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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
free cysteine
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "free cysteine" in MCE Product Catalog:
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N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .
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28 Cited Publications
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MitoTracker Deep Red (MTDR) FM fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Deep Red FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 644/665 nm . MitoTracker Deep Red dyes have an excitation/emission wavelength of 633/650-750 nm .
The Ex/Em of MitoTracker Deep Red (MTDR) FM is 644/665 nm.
The Ex/Em of MitoTracker Deep Red (MTDR) FM is 644/665 nm.
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2 Cited Publications
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Biotin-BMCC is a Maliemide (HY-W007324) conjugated biotin molecule that has a high affinity for free thiol groups of cysteines .
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Cat. No.: HY-W020780
CAS No.: 724722-89-8
Synonyms: mPEG5000-Maleimide
Cat. No.: HY-171135
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Cetuximab MMAE is an antibody-drug conjugate (ADC) targeting EGFR, formed by the random conjugation of the Cetuximab (HY-P9905) antibody and VcMMAE (HY-15575) via reduced interchain cysteines. Cetuximab MMAE binds to EGFR, blocks ligand interactions, inhibits downstream signal transduction, mediates receptor internalization, and delivers MMAE to induce G2/M phase cell cycle arrest, inhibit microtubule polymerization, interfere with mitosis, and exert radiosensitizing effects. Cetuximab MMAE limits the toxicity of free MMAE to EGFR-expressing cells and circumvents EGFR resistance mechanisms. Cetuximab MMAE is applicable to research related to EGFR + tumors .
Cat. No.: HY-D0843S
CAS No.: 360768-37-2
Synonyms: NEM-d5
Cat. No.: HY-DY1032
CAS No.: 201860-17-5
Solvent and concentration: DMSO: 1 mM
Cat. No.: HY-E70364
CAS No.: 1892548-76-3
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IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .
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MTSEA hydrobromide is a sulfhydryl-reactive compound that modifies free cysteine residues to produce a positively charged side chain approximately the size of lysine .
Cat. No.: HY-W738256
CAS No.: 180152-82-3
Synonyms: MDTPA
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Maleimide-DTPA (MDTPA) is a maleimide-functionalized bifunctional chelator that enables site-specific conjugation via a thioether bond to single-domain antibody fragments (sdAb) containing free cysteine, and mediates 111In radiolabeling. DTPA-2Rs15d-HLC, formed by the conjugation of Maleimide-DTPA with anti-HER2 sdAb 2Rs15d-HLC, retains high affinity for HER2 with a Kd of 5.9 nM, and maintains targeting ability to HER2-positive cells and tumors after 111In labeling. Maleimide-DTPA can be used for radiotracer construction, SPECT molecular imaging, and HER2-positive tumor research .
Cat. No.: HY-D2902
CAS No.: 2080332-70-1
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Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
SNOTRAP (SNO trapping by triaryl phosphine) is a chemical probe used for detecting S-nitrosylated (SNO) proteins. SNOTRAP selectively converts S-nitrosylated cysteines in proteins into stable disulfide-iminophosphorane intermediates, which are then enriched with streptavidin and detected by nanoLC-MS/MS. SNOTRAP enables global enrichment and label-free quantification of SNO proteins and their modification sites in complex biological samples such as mouse brain tissues. SNOTRAP can be applied to studies related to nitrosative stress-associated diseases, including neurodegenerative diseases, cancer, and multiple sclerosis .
Cat. No.: HY-D0078
CAS No.: 76877-34-4
Cat. No.: HY-17525
CAS No.: 163269-30-5
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Bethoxazin is a yeast DNA topoisomerase II inhibitor with an IC50 of 5.3 μM, and also a broad-spectrum industrial microbicide and covalent adduct-forming agent. Bethoxazin inhibits the catalytic activity of yeast DNA topoisomerase II by reacting with the key free cysteine thiol group on the enzyme. Bethoxazin forms covalent adducts with molecules containing free thiol groups. Bethoxazin inhibits the growth of yeast cells. Bethoxazin can be used in studies related to the growth of fungi, molds and algae .
Cat. No.: HY-152919
CAS No.: 2387738-43-2
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Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. Maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery with the help of the PAB structure.
Cat. No.: HY-P10540
CAS No.: 2383115-01-1
Cat. No.: HY-180497
CAS No.: 83016-63-1
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DBNBS is a radical scavenger. DBNBS undergoes non-radical nucleophilic addition to bind directly to cysteine (e.g., Cys-34 of BSA) to form a hydroxylamine, which is subsequently oxidized to produce an artifact spin adduct signal. DBNBS can be used for detecting biological free radicals .
Cat. No.: HY-DY1105
CAS No.: 873315-86-7
Synonyms: MTDR FM (solution)
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MitoTracker Deep Red FM (solution) (MTDR FM (solution)) selectively accumulates in the mitochondrial matrix. MitoTracker Deep Red FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. The Ex/Em of MitoTracker Deep Red (MTDR) FM is 644/665 nm.
Solvent and concentration: DMSO: 1 mM
Solvent and concentration: DMSO: 1 mM
Cat. No.: HY-D3436
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Pt-Luc is a bioluminescent probe used for real-time, non-invasive monitoring of Pt (IV) prodrug reduction in living cells and animal models. The detection mechanism of Pt-Luc relies on the intracellular reduction mediated by active cysteine residues in proteins. Pt-Luc can penetrate the membrane of living cells; after entering cells, active cysteine thiolates in high-molecular-weight protein components reduce the Pt (IV) complex, thereby cleaving the caged aminoluciferin substrate. The released free aminoluciferin is then oxidized by luciferase in the presence of ATP to generate a bioluminescent signal, whose intensity is directly correlated with the reduction degree of Pt (IV) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
