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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
700 Results for "
hepatically
" in MedChemExpress (MCE) Product Catalog:
Products (700)
700 Results for "hepatically" in MCE Product Catalog:
185
185
185 Publications Verification
Referencia número: HY-B0011A
No. CAS: 148408-66-6
Synonyms: RP-56976 Trihydrate
Áreas de investigación:
Docetaxel Trihydrate (RP-56976 Trihydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel Trihydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel Trihydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel Trihydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel Trihydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel Trihydrate can be used in cancer-related research .
82
82 Cited Publications
Synonyms: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide
54
54 Cited Publications
Synonyms: Foxgreen; IC Green; Cardiogreen
54
54 Cited Publications
Áreas de investigación:
54
54 Cited Publications
Áreas de investigación:
54
54 Cited Publications
Referencia número: HY-114118A
Pureza: 99.92%
Áreas de investigación:
43
43 Cited Publications
Áreas de investigación:
SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5 .
36
36 Cited Publications
Synonyms: Sodium taurocholate; N-Choloyltaurine sodium
Target:
36
36 Cited Publications
Referencia número: HY-B1131
No. CAS: 345909-26-4
Synonyms: Sodium taurocholate hydrate; N-Choloyltaurine sodium salt hydrate
Target:
36
Category:
Human Gut Microbiota Metabolites Endogenous metabolite Disease Research Fields Inflammation/Immunology Steroids
Target:
36
36 Cited Publications
Synonyms: GSK3326595; EPZ015938
Pemrametostat (GSK3326595) is a protein arginine methyltransferase 5 (PRMT5) inhibitor. Pemrametostat decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. Pemrametostat can be used for research of relapsed/refractory mantle cell lymphoma .
35
35 Cited Publications
Synonyms: Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium
35
35 Cited Publications
Synonyms: Ursodeoxycholate; Ursodiol; UDCA
18
18 Cited Publications
Referencia número: HY-P0299
No. CAS: 283609-79-0
Target:
Áreas de investigación:
18
18 Cited Publications
Referencia número: HY-P0299A
No. CAS: 2828433-17-4
Target:
Áreas de investigación:
13
10
10 Cited Publications
Referencia número: HY-104081
No. CAS: 11041-12-6
Synonyms: Cholestyramine resin; Colestyramine
Áreas de investigación:
Cholestyramine (Cholestyramine resin) is an orally active bile acid sequestrant. Cholestyramine upregulates the expression of intestinal Apical sodium-dependent bile acid transporter and hepatic Cholesterol 7α-hydroxylase. Cholestyramine induces the expression of intestinal and hepatic cholesterol synthesis genes as well as hepatic lipogenesis genes, and promotes bile acid- and neutral sterol-mediated reverse cholesterol transport. Cholestyramine reduces intestinal cholesterol absorption and induces cholesterol efflux. Cholestyramine is applicable to research related to coronary artery disease, atherosclerotic cardiovascular disease and atherosclerosis .
9
9 Cited Publications
Áreas de investigación:
E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .
9
9 Cited Publications
Áreas de investigación:
E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
