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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
nitroreductase
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "nitroreductase" in MCE Product Catalog:
1
Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS) .
PROTAC EGFR degrader 2 is an EGFR-targeting PROTAC and antitumor agent. PROTAC EGFR degrader 2 induces degradation of EGFR protein via the ubiquitin-proteasome system, requiring binding to both EGFR and the VHL E3 ubiquitin ligase. PROTAC EGFR degrader 2 exerts antitumor efficacy following EGFR degradation. PROTAC EGFR degrader 2 is released from the NTR-responsive caged-PROTAC 17-1 upon activation by nitroreductase in hypoxic tumor tissues. PROTAC EGFR degrader 2 can be used for the research of non-small cell lung cancer .
Cat. No.: HY-P4545
CAS No.: 67482-93-3
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Cat. No.: HY-P4561
CAS No.: 90331-82-1
Cat. No.: HY-P4725
CAS No.: 133233-38-2
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Cat. No.: HY-D1450
CAS No.: 155613-98-2
Synonyms: S01448
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IR-1048 is a nitroreductase (NTR)-responsive near-infrared fluorescence (NIR)/photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment, restoring strong near-infrared absorption and fluorescence emission (NIR II window), while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching, achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment .
Cat. No.: HY-149836
Purity: 98.07%
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3-MeOARh-NTR is an activatable imaging probe with high selectivity, and good stability. 3-MeOARh-NTR possesses high selectivity and high signal-to-noise ratio for nitroreductase (NTR) detection, and serves as an efficient molecular tool for endogenous NTR detection .
Cat. No.: HY-149769
CAS No.: 2227303-52-6
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CP-506 (compound 26) is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity .
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Disperse red 167:1 (DR 167:1) is an azo disperse dye . Disperse red 167:1 interacts with the active site of nitroreductase, leading to the reduction of its nitro group to amine metabolites. Disperse red 167:1 is mainly used for dyeing hydrophobic fibers such as polyester, and is also applicable to dyeing research on plastics, textiles and other materials .
Cat. No.: HY-149769A
CAS No.: 2227304-19-8
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CP-506 (compound 26) mesylate is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity .
Cat. No.: HY-D2729
CAS No.: 3012597-48-4
Cat. No.: HY-170436
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NFh-NMe-2 is a photosensitizer, that interacts with nitroreductase, generates singlet oxygen in tumor cells, exhibits cytotoxicity in cancer cells, and induces apoptosis. NFh-NMe-2 exhibits antitumor efficacy in mouse models .
Cat. No.: HY-149836A
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3-MeOARh-NTR chloride is an activatable imaging probe with high selectivity, and good stability. 3-MeOARh-NTR chloride possesses high selectivity and high signal-to-noise ratio for nitroreductase (NTR) detection, and serves as an efficient molecular tool for endogenous NTR detection .
Cat. No.: HY-P4556
CAS No.: 50572-79-7
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Cat. No.: HY-135470R
CAS No.: 13411-16-0
Synonyms: P-7138 (Standard)
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Nifurpirinol (P-7138) (Standard) is the analytical standard of Nifurpirinol (HY-135470). This product is intended for research and analytical applications. Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS) .
Cat. No.: HY-P703427
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ydgI; BSU05660; Putative NAD; PH nitroreductase YdgI; EC 1.-.-.-; Putative NAD(P)H nitroreductase YdgI; Bacillus subtilis (strain 168); Oxidoreductase
Species:
Others
Source:
E. coli
Cat. No.: HY-D3240
CAS No.: 2375541-43-6
Cat. No.: HY-D3167
CAS No.: 1616863-09-2
Cat. No.: HY-175163
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TPAPyN is a nitroreductase(NTR)-responsive type I photosensitizer. TPAPyN facilitates the imaging of hypoxic cancer cells and image-guided photodynamic therapy (PDT). TPAPyN does not emit fluorescence in the aqueous environment, but restores when NTR cleaves the nitrofuran quencher with aggregation-induced emission. TPAPyN can be used as a fluorescent probe for specific imaging of hypoxic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
