7 Results for "

fibrillization

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "fibrillization" in MCE Product Catalog:

Cat. No.: HY-34596
CAS No.: 2380-94-1
4-Hydroxyindole is a type of hydroxyindole in which the 1H-indole at position 4 is substituted by a hydroxyl group. 4-Hydroxyindole serves as an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. 4-Hydroxyindole inhibits amyloid fibrillization and induces liver function impairment, thyroid abnormalities, and blood glucose fluctuations in mice. 4-Hydroxyindole holds potential for research in neurodegenerative diseases and metabolic disorders .
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Cat. No.: HY-P3846
CAS No.: 1802086-22-1
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease .
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Cat. No.: HY-139740
CAS No.: 2847131-53-5
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Fibrillization modulator 1 stabilizes monomers.
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Cat. No.: HY-156179
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

DDC 2′,3′-O-disulfate (compound 4) prevents the fibrillization and oligomerization of Aβ42. DDC 2′,3′-O-disulfate has the potential for Alzheimer's disease (AD) research .
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Cat. No.: HY-156180
Target:  

Drug Metabolite

Research Areas:  

Neurological Disease

DDC 3′-O-β-D glucuronide (compound 5) is a drug metabolite that can prevent the fibrillization and oligomerization of Aβ42. DDC 3′-O-β-D glucuronide has potential for the research of Alzheimer's disease .
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Cat. No.: HY-N12321
CAS No.: 54299-64-8
2',3'-Dihydroxy-4',6'-dimethoxychalcone (compound 1) can inhibit Amyloid β-protein (Aβ42) fibrillization and aggregation. 2',3'-Dihydroxy-4',6'-dimethoxychalcone has oral activity and can be detected in the brain .
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Cat. No.: HY-119416
CAS No.: 21763-71-3
Sequoiaflavone is a biflavonoid compound with multiple activities. Sequoiaflavone suppresses hepatic CYP1A1/(7-Ethoxycoumarin O-deethylase) ECOD, prevents 1-42 fibrillization (IC50 = 0.29 μM) and disaggregates amyloid fibrils (EC50 = 2.04 μM), inhibits Alternaria alternata and inhibits human recombinant PDE5A1 overexpressed in COS-7 cells (IC50 = 19.9 μM) to exert NO-independent vasodilation. Sequoiaflavone can be used in Alzheimer's disease, peripheral circulatory disorder, and antifungal research .
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