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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
deacetylation
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "deacetylation" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-19759
CAS No.: 1001908-89-9
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM . SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels .
4
4 Cited Publications
Cat. No.: HY-P2161B
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2
1
1 Cited Publications
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BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP .
1
1 Cited Publications
Cat. No.: HY-W083373A
CAS No.: 5416-71-7
3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research .
1
Synonyms: Hegzadesil; Trimethylamine hydrochloric acid; Trimethylamine monohydrochloride
Cat. No.: HY-P11212
CAS No.: 1193634-36-4
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Cat. No.: HY-Y0504S3
CAS No.: 18856-86-5
Cat. No.: HY-N2126
CAS No.: 952068-57-4
Category:
Orchidaceae Extract Gastrodia elata Bl. Other Diseases Phenols Plants Disease Research Fields
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Cat. No.: HY-W585865
CAS No.: 112710-84-6
Synonyms: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine Tris
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Cat. No.: HY-P5544
CAS No.: 60230-21-9
Synonyms: N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid
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Cat. No.: HY-16138
CAS No.: 936221-33-9
Synonyms: CG-200745
Ivaltinostat (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat inhibits deacetylation of histone H3 and tubulin. Ivaltinostat induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat induces apoptosis and has anti-tumour effects .
Cat. No.: HY-16138A
CAS No.: 3078712-42-9
Synonyms: CG-200745 formic
Research Areas:
Ivaltinostat (CG-200745) formic is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat formic enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat formic induces apoptosis and has anti-tumour effects .
Synonyms: Hegzadesil (Standard); Trimethylamine hydrochloric acid (Standard); Trimethylamine monohydrochloride (Standard)
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Cat. No.: HY-P11213
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Cat. No.: HY-Y0504S1
CAS No.: 107766-37-0
Synonyms: Hegzadesil-d10; Trimethylamine hydrochloric acid-d10; Trimethylamine monohydrochloride-d10
Cat. No.: HY-Y0504S
CAS No.: 2483824-12-8
Cat. No.: HY-P2161
CAS No.: 872719-49-8
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Cat. No.: HY-155727
CAS No.: 670267-73-9
Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
