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Results for "

Taste Receptor

" in MedChemExpress (MCE) Product Catalog:

32

Inhibitors & Agonists

3

Peptides

8

Natural
Products

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W030796A
    Lactisole
    3 Publications Verification

    		 Taste Receptor Metabolic Disease
    Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets .
    Lactisole
  • HY-N0466
    Rebaudioside A

    		Glycosidase HMG-CoA Reductase (HMGCR) Fatty Acid Synthase (FASN) LDLR Others
    Rebaudioside A is an orally effective steviol glycoside with high sweetness. Rebaudioside A acts as an inhibitor of α-glucosidase with an IC50 value of 35.01 μg/mL. Rebaudioside A increases the ATP/ADP ratio in β cells in a glucose-dependent manner, thereby inhibiting KATP channels, leading to membrane depolarization, calcium influx, and ultimately stimulating insulin secretion. Rebaudioside A activates the SREBP signaling pathway by inhibiting HMGCR, the rate-limiting enzyme in cholesterol synthesis, resulting in increased expression of LDLR on the cell surface, thus promoting the uptake of LDL-C in the blood. Rebaudioside A can be used for studies on blood glucose and lipid regulation as well as anti-obesity .
    Rebaudioside A
  • HY-100047
    Nα,Nα-Bis(carboxymethyl)-L-lysine

    		Taste Receptor Others
    Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .
    Nα,Nα-Bis(carboxymethyl)-L-lysine
  • HY-136026
    Camlipixant

    BLU-5937

    		 P2X Receptor Inflammation/Immunology
    Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC50 of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough .
    Camlipixant
  • HY-N0467
    Rebaudioside C

    Dulcoside B

    		 Endogenous Metabolite Neurological Disease
    Rebaudioside C (Dulcoside B) is an orally effective natural sweetener that cannot pass the blood-brain barrier and selectively binds to human sweet taste receptors (TAS1R2/TAS1R3). The sweetness of Rebaudioside C is about 20-30 times that of sucrose, and its sweetness activity depends on the C-16/C-17 double bond structure and specific aglycones. The glycoside structure in the Rebaudioside C molecule can bind to the sweet taste receptor, activate the taste signal transduction pathway, and produce sweetness perception .
    Rebaudioside C
  • HY-D0887
    Disodium 5'-inosinate
    1 Publications Verification

    IMP disodium salt; Disodium inosinate

    		 Others Metabolic Disease
    Disodium 5'-inosinate (IMP disodium salt) is a nucleotide-based umami agent. Disodium 5'-inosinate can bind to umami receptors and stimulate taste nerves, allowing the brain to perceive umami. In addition, Disodium 5'-inosinate produces a transient behavioral excitement in mice .
    Disodium 5'-inosinate
  • HY-B1146
    Denatonium benzoate
    1 Publications Verification

    THS-839

    		 Environmental Pollutants Insecticide Inflammation/Immunology Endocrinology
    Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility .
    Denatonium benzoate
  • HY-111664
    (R)-(+)-Citronellal

    (+)-Citronellal

    		 Bacterial Fungal Insecticide Taste Receptor Opioid Receptor Infection Neurological Disease Inflammation/Immunology
    (R)-(+)-Citronellal ((+)-Citronellal) is a monoterpenoid compound and is one of the main components of essential oils from plants such as lemon grass. (R)-(+)-Citronellal has antibacterial, antifungal, and insecticidal activities. (R)-(+)-Citronellal alleviates the bitterness of caffeine by antagonizing the bitter taste receptors Tas2r43 (IC50 = 84 μM) and Tas2R46. (R)-(+)-Citronellal generates analgesic activity by activating the opioid receptor (broad-spectrum opioid receptor) pathway, and its effect is particularly significant for inflammatory pain .
    (R)-(+)-Citronellal
  • HY-N2084
    Perillartine
    2 Publications Verification

    DL-Perillartine

    		 Endogenous Metabolite Others
    Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.
    Perillartine
  • HY-P4648
    H-Trp-Trp-Trp-OH

    Trp-Trp-Trp

    		 Bacterial Infection
    H-Trp-Trp-Trp-OH (Trp-Trp-Trp) is a tripeptide consisting of tryptophan. H-Trp-Trp-Trp-OH has antibacterial activity. H-Trp-Trp-Trp-OH is a human bitter taste receptor hTAS2R14 agonist .
    H-Trp-Trp-Trp-OH
  • HY-136429A
    Ethylhydrocupreine hydrochloride

    Optochin hydrochloride

    		 Bacterial Parasite Infection
    Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .
    Ethylhydrocupreine hydrochloride
  • HY-153265
    TAS2R14 agonist-2

    		Taste Receptor Inflammation/Immunology
    TAS2R14 agonist-2 (compound 28.1) is a potent and selective TAS2R14 agonist with an EC50 value of 72 nM. TAS2R14 agonist-2 reveals marked selectivity over a panel of 24 non-bitter taste human G protein-coupled receptors. TAS2R14 agonist-2 can be used for the studies of asthma or chronic obstructive pulmonary disease .
    TAS2R14 agonist-2
  • HY-139091
    FEMA 4774

    		Taste Receptor Others
    FEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer .
    FEMA 4774
  • HY-W030796
    Lactisole free acid
    3 Publications Verification

    		 Taste Receptor Metabolic Disease
    Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets .
    Lactisole free acid
  • HY-110206
    AM6545

    		Cannabinoid Receptor Metabolic Disease
    AM6545 is a highly selective, brain-free (peripherally active) CB1 receptor antagonist (Ki=1.7 nM). AM6545 inhibits endocannabinoid signaling by competitively antagonizing CB1 receptors, inhibiting CB1-mediated appetite stimulation and inflammatory responses without affecting cAMP levels. AM6545 significantly reduces food intake and body weight in mice, while improving metabolic syndrome-related renal impairment (such as proteinuria, fibrosis) and insulin resistance. AM6545 can be used in the study of obesity and its complications .
    AM6545
  • HY-106432A
    Sabcomeline hydrochloride

    SB-202026 hydrochloride; Memric hydrochloride

    		 mAChR Dopamine Receptor Neurological Disease
    Sabcomeline (SB-202026; Memric) hydrochloride is a muscarinic receptor agonist capable of crossing the blood-brain barrier. Sabcomeline hydrochloride exhibits affinity for all hM1 to hM5 subtypes (pKi=6.72-7.23), and shows near-full agonism at the hM3 receptor, inducing extracellular acidification. Sabcomeline hydrochloride alters the binding kinetics of dopamine D2 receptors through neural network regulation. Sabcomeline hydrochloride also causes minimal cardiovascular changes, effectively reverses spatial memory deficits in rodents and induces conditioned taste aversion. Sabcomeline hydrochloride is an important tool compound in studies of Alzheimer's disease and related neurodegenerative diseases .
    Sabcomeline hydrochloride
  • HY-B1390A
    Saccharin sodium

    		Environmental Pollutants Bacterial Infection
    Saccharin sodium is an orally active, non-caloric artificial sweetener (NAS). Saccharin sodium has bacteriostatic and microbiome-modulating properties. Saccharin binds to and signals via specific taste receptors, not only in the oral cavity but also alongside the gastrointestinal tract. Saccharin has been reported to bind the human and rodent heteromeric guanine nucleotide-binding protein (G protein) coupled sweet taste receptors T1R2/T2R3 as well as the human bitter taste receptor T2R43 and T2R44. Saccharin can inhibit bacterial growth in vitro .
    Saccharin sodium
  • HY-N0742
    Absinthin

    		Others Others
    Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca 2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .
    Absinthin
  • HY-139898
    S7958

    		Taste Receptor Others
    S7958 is a selective and orally active antagonist of the TAS2R8 bitter taste receptor, with its IC50 being 0.06 μM. S7958 only has a weak inhibitory effect on TASR8 and TAS2R39, and has no significant impact on other receptors. S7958 significantly inhibits the perception of bitterness caused by substances such as coffee and drug active ingredients (API) by selectively antagonizing the human bitter taste receptor TAS2R8. S7958 can be used in the medical field to improve the research on the bitterness of oral preparations .
    S7958
  • HY-124956
    GIV3727

    		Taste Receptor Others
    GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine .
    GIV3727
  • HY-136429
    Ethylhydrocupreine

    Optochin

    		 Bacterial Parasite Infection
    Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .
    Ethylhydrocupreine
  • HY-153264
    TAS2R14 agonist-1

    		Taste Receptor Others
    TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC50 of 116.6 ±23.6 nM .
    TAS2R14 agonist-1
  • HY-B1390AR
    Saccharin sodium (Standard)

    		Bacterial Reference Standards Infection
    Saccharin (sodium) (Standard) is the analytical standard of Saccharin (sodium). This product is intended for research and analytical applications. Saccharin sodium is an orally active, non-caloric artificial sweetener (NAS). Saccharin sodium has bacteriostatic and microbiome-modulating properties. Saccharin binds to and signals via specific taste receptors, not only in the oral cavity but also alongside the gastrointestinal tract. Saccharin has been reported to bind the human and rodent heteromeric guanine nucleotide-binding protein (G protein) coupled sweet taste receptors T1R2/T2R3 as well as the human bitter taste receptor T2R43 and T2R44. Saccharin can inhibit bacterial growth in vitro .
    Saccharin sodium (Standard)
  • HY-W724355
    Denatonium benzoate-d5

    THS-839-d5

    		 Isotope-Labeled Compounds Taste Receptor Metabolic Disease Inflammation/Immunology
    Denatonium benzoate-d5 (THS-839-d5) is the deuterium labeled Denatonium benzoate (HY-B1146). Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility .
    Denatonium benzoate-d5
  • HY-19158
    Org 13011

    		5-HT Receptor Neurological Disease
    Org 13011 is a central nervous system-active 5-HT1A receptor agonist that induces conditioned taste aversion.
    Org 13011
  • HY-19158A
    Org-13011 fumarate

    		5-HT Receptor Neurological Disease
    Org 13011 fumarate is a central nervous system-active 5-HT1A receptor agonist that induces conditioned taste aversion .
    Org-13011 fumarate
  • HY-136352
    Adenosine 5'-succinate

    		Taste Receptor Others
    Adenosine 5'-succinate is a chemically AMP-related compound and potently inhibits Denatonium benzoate/taste receptor activation of transducin .
    Adenosine 5'-succinate
  • HY-N2084R
    Perillartine (Standard)

    DL-Perillartine (Standard)

    		 Reference Standards Endogenous Metabolite Others
    Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.
    Perillartine (Standard)
  • HY-117868
    NC-174

    CP-Dpm-GA

    		 Fluorescent Dye Others
    NC-174 is a super-strong guanidine compound that is sweeter than sucrose. NC-174 is more than 300,000 times sweeter than sucrose and has the potential to be a probe for sweet taste receptors .
    NC-174
  • HY-136429AR
    Ethylhydrocupreine hydrochloride (Standard)

    Optochin hydrochloride (Standard)

    		 Reference Standards Bacterial Parasite Infection
    Ethylhydrocupreine (hydrochloride) (Standard) is the analytical standard of Ethylhydrocupreine (hydrochloride). This product is intended for research and analytical applications. Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .
    Ethylhydrocupreine hydrochloride (Standard)
  • HY-100047R
    Nα,Nα-Bis(carboxymethyl)-L-lysine (Standard)

    		Taste Receptor Reference Standards Others
    Nα,Nα-Bis(carboxymethyl)-L-lysine (Standard) is the analytical standard of Nα,Nα-Bis(carboxymethyl)-L-lysine (HY-100047). This product is intended for research and analytical applications. Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .
    Nα,Nα-Bis(carboxymethyl)-L-lysine (Standard)
  • HY-N0742R
    Absinthin (Standard)

    		Reference Standards Others Others
    Absinthin (Standard) is the analytical standard of Absinthin. This product is intended for research and analytical applications. Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .
    Absinthin (Standard)

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