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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1998 Results for "
disulfide bond rearrangement
" in MedChemExpress (MCE) Product Catalog:
Products (1998)
1998 Results for "disulfide bond rearrangement" in MCE Product Catalog:
162
162 Publications Verification
Synonyms: Tetraethylthiuram disulfide; TETD
Research Areas:
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu 2+ increases intracellular ROS levels and induces cuproptosis .
136
136 Cited Publications
Cat. No.: HY-P1410
CAS No.: 1209500-46-8
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
136
136 Cited Publications
Cat. No.: HY-P1410A
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
60
60 Cited Publications
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Research Areas:
BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .
49
49 Cited Publications
Synonyms: DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol
37
Target:
30
30
30 Cited Publications
Synonyms: α-Hypophamine acetate; Oxytocic hormone acetate
25
25 Cited Publications
Cat. No.: HY-P0028
CAS No.: 17466-45-4
Target:
Research Areas:
22
17
Target:
Research Areas:
Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) .
17
Category:
Infection Natural Products Plants Liliaceae Extract Disease Research Fields A．Sativam L. var．Viviparum Regel
Target:
17
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
17
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
15
15 Cited Publications
Cat. No.: HY-16993
CAS No.: 1801787-56-3
OICR-9429, a chemical probe, is high affinity WD repeat domain 5 (WDR5) inhibitor, competitively blocks WDR5 interaction with MLL protein via binding the central peptide-binding pocket of WDR5. OICR-9429 can suppress histone H3K4 trimethylation and can be used for the research of various cancers including non-MLL-rearranged leukaemia, colon, pancreatic, prostate cancer and bladder cancer (BCa) .
13
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Research Areas:
13
13 Cited Publications
Synonyms: Hypocretin-1 (human, rat, mouse)
Target:
Research Areas:
13
13 Cited Publications
Cat. No.: HY-106224B
Purity: 99.93%
Synonyms: Hypocretin-1 (human, rat, mouse) acetate
Target:
Research Areas:
13
Target:
Research Areas:
13
13 Cited Publications
Cat. No.: HY-106224A
Purity: 97.13%
Synonyms: Hypocretin-1 (human, rat, mouse) TFA
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
