24 Results for "

RBL

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "RBL" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-N2344
CAS No.: 103883-03-0
Synonyms: Proanthocyanidin A1
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca 2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .
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2
2 Cited Publications
Cat. No.: HY-112390A
CAS No.: 726695-51-8
Purity:  98.15%
Target:  

Syk 5-HT Receptor

Research Areas:  

Inflammation/Immunology

Syk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect .
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1
1 Cited Publications
Cat. No.: HY-12504
CAS No.: 245747-08-4
Purity:  98.47%
Synonyms: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide
Target:  

CRAC Channel

Research Areas:  

Others

Pyr6 is a selective store operated calcium entry (SOCE) inhibitor with an IC50 of 0.49 μM. Pyr6 displays 37-fold higher potency for RBL SOCE than for TRPC3 ROCE .
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1
1 Cited Publications
Cat. No.: HY-113776
CAS No.: 92693-02-2
Purity:  ≥99.0%
Target:  

Lipoxygenase

Research Areas:  

Inflammation/Immunology

15(S)-HETRE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.
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Cat. No.: HY-N2252
CAS No.: 51020-86-1
Synonyms: (+)-Licarin A
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression .
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Cat. No.: HY-105024
CAS No.: 103141-09-9
Purity:  99.25%
Target:  

Lipoxygenase COX

Research Areas:  

Inflammation/Immunology

FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity .
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Cat. No.: HY-P1640
CAS No.: 130154-64-2
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

(Trp63,Trp64)​-​C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca 2+ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC50 of 9.5, 2.0 and 0.8 nM, respectively .
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Cat. No.: HY-N15708
CAS No.: 755036-45-4
Synonyms: (R)-(-)-Dichotomine C
Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC50 of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC50s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions .
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Cat. No.: HY-112390
CAS No.: 227449-73-2
Target:  

5-HT Receptor Syk

Research Areas:  

Inflammation/Immunology

Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect .
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Cat. No.: HY-RS11729
Research Areas:  

Others

RBL1 Human Pre-designed siRNA Set A contains three designed siRNAs for RBL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS11730
Research Areas:  

Others

RBL2 Human Pre-designed siRNA Set A contains three designed siRNAs for RBL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS27934
Research Areas:  

Others

Rbl2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rbl2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Cat. No.: HY-N12116
CAS No.: 1967042-42-7
Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae). Maceneolignan A inhibits the release of β-hexosaminidase in RBL-2H3 cells, with an IC50 of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC50 of 63.7 μM .
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Cat. No.: HY-139247
CAS No.: 2454246-25-2
Target:  

Drug Derivative

Research Areas:  

Inflammation/Immunology

pNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC50 of 15 μM .
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Cat. No.: HY-P11128
CAS No.: 1427516-68-4
Target:  

Inhibitory Antibodies

Research Areas:  

Others

Mastoparan-V1 is a peptide belonging to the Mastoparan family. Mastoparan-V1 exhibits modest mast cell degranulation activity, with EC50 of 130.24 μM in RBL-2H3 cells. Mastoparan-V1 can be used for the study of allergic reactions induced by wasp stings .
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Cat. No.: HY-N12231
CAS No.: 75139-38-7
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 µM sup>[2]sup>[3]sup>[4].
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Cat. No.: HY-N2344R
CAS No.: 103883-03-0
Synonyms: Proanthocyanidin A1 (Standard)
Procyanidin A1 (Standard) is the analytical standard of Procyanidin A1. This product is intended for research and analytical applications. Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .
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Cat. No.: HY-P11163
CAS No.: 255720-68-4
Target:  

Bacterial Glycosidase

Research Areas:  

Infection

Eumenitin is an antibacterial peptide with strong membrane activity, broad-spectrum antibacterial activity, and almost no hemolytic toxicity. Eumenitin has inhibitory effects on various Gram positive and Gram negative bacteria. Eumenitin can induce the release of β-hexosaminidase from rat peritoneal mast cells and RBL-2H3 cells. Eumenitin can be used in the research of infectious conditions .
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Cat. No.: HY-N1186
CAS No.: 109194-60-7
Tachioside is a phenolic glycoside natural product. Tachioside inhibits antigen-induced mast cell degranulation and TNF-α expression in RBL-2H3 cells; it exhibits melanin inhibitory effects in B16 melanoma cells. Tachioside possesses anti-obesity, antioxidant, and α-glucosidase inhibitory activities. Tachioside has been predicted as a potential anti-breast cancer candidate compound and shows high correlation coefficients with antioxidant indicators such as ABTS and FRAP. Tachioside can be used in research on allergies and pigmentation-related diseases .
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Cat. No.: HY-116295
CAS No.: 7077-89-6
MRS2690 is a selective P2Y14 receptor agonist. MRS2690 inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 induces intracellular calcium mobilization, activates P38 and stimulates [ 35S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690can be used for ischemic heart disease .
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