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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
complement-dependent cytotoxicity
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "complement-dependent cytotoxicity" in MCE Product Catalog:
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1 Cited Publications
Cat. No.: HY-P9976
CAS No.: 1461640-62-9
Synonyms: ch38SB19; hu38SB19; SAR-650984
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1 Cited Publications
Cat. No.: HY-P9976A
CAS No.: 1461640-62-9
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Cat. No.: HY-P9948
CAS No.: 216503-57-0
Synonyms: Campath-IH
Cat. No.: HY-P9933
CAS No.: 1363687-32-4
Synonyms: APN-311; Ch14.18; MAb-14.18
Cat. No.: HY-P9961
CAS No.: 679818-59-8
Synonyms: GSK1841157; OMB-157
Cat. No.: HY-P991564
CAS No.: 3031170-61-0
Synonyms: IBI-343 antibody; HB37A6; TAK-921 Antibody
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Cat. No.: HY-P99674
CAS No.: 2364496-42-2
Synonyms: GEN-3009
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Cat. No.: HY-177578
Research Areas:
NN3201 is a c-Kit-targeting antibody-drug conjugate (ADC) with high affinity (KD = 0.19 pM). NN3201 is composed of 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid-glu(PEG24-Me)-val-cit-NH-benzyloxyformic acid-MMAE (HY-178219) and an anti-c-Kit human monoclonal antibody NN2101 (HY-P991293). NN3201 rapidly internalizes and inhibits stem cell factor (SCF)-driven signaling, thereby delivering its payload to induce cell cycle arrest and apoptosis. NN3201 exhibits no Fc-mediated effector functions antibody-dependent cell-mediated cytotoxicity (ADCC)/complement-dependent cytotoxicity (CDC) due to reduced FcγR binding. NN3201 exhibits significant c-Kit-dependent anti-tumor efficacies in various tumor models. NN3201 can be used in small cell lung cancer (SCLC) and gastrointestinal stromal tumor (GIST) and acute myeloid leukemia (AML) research [1][2].
Cat. No.: HY-P990902
CAS No.: 2733581-82-1
Synonyms: BMS-986012
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Cat. No.: HY-P991229
Synonyms: AGS-1C4D4; AGS-PSCA
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Cat. No.: HY-P99952
CAS No.: 2249927-04-4
Synonyms: SCT400
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Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Cat. No.: HY-P9968A
CAS No.: 780758-10-3
Cat. No.: HY-P991547
CAS No.: 922534-56-3
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Cat. No.: HY-P990076
CAS No.: 2131168-99-3
Synonyms: APN-301; hu14.18-IL2; EMD 273063
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Cat. No.: HY-P991507
Synonyms: Demupitamab
Cat. No.: HY-P991458
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Cat. No.: HY-P992445
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
