Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
63 Results for "
SNIPERs
" in MedChemExpress (MCE) Product Catalog:
Products (63)
63 Results for "SNIPERs" in MCE Product Catalog:
Target:
Forschungsgebiete:
SNIPER (BRD)-1 is a BRD2/3/4 SNIPER degrader. SNIPER (BRD)-1 induces ubiquitin-proteasome-dependent degradation of the epigenetic regulatory proteins BRD2/3/4 as well as the IAP family E3 ligase itself with its IC50 values for cIAP1, cIAP2 and XIAP of 6.8 nM, 17 nM and 49 nM, respectively. SNIPER (BRD)-1 can be used in the research of prostate cancer .
Synonyms: E3 ligase Ligand 12
Target:
Forschungsgebiete:
cIAP1 ligand 1 is the LCL161 derivative based IAP ligand. cIAP1 ligand 1 can be connected to the ABL ligand for protein by a linker to form SNIPER. cIAP1 ligand 1 can be used in prostate cancer research .
Forschungsgebiete:
PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors (IAPs) ligands. IAPs-based degraders are also known as SNIPERs. PROTAC RAR Degrader-1 reduces RARα levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 (HY-13259). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 (HY-111843); Black: Linker (HY-140189); Blue: IAPs Ligand (HY-B0134)) .
Synonyms: BMS-354825 carbaldehyde; PROTAC ABL binding moiety 4
Forschungsgebiete:
Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
Art. -Nr.: HY-129619
CAS. Nr.: 2222354-91-6
Target:
Forschungsgebiete:
SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation .
Art. -Nr.: HY-128809
CAS. Nr.: 2357114-70-4
Synonyms: E3 ligase Ligand 11
Target:
Forschungsgebiete:
cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER.
Art. -Nr.: HY-128804
CAS. Nr.: 51951-05-4
Synonyms: PROTAC Linker 8
Target:
Forschungsgebiete:
PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker can be used in the synthesis of SNIPERs .
Art. -Nr.: HY-111848A
Reinheit: 99.26%
Target:
Forschungsgebiete:
PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs) .
Art. -Nr.: HY-111848
CAS. Nr.: 1351169-31-7
Target:
Forschungsgebiete:
PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs) .
Art. -Nr.: HY-111840
CAS. Nr.: 1225383-40-3
Forschungsgebiete:
PROTAC CRABP-II Degrader-1 is a cellular retinoic acid-binding protein (CRABP-II) SNIPER degrader. PROTAC CRABP-II Degrader-1 hijacks the cIAP1 E3 ligase to induce ubiquitination and proteasomal degradation of CRABP-II. PROTAC CRABP-II Degrader-1 can be used for the research of neuroblastoma .
Art. -Nr.: HY-122825
CAS. Nr.: 2241690-03-7
Target:
Forschungsgebiete:
SNIPER(ER)-110 consists of a IAP ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively .
Art. -Nr.: HY-111850
CAS. Nr.: 339186-54-8
Synonyms: PROTAC IAP binding moiety 1
Target:
Forschungsgebiete:
Bestatin-amido-Me, the Bestatin-based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER .
Art. -Nr.: HY-111849
CAS. Nr.: 1436868-85-7
Synonyms: CGP-57148B carbaldehyde; STI571 carbaldehyde; PROTAC ABL binding moiety 1
Forschungsgebiete:
Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
Forschungsgebiete:
HG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
