metabolite	Neurological Disease
Pyridoxal phosphate (Standard) is the analytical standard of Pyridoxal phosphate. This product is intended for research and analytical applications. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

HY-107469

*Pyridoxal* 1 Publications Verification Pyridoxaldehyde	Endogenous Metabolite	Neurological Disease Metabolic Disease
Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS) .

HY-N7113

Squalane	Environmental Pollutants	Cancer
Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-A0104K

HPMC (Type II,Viscosity:3mPa.s) Hypromellose (Type II,Viscosity:3mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:3mPa.s); Celacol HPM 5000 (Type II,Viscosity:3mPa.s)	Environmental Pollutants Biochemical Assay Reagents	Others
HPMC (Type II, Viscosity: 3 mPa.s) is a nonionic polymer prepared via synthetic modification of cellulose. As a hydrophilic matrix material, HPMC prolongs drug release through non-Fickian diffusion, which includes the diffusion of drugs in the hydrated matrix and the polymer relaxation process .

HY-148009

Cardiolipin (16:0/18:1/16:0/18:1) sodium 16:0-18:1 Cardiolipin sodium	Biochemical Assay Reagents	Others
Cardiolipin (16:0/18:1/16:0/18:1) (16:0-18:1 Cardiolipin) sodium is a di-saturated mitochondrial-specific anionic phospholipid sodium salt containing the long-chain fatty acid palmitic acid (HY-N0830) and the monounsaturated fatty acid oleic acid (HY-N1446). Cardiolipin (16:0/18:1/16:0/18:1) sodium undergoes in-source fragmentation via diglyceride (DG)-H₂O fragment formation and (DG-H₂O) fragment loss pathways. Cardiolipin (16:0/18:1/16:0/18:1) sodium can be used in the synthesis of lipid nanodiscs for application in in situ mass spectrometry .

HY-107469R

Pyridoxal (Standard) 1 Publications Verification Pyridoxaldehyde (Standard)	Endogenous Metabolite Reference Standards	Neurological Disease Metabolic Disease
Pyridoxal (Standard) is the analytical standard of Pyridoxal. This product is intended for research and analytical applications. Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS)[1][2][3].

HY-145539

1,2-Dipalmitoyl-sn-glycero-3-PS sodium	Liposome	Others
1,2-Dipalmitoyl-sn-glycero-3-PS sodium is a phosphatidylserine phospholipid. 1,2-Dipalmitoyl-sn-glycero-3-PS sodium is used for the preparation of phospholipid bilayers .

HY-W094712

Potassium oxalate monohydrate	Biochemical Assay Reagents	Others
Potassium oxalate monohydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-107469S1

Pyridoxal-d3 Pyridoxaldehyde-d₃	Endogenous Metabolite	Others
Pyridoxal-d₃ is the deuterium labeled Pyridoxal .

HY-N3394

Lecanoric acid	Others	Infection
Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .

HY-15377

DL-Gabaculine hydrochloride	GABA Receptor	Neurological Disease
DL-Gabaculine hydrochloride is a neurotoxin that irreversibly inhibits bacterial pyridoxal phosphate linked γ-aminobutyric acid-α-ketoglutaric acid transaminase with a K_i of 2.86 μM .

HY-107469S

Pyridoxal-d3 hydrochloride Pyridoxaldehyde-d3 hydrochloride	Isotope-Labeled Compounds	Others
Pyridoxal-d₃ (hydrochloride) is the deuterium labeled Pyridoxal hydrochloride .

HY-B1744S

Pyridoxal phosphate-d5	Isotope-Labeled Compounds Reverse Transcriptase Endogenous Metabolite	Neurological Disease
Pyridoxal phosphate-d₅ is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia .

HY-P2876

Tryptophanase	Bacterial	Others
Tryptophanase is a zymogen-converting enzyme and inducible enzyme that can convert its inactive precursor form into an active enzyme without additional polypeptide synthesis. In Escherichia coli K12, tryptophanase functions as an inducible enzyme, and its induction kinetics are similar to those of β-galactosidase. Tryptophanase catalyzes the conversion of L-tryptophan to indole .

HY-W011727AR

Pyridoxal 5'-phosphate monohydrate (Standard) Pyridoxal phosphate monohydrate (Standard)	Reference Standards Endogenous Metabolite Amyloid-β ERK	Neurological Disease Metabolic Disease Cancer
Pyridoxal 5'-phosphate (monohydrate) (Standard) is the analytical standard of Pyridoxal 5'-phosphate (monohydrate). This product is intended for research and analytical applications. Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-N7113R

Squalane (Standard)	Reference Standards Others	Cancer
Squalane (Standard) is the analytical standard of Squalane. This product is intended for research and analytical applications. Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-W588249

Sabinene hydrate	Bacterial Endogenous Metabolite	Infection
Sabinene hydrate is a volatile organic compound of a bicyclic monoterpene alcohol. Sabinene hydrate, as a plant secondary metabolite, is naturally present in various plants and their essential oils. Sabinene hydrate exhibits broad-spectrum but varying-intensity antibacterial activity, with the greatest sensitivity to Gram-positive bacteria, especially Bacillus subtilis (MIC = 0.0312 mg/mL) and Staphylococcus aureus (MIC = 0.0625 mg/mL). Sabinene hydrate also shows certain sensitivity to Escherichia coli and Candida albicans, with MIC values of 0.125 mg/mL for both. Sabinene hydrate can be used in the research of the ecological functions of plant defense substances .

HY-W745771

D-Penicillamine-d6	Isotope-Labeled Compounds Biochemical Assay Reagents	Metabolic Disease
D-Penicillamine-d₆ is the deuterium labeled L-Penicillamine (HY-116073). L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength .

HY-P991210

Efzimfotase alfa ALXN-1850	Phosphatase	Cardiovascular Disease
Efzimfotase alfa (ALXN-1850) is enzyme replacement therapy agent targeting the deficiency of tissue-nonspecific alkaline phosphatase (TNSALP). Efzimfotase alfa functions by hydrolyzing the substrates of TNSALP, reducing the concentrations of substrates such as inorganic pyrophosphate (PPi) and pyridoxal 5′-phosphate (PLP). Efzimfotase alfa is promising for research of hypophosphatasia (HPP) .

HY-W011727R

Pyridoxal 5'-phosphate hydrate (Standard) Pyridoxal phosphate hydrate (Standard)	Endogenous Metabolite Reference Standards Amyloid-β ERK	Neurological Disease Metabolic Disease Cancer
Pyridoxal 5'-phosphate (hydrate) (Standard) is the analytical standard of Pyridoxal 5'-phosphate (hydrate) (HY-W011727). This product is intended for research and analytical applications. Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-13682A

Mifamurtide sodium hydrate MTP-PE sodium hydrate; L-MTP-PE sodium hydrate; CGP 19835 sodium hydrate	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Mifamurtide (MTP-PE; CGP 19835) sodium hydrate is the sodium hydrate of mifamurtide. Mifamurtide is a nonspecific immunomodulator that acts by stimulating immune responses by activating macrophages and monocytes. Mifamurtide is a specific ligand for NOD2 and is used as an insulin sensitizer and may also be used in osteosarcoma research .

HY-E70570

Glutamate decarboxylase	GABA Receptor	Metabolic Disease
Glutamate decarboxylase is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (CO2). Many gut microbes can metabolize glutamate via their Glutamate decarboxylase in a pyridoxal-5′-phosphate (PLP) dependent manner .

HY-123202

MRS2603	P2Y Receptor	Cancer
MRS2603 is a pyridoxal derivative. MRS2603 antagonized both P2Y1 and P2Y13 receptors .

HY-W027446R

Pyridoxal hydrochloride (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease Metabolic Disease
Pyridoxal hydrochloride (Standard) is the analytical standard of Pyridoxal hydrochloride. This product is intended for research and analytical applications. Pyridoxal hydrochloride, the hydrochloride form of Pyridoxal (HY-107469), is a newly developed neuroprotective agent. Pyridoxal hydrochloride is one of the major forms of vitamin B6. Pyridoxal hydrochloride is solvolyzed in methanol to form pyridoxal monomethylacetal. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine. Pyridoxal hydrochloride is proming for research of carpal tunnel syndrome (CTS) .

HY-162508

KSK-104	Bacterial	Infection
KSK-104 has potent antibacterial activity against Mycobacterium tuberculosis (MIC=0.78 μM). The role of KSK-104 is mainly involved in the synthesis and recovery pathways of pyridoxal 5'-phosphate (PLP), PLP-dependent enzymes and oxidative stress networks. KSK-104, as a candidate molecule for novel anti-tuberculosis drugs, can be used to develop research against drug-resistant mycobacterium tuberculosis .

HY-162652

HSR-IN-1	Serine Racemase (SR)	Neurological Disease
HSR-IN-1 (Compound 28) is an effective hSR (human serine racemase) inhibitor. In the presence of the cofactor Pyridoxal 5'-phosphate monohydrate (HY-W011727A), HSR-IN-1 has a K_d value of 5.4 μM and an IC₅₀ of 18.3 μM for hSR, while the IC₅₀ of HSR-IN-1 alone is 4.7 μM. HSR-IN-1 can be used for research on central nervous system diseases .

HY-B1746R

Pyridoxamine 5′-phosphate (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease
Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .

HY-47272A

N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate	Nucleoside Antimetabolite/Analog	Cancer
N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate is the hydrate of N6-Benzoyl-9-β-D-arabinofuranosyladenine (HY-47272). N6-Benzoyl-9-β-D-arabinofuranosyladenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

HY-B1500R

2,2,2-Trichloroethanol (Standard)	Reference Standards Potassium Channel Endogenous Metabolite	Neurological Disease
2,2,2-Trichloroethanol (Standard) is the analytical standard of 2,2,2-Trichloroethanol. This product is intended for research and analytical applications. 2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4) .

HY-111598

4-Phospho-D-erythronate	Drug Intermediate Bacterial	Infection
4-Phospho-D-erythronate is a Ribose 5-phosphate isomerase inhibitor, intermediate in pyridoxal 5'-phosphate synthesis in some bacteria, and substrate for 4PE dehydrogenase (PdxB) in select proteobacteria .

HY-E70894

α,γ-Homocysteinase, Trichomonas vaginalis	Endogenous Metabolite	Metabolic Disease
α,γ-Homocysteinase, Trichomonas vaginalis is a pyridoxal-5’-phosphate dependent enzyme. α,γ-Homocysteinase, Trichomonas vaginalis is a mutant of homocysteinase from Trichomonas vaginalis encoded by mgl1 gene, containing three point mutations, such as; Phe47Leu, Asp172Glu, Ser308Tyr. α,γ-Homocysteinase, Trichomonas vaginalis can metabolize homocysteine into α-keto butyrate, hydrogen sulfide and ammonia.

HY-P2985B

Alanine aminotransferase, Human (E.coli)	Endogenous Metabolite	Metabolic Disease
Alanine aminotransferase, Human (E.coli) is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate .

HY-E71076

(5-Formylfuran-3-yl)Methyl phosphate transaminase	Biochemical Assay Reagents	Others
(5-Formylfuran-3-yl)methyl phosphate transaminase (EC 2.6.1.108), characterized from the archaebacterium Methanocaldococcus jannaschii, participates in the biosynthesis of the cofactor methanofuran. Requires pyridoxal 5'-phosphate.

HY-W791994A

BVL3572S	Bacterial	Inflammation/Immunology
BVL3572S, a hydroxamic acid derivative, exhibits potent bactericidal activity against Mycobacterium tuberculosis (Mtb) with a MIC₉₀ of 1.7 µM. BVL3572S inhibits pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA to kill Mtb. BVL3572S can be used for tuberculosis (TB) research .

HY-126915

CNK-6004	Drug Metabolite	Metabolic Disease
CNK-6004 is a Montirelin hydrate (NS-3) (HY-19154) metabolite .

HY-E71319

β-Methylphenylalanine transaminase	Biochemical Assay Reagents	Others
β-Methylphenylalanine transaminase (EC 2.6.1.107) requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.

HY-124655

S1PL-IN- 2	LPL Receptor	Inflammation/Immunology
S1PL-IN-2 (Compound 28) is a potent sphingosine-1-phosphate lyase (S1PL) inhibitor with an IC₅₀ of 120 nM. S1PL-IN-2 shows an IC₅₀ of 230 nM on HEK293 cells. S1PL-IN-2 block the conversion of Vitamin B6 into the active pyridoxal-4-phosphate cofactor required for S1P lyase activity. S1PL-IN-2 can be used for the researches of inflammation and immunology, such as rheumatoid arthritis .

HY-W460727

Boron sodium oxide tetrahydrate	Insecticide	Infection
Boron sodium oxide (tetrahydrate) is an alkaline salt. Boron sodium oxide (tetrahydrate) can be used as an insecticide, a flame retardant, and an agricultural micronutrient .

HY-E70938

L-Tyrosine Decarboxylase Apoenzyme, Streptococcus faecalis	Endogenous Metabolite	Metabolic Disease
L-Tyrosine Decarboxylase Apoenzyme, Streptococcus faecalis (EC 4.1.1.25), is a carboxyl lyase capable of cleaving carbon-carbon bonds. L-Tyrosine Decarboxylase Apoenzyme participates in tyrosine metabolism and alkaloid biosynthesis. L-Tyrosine Decarboxylase Apoenzyme uses a cofactor—pyridoxal phosphate. L-Tyrosine Decarboxylase Apoenzyme has one substrate, L-tyrosine, and two products: tyramine and carbon dioxide.

HY-P2825A

L-Tyrosine Decarboxylase, Streptococcus faecalis	Endogenous Metabolite	Metabolic Disease
L-Tyrosine Decarboxylase, Streptococcus faecalis (EC 4.1.1.25), is a carboxyl lyase capable of cleaving carbon-carbon bonds. L-Tyrosine Decarboxylase Apoenzyme participates in tyrosine metabolism and alkaloid biosynthesis. L-Tyrosine Decarboxylase Apoenzyme uses a cofactor—pyridoxal phosphate. L-Tyrosine Decarboxylase Apoenzyme has one substrate, L-tyrosine, and two products: tyramine and carbon dioxide.

Cat. No.	Product Name	Target	Research Area	Image

HY-P991210

Efzimfotase alfa ALXN-1850	Phosphatase	Cardiovascular Disease
Efzimfotase alfa (ALXN-1850) is enzyme replacement therapy agent targeting the deficiency of tissue-nonspecific alkaline phosphatase (TNSALP). Efzimfotase alfa functions by hydrolyzing the substrates of TNSALP, reducing the concentrations of substrates such as inorganic pyrophosphate (PPi) and pyridoxal 5′-phosphate (PLP). Efzimfotase alfa is promising for research of hypophosphatasia (HPP) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1744

Pyridoxal phosphate 4 Publications Verification Pyridoxal 5′-phosphate; Pyridoxyl phosphate	Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Reverse Transcriptase Endogenous Metabolite ERK Amyloid-β
Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

HY-W011727A

Pyridoxal 5'-phosphate monohydrate 4 Publications Verification Pyridoxal phosphate monohydrate	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Amyloid-β ERK
Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP) .

HY-W027446

Pyridoxal hydrochloride 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Pyridoxal hydrochloride, the hydrochloride form of Pyridoxal (HY-107469), is a newly developed neuroprotective agent. Pyridoxal hydrochloride is one of the major forms of vitamin B6. Pyridoxal hydrochloride is solvolyzed in methanol to form pyridoxal monomethylacetal. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine. Pyridoxal hydrochloride is proming for research of carpal tunnel syndrome (CTS) .

HY-W011727

Pyridoxal 5'-phosphate hydrate 4 Publications Verification Pyridoxal phosphate hydrate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Amyloid-β ERK
Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-N8157

4'-O-Methylpyridoxine 1 Publications Verification	Alkaloids Structural Classification Ginkgoaceae Classification of Application Fields Other Diseases Pyridine Alkaloids Plants Ginkgo biloba Disease Research Fields Source Classification	Others
4'-O-Methylpyridoxine is an orally active antivitamin B6 compound found in Ginkgo biloba seeds and leaves. 4'-O-Methylpyridoxine inhibits pyridoxal kinase. 4'-O-Methylpyridoxine reduces brain pyridoxal-5'-phosphate (PLP) levels, decreases gamma-aminobutyric acid/glutamate (GABA/Glu) ratio. 4'-O-Methylpyridoxine increases plasma levels of pyridoxal-5'-phosphate and pyridoxal. 4'-O-Methylpyridoxine induces hyperactivity, convulsions, pathological tissue changes, organ damage in rodent brain and heart .

HY-B1746

Pyridoxamine 5′-phosphate	Alkaloids Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of Pyridoxal 5'-?phosphate monohydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .

HY-B1500

2,2,2-Trichloroethanol 2 Publications Verification	Natural Products Endogenous metabolite Source Classification	Potassium Channel Endogenous Metabolite
2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K_2P channels TREK-1 (KCNK2) and TRAAK (KCNK4) .

HY-B1744R

Pyridoxal phosphate (Standard) Pyridoxal 5′-phosphate (Standard); Pyridoxyl phosphate (Standard)	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Reverse Transcriptase Endogenous Metabolite
Pyridoxal phosphate (Standard) is the analytical standard of Pyridoxal phosphate. This product is intended for research and analytical applications. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

HY-107469

*Pyridoxal* 1 Publications Verification Pyridoxaldehyde	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS) .

HY-N7113

Squalane	Structural Classification Natural Products Animals Classification of Application Fields Marine natural products Disease Research Fields Source Classification Cancer	Environmental Pollutants
Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-107469R

Pyridoxal (Standard) 1 Publications Verification Pyridoxaldehyde (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Pyridoxal (Standard) is the analytical standard of Pyridoxal. This product is intended for research and analytical applications. Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS)[1][2][3].

HY-N3394

Lecanoric acid	Infection Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification	Others
Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .

HY-W011727AR

Pyridoxal 5'-phosphate monohydrate (Standard) Pyridoxal phosphate monohydrate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Amyloid-β ERK
Pyridoxal 5'-phosphate (monohydrate) (Standard) is the analytical standard of Pyridoxal 5'-phosphate (monohydrate). This product is intended for research and analytical applications. Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-N7113R

Squalane (Standard)	Structural Classification Natural Products Animals Source Classification	Reference Standards Others
Squalane (Standard) is the analytical standard of Squalane. This product is intended for research and analytical applications. Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-W588249

Sabinene hydrate	Structural Classification Other Monoterpenes Juniperus communis L. Cupressaceae Terpenoids Plants Source Classification	Bacterial Endogenous Metabolite
Sabinene hydrate is a volatile organic compound of a bicyclic monoterpene alcohol. Sabinene hydrate, as a plant secondary metabolite, is naturally present in various plants and their essential oils. Sabinene hydrate exhibits broad-spectrum but varying-intensity antibacterial activity, with the greatest sensitivity to Gram-positive bacteria, especially Bacillus subtilis (MIC = 0.0312 mg/mL) and Staphylococcus aureus (MIC = 0.0625 mg/mL). Sabinene hydrate also shows certain sensitivity to Escherichia coli and Candida albicans, with MIC values of 0.125 mg/mL for both. Sabinene hydrate can be used in the research of the ecological functions of plant defense substances .

HY-W011727R

Pyridoxal 5'-phosphate hydrate (Standard) Pyridoxal phosphate hydrate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards Amyloid-β ERK
Pyridoxal 5'-phosphate (hydrate) (Standard) is the analytical standard of Pyridoxal 5'-phosphate (hydrate) (HY-W011727). This product is intended for research and analytical applications. Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-W027446R

Pyridoxal hydrochloride (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Pyridoxal hydrochloride (Standard) is the analytical standard of Pyridoxal hydrochloride. This product is intended for research and analytical applications. Pyridoxal hydrochloride, the hydrochloride form of Pyridoxal (HY-107469), is a newly developed neuroprotective agent. Pyridoxal hydrochloride is one of the major forms of vitamin B6. Pyridoxal hydrochloride is solvolyzed in methanol to form pyridoxal monomethylacetal. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine. Pyridoxal hydrochloride is proming for research of carpal tunnel syndrome (CTS) .

HY-B1746R

Pyridoxamine 5′-phosphate (Standard)	Alkaloids Human Gut Microbiota Metabolites Pyridine Alkaloids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .

HY-B1500R

2,2,2-Trichloroethanol (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Potassium Channel Endogenous Metabolite
2,2,2-Trichloroethanol (Standard) is the analytical standard of 2,2,2-Trichloroethanol. This product is intended for research and analytical applications. 2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4) .

HY-N14147

Sarmentogenin	Structural Classification Tetracyclic Triterpenoids Animals Terpenoids Source Classification	Others
Sarmentogenin is a cardenolide aglycone can be found in rhodexin A and Chrysolina herbacea .

Species:	Human (1) Mouse (1)
Tag:	His (1) GST (1)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P79342

	Pyridoxal Kinase Protein, Human (GST) Pyridoxal kinase; PDXK; Pyridoxine kinase; C21orf124; C21orf97; PKH; PNK	Human	E. coli
	Pyridoxal Kinase Protein catalyzes vitamin B6 vitamer phosphorylation—converting pyridoxal (PL), pyridoxine (PN), and pyridoxamine (PM) into active forms: pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP), and pyridoxamine 5'-phosphate (PMP) (Probable). PLP serves as the active cofactor in more than 140 enzymatic reactions. Pyridoxal Kinase Protein, Human (His) is the recombinant human-derived Pyridoxal Kinase protein, expressed by E. coli , with N-GST labeled tag.

HY-P71768

	PLP phosphatase Protein, Mouse (P.pastoris, His) Pdxp; Cin; Plp; Plpp; Pyridoxal phosphate phosphatase; PLP phosphatase; Chronophin	Mouse	P. pastoris
	The PLP phosphatase protein plays a dual role as a pyridoxal phosphate (PLP) phosphatase and a protein serine phosphatase. Its enzymatic activity in vitamin B6 metabolism involves the dephosphorylation of PLP, PNP and PMP. PLP phosphatase Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived PLP phosphatase protein, expressed by P. pastoris , with N-His labeled tag.

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HY-W011727S

Pyridoxal Phosphate-d3

Pyridoxal Phosphate-d₃ is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-107469S1

Pyridoxal-d3
Pyridoxal-d₃ is the deuterium labeled Pyridoxal .

HY-107469S

Pyridoxal-d3 hydrochloride
Pyridoxal-d₃ (hydrochloride) is the deuterium labeled Pyridoxal hydrochloride .

HY-B1744S

Pyridoxal phosphate-d5
Pyridoxal phosphate-d₅ is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia .

HY-W745771

D-Penicillamine-d6
D-Penicillamine-d₆ is the deuterium labeled L-Penicillamine (HY-116073). L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength .

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HY-P810301

	PDXDC1 Antibody LP8165; PDXD1; Pyridoxal-dependent decarboxylase domain containing 1	WB	Human, Mouse, Rat
	PDXDC1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PDXDC1.

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Cat. No.	Product Name		Classification

HY-148009

Cardiolipin (16:0/18:1/16:0/18:1) sodium 16:0-18:1 Cardiolipin sodium		Phospholipids
Cardiolipin (16:0/18:1/16:0/18:1) (16:0-18:1 Cardiolipin) sodium is a di-saturated mitochondrial-specific anionic phospholipid sodium salt containing the long-chain fatty acid palmitic acid (HY-N0830) and the monounsaturated fatty acid oleic acid (HY-N1446). Cardiolipin (16:0/18:1/16:0/18:1) sodium undergoes in-source fragmentation via diglyceride (DG)-H₂O fragment formation and (DG-H₂O) fragment loss pathways. Cardiolipin (16:0/18:1/16:0/18:1) sodium can be used in the synthesis of lipid nanodiscs for application in in situ mass spectrometry .

HY-145539

1,2-Dipalmitoyl-sn-glycero-3-PS sodium		Phospholipids
1,2-Dipalmitoyl-sn-glycero-3-PS sodium is a phosphatidylserine phospholipid. 1,2-Dipalmitoyl-sn-glycero-3-PS sodium is used for the preparation of phospholipid bilayers .

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Pyridoxal 5'-phosphate hydrate

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