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Results for "

melanocortin-4 receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Melanocortin Receptor (28) AMPK (1) AP-1 (2) Biochemical Assay Reagents (1) Calmodulin (1) CRFR (2) Drug Intermediate (1) PKA (2) Reference Standards (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (10) Inflammation/Immunology (8) Metabolic Disease (17) Neurological Disease (14)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Antibodies

Targets Recommended: Melanocortin Receptor

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-19870

Setmelanotide Maximum Cited Publications 8 Publications Verification RM-493; BIM-22493; IRC-022493	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively .

HY-10624

THIQ 1 Publications Verification	Melanocortin Receptor	Metabolic Disease
THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC₅₀=1.2 nM, EC₅₀=2.1 nM) and rMC4R (IC₅₀=0.6 nM, EC₅₀=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .

HY-148349

PF-07258669 1 Publications Verification	Melanocortin Receptor	Neurological Disease Metabolic Disease
PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC₅₀ of 13 nM (K_i=0.46 nM). PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa .

HY-W002603

Benzyl piperazine-1-carboxylate	Biochemical Assay Reagents Drug Intermediate	Neurological Disease
Benzyl piperazine-1-carboxylate is a synthetic intermediate that can be used in the research of melanocortin-4 (MC4) receptor antagonists .

HY-10622

PF-00446687 free base	Melanocortin Receptor	Endocrinology
PF-00446687 is a potent, selective **melanocortin-4 receptor (MC4R) agonist with EC50** of 12 ± 1 nM . Pf-446687 is brain penetrant .

HY-118930

MK-0493	Melanocortin Receptor	Metabolic Disease
MK-0493 is an orally active melanocortin-4 receptor (MC4R) agonist. MK-0493 reduces food intake, suppresses weight gain, elevates blood pressure at high doses, and exhibits preclinical erectile regulatory activity. MK-0493 can be used in research related to obesity .

HY-P0060

Tetracosactide Tetracosactrin; ACTH(1–24)	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P0060A

Tetracosactide acetate Tetracosactrin acetate; ACTH(1–24) acetate	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P3561A

Agouti-related Protein (AGRP) (83-132) Amide (human) TFA	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the **melanocortin-4 receptor** (MC4R) to increase food intake .

HY-P10927A

BRP TFA BRINP2-related peptide TFA	PKA AP-1	Metabolic Disease
BRP (BRINP2-related peptide) TFA is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP TFA induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP TFA exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP TFA is independent of the leptin, GLP-1 receptor and **melanocortin 4 receptor** pathways. BRP TFA is applicable to obesity-related research .

HY-11030A

SNT-207858 free base	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active *melanocortin-4* (MC-4) *receptor* antagonist. SNT207858 free base has an IC₅₀ of 22 nM (binding) and 11 nM (function) on the MC-4 receptor .

HY-P10927

BRP BRINP2-related peptide	AP-1 PKA	Metabolic Disease
BRP is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP is independent of the leptin, GLP-1 receptor and **melanocortin 4 receptor** pathways. BRP is applicable to obesity-related research .

HY-19870C

Setmelanotide monoacetate Maximum Cited Publications 8 Publications Verification RM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate	Melanocortin Receptor Calmodulin AMPK	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Setmelanotide monoacetate (RM-493 monoacetate) is a blood-brain barrier-permeable, selective MC4R agonist with a K_i value of 2.1 nM for hMC4R. Setmelanotide monoacetate activates the CaMKK2/AMPK signaling pathway. Setmelanotide monoacetate mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide monoacetate is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression .

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects .

HY-P1504

β-Melanocyte Stimulating Hormone (MSH), human Beta-MSH (1-22) (human)	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous **melanocortin-4 receptor (MC4-R**) agonist .

HY-P1504A

β-Melanocyte Stimulating Hormone (MSH), human TFA Beta-MSH (1-22) (human) TFA	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous **melanocortin-4 receptor (MC4-R**) agonist .

HY-P1478

Adrenocorticotropic Hormone (ACTH) (4-10), human	Melanocortin Receptor	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent **melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀**=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P3561

Agouti-related Protein (AGRP) (83-132) Amide (human)	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the **melanocortin-4 receptor** (MC4R) to increase food intake .

HY-U00396

MC-4R Agonist 1	Melanocortin Receptor	Metabolic Disease Endocrinology
MC-4R Agonist 1 is an agonist of *human melanocortin-4* receptor (MC-4R)**, used in the research of obesity, diabetes, and sexual dysfunction.

HY-P1216

HS014	Melanocortin Receptor	Neurological Disease
HS014 is a potent and selective **melanocortin-4 (MC4) receptor antagonist, with K_i*s of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors*, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats .

HY-P2242

RO27-3225	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 shows 30-fold selectivity for MC4R over MC3R. RO27-3225 has neuroprotective and anti-inflammatory effects .

HY-P1216A

HS014 TFA 1 Publications Verification	Melanocortin Receptor	Neurological Disease
HS014 TFA is a potent and selective **melanocortin-4 (MC4) receptor antagonist, with K_i*s of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors* respectively. HS014 TFA increases food intake in free-feeding rats .

HY-10623

PF-00446687 hydrochloride	Melanocortin Receptor	Endocrinology
PF-00446687 hydrochloride is a potent, brain-penetrating, selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 12 nM. PF-00446687 hydrochloride can be used in the research of sexual dysfunction .

HY-19870A

Setmelanotide TFA RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively .

HY-148349A

(2R,2R)-PF-07258669	Melanocortin Receptor	Neurological Disease Metabolic Disease
(2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist. (2R,2R)-PF-07258669 can be used in the study of regulating appetite and energy expenditure .

HY-11030

SNT-207858	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active *melanocortin-4* (MC-4) *receptor* antagonist. SNT207858 has an IC₅₀ of 22 nM (binding) and 11 nM (function) on the MC-4 receptor .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent **melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀**=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-10622R

PF-00446687 free base (Standard)	Reference Standards Melanocortin Receptor	Endocrinology
PF-00446687 free base (Standard) is the analytical standard of PF-00446687 free base (HY-10622). This product is intended for research and analytical applications. PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC₅₀ of 12 ± 1 nM . Pf-446687 is brain penetrant .

HY-10624R

THIQ (Standard)	Reference Standards Melanocortin Receptor	Metabolic Disease
THIQ (Standard) is the analytical standard of THIQ (HY-10624). This product is intended for research and analytical applications. THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC₅₀=1.2 nM, EC₅₀=2.1 nM) and rMC4R (IC₅₀=0.6 nM, EC₅₀=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .

HY-183106

MC4R antagonist-2	Melanocortin Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
MC4R antagonist-2 is a potent **melanocortin 4 receptor (MC4R) antagonist with an IC₅₀** of 0.54 nM. MC4R antagonist-2 can be used for the research of MC4R-mediated conditions, such as cachexia, osteoporosis, neuropathic pain, depression, hypertension, malnutrition-related obesity, and associated inflammatory diseases .

Cat. No.	상품명	Type

HY-W002603

Benzyl piperazine-1-carboxylate	Biochemical Assay Reagents
Benzyl piperazine-1-carboxylate is a synthetic intermediate that can be used in the research of melanocortin-4 (MC4) receptor antagonists .

Cat. No.	상품명	Target	Research Area

HY-19870

Setmelanotide Maximum Cited Publications 8 Publications Verification RM-493; BIM-22493; IRC-022493	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively .

HY-P0060

Tetracosactide Tetracosactrin; ACTH(1–24)	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P0060A

Tetracosactide acetate Tetracosactrin acetate; ACTH(1–24) acetate	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P3561A

Agouti-related Protein (AGRP) (83-132) Amide (human) TFA	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the **melanocortin-4 receptor** (MC4R) to increase food intake .

HY-P10927A

BRP TFA BRINP2-related peptide TFA	PKA AP-1	Metabolic Disease
BRP (BRINP2-related peptide) TFA is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP TFA induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP TFA exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP TFA is independent of the leptin, GLP-1 receptor and **melanocortin 4 receptor** pathways. BRP TFA is applicable to obesity-related research .

HY-P10927

BRP BRINP2-related peptide	AP-1 PKA	Metabolic Disease
BRP is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP is independent of the leptin, GLP-1 receptor and **melanocortin 4 receptor** pathways. BRP is applicable to obesity-related research .

HY-19870C

Setmelanotide monoacetate Maximum Cited Publications 8 Publications Verification RM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate	Melanocortin Receptor Calmodulin AMPK	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Setmelanotide monoacetate (RM-493 monoacetate) is a blood-brain barrier-permeable, selective MC4R agonist with a K_i value of 2.1 nM for hMC4R. Setmelanotide monoacetate activates the CaMKK2/AMPK signaling pathway. Setmelanotide monoacetate mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide monoacetate is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression .

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects .

HY-P1504

β-Melanocyte Stimulating Hormone (MSH), human Beta-MSH (1-22) (human)	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous **melanocortin-4 receptor (MC4-R**) agonist .

HY-P1504A

β-Melanocyte Stimulating Hormone (MSH), human TFA Beta-MSH (1-22) (human) TFA	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous **melanocortin-4 receptor (MC4-R**) agonist .

HY-P1478

Adrenocorticotropic Hormone (ACTH) (4-10), human	Melanocortin Receptor	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent **melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀**=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P3561

Agouti-related Protein (AGRP) (83-132) Amide (human)	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the **melanocortin-4 receptor** (MC4R) to increase food intake .

HY-P1216

HS014	Melanocortin Receptor	Neurological Disease
HS014 is a potent and selective **melanocortin-4 (MC4) receptor antagonist, with K_i*s of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors*, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats .

HY-P2242

RO27-3225	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 shows 30-fold selectivity for MC4R over MC3R. RO27-3225 has neuroprotective and anti-inflammatory effects .

HY-P1216A

HS014 TFA 1 Publications Verification	Melanocortin Receptor	Neurological Disease
HS014 TFA is a potent and selective **melanocortin-4 (MC4) receptor antagonist, with K_i*s of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors* respectively. HS014 TFA increases food intake in free-feeding rats .

HY-19870A

Setmelanotide TFA RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent **melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀**=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P81900

	MC4R Antibody (YA1645) MC4R; melanocortin 4 receptor	WB	Human, Mouse, Rat
	MC4R Antibody (YA1645) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MC4R.

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