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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
melanocortin-4 receptor
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "melanocortin-4 receptor" in MCE Product Catalog:
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1 Cited Publications
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THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .
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PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC50 of 13 nM (Ki=0.46 nM). PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa .
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1 Cited Publications
Cat. No.: HY-P1216A
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Cat. No.: HY-W002603
CAS No.: 31166-44-6
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PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 ± 1 nM . Pf-446687 is brain penetrant .
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MK-0493 is an orally active melanocortin-4 receptor (MC4R) agonist. MK-0493 reduces food intake, suppresses weight gain, elevates blood pressure at high doses, and exhibits preclinical erectile regulatory activity. MK-0493 can be used in research related to obesity .
Cat. No.: HY-P0060
CAS No.: 16960-16-0
Synonyms: Tetracosactrin; ACTH(1–24)
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Cat. No.: HY-P0060A
CAS No.: 60189-34-6
Synonyms: Tetracosactrin acetate; ACTH(1–24) acetate
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Cat. No.: HY-P10927A
Synonyms: BRINP2-related peptide TFA
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SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor .
Cat. No.: HY-P3561A
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Cat. No.: HY-P10927
Synonyms: BRINP2-related peptide
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Cat. No.: HY-P2242A
CAS No.: 1373926-49-8
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Cat. No.: HY-P1504
CAS No.: 17908-57-5
Synonyms: Beta-MSH (1-22) (human)
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Cat. No.: HY-P1504A
Synonyms: Beta-MSH (1-22) (human) TFA
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Cat. No.: HY-P1208
CAS No.: 667430-81-1
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Cat. No.: HY-P4764
CAS No.: 819048-44-7
Synonyms: Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2
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LY2112688 (Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2) is a synthetic peptide selective melanocortin 4 receptor (MC4R) agonist with a Ki of 0.13 nM for human MC4R and Ki values of 165, 74, and 1713 nM for human MC1R, MC3R, and MC5R, respectively. LY2112688 activates MC4R-mediated cAMP signaling and promotes PYY and GLP-1 release by activating peripheral MC4R in enteroendocrine L cells; Kir7.1 signaling in MC4R neurons is involved in its sustained suppression of food intake. LY2112688 inhibits food intake in vivo and can elevate heart rate and blood pressure. LY2112688 is useful for research on obesity, energy homeostasis, and MC4R signaling .
Cat. No.: HY-U00396
CAS No.: 455957-28-5
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MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R), used in the research of obesity, diabetes, and sexual dysfunction.
Cat. No.: HY-P3561
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
