12 Results for "

nuclear extracts

" in MedChemExpress (MCE) Product Catalog:
Products (12)

12 Results for "nuclear extracts" in MCE Product Catalog:

1
Oroxylin A-7-O-glucuronide
Oroxylin A-7-O-glucuronide
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1 Cited Publications
Cat. No.: HY-N2481
CAS No.: 36948-76-2
Synonyms: Oroxyloside; Oroxylin A-7-O-β-D-glucuronide
Category:  

Flavonoids Monophenols Neurological Disease Flavones Phenols Plants Disease Research Fields Medicago truncatula Gaertn. Labiatae Extract

Target:  

Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related

Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .
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Gynostemma Extract
Gynostemma Extract
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1 Cited Publications
Cat. No.: HY-N0167
CAS No.: 80321-63-7
Synonyms: Ginsenoside C-Mx1; Gypenoside IX
Category:  

Triterpenes Terpenoids Cucurbitaceae Extract Plants Endogenous metabolite Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer

Target:  

p38 MAPK Akt NF-κB COX Interleukin Related NO Synthase

Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation .
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Triptophenolide
Triptophenolide
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Cat. No.: HY-N0475
CAS No.: 74285-86-2
Synonyms: Hypolide; (+)-Triptophenolide
Category:  

Monophenols Celastraceae Extract Terpenoids Other Diseases Phenols Diterpenoids Plants Tripterygium wilfordii Hook. f. Disease Research Fields

Target:  

Androgen Receptor Pyroptosis Caspase Bcl-2 Family Apoptosis

Triptophenolide (Hypolide) is a colorless crystal isolated from the ethyl acetate extract of Tripterygium wilfordii. Triptophenolide is an orally active pan‑antagonist of the androgen receptor (AR) with an IC50 of 467 nM against human wild‑type AR. Triptophenolide reduces AR expression, inhibits AR nuclear translocation, downregulates prostate‑specific antigen mRNA levels, and suppresses the growth of AR‑positive prostate cancer cells. Triptophenolide shows anti-tumor effects against breast cancer by inhibiting cell proliferation and migration, inducing G1-phase arrest and apoptosis, repressing xenograft tumor growth. Triptophenolide inhibits pyroptosis, alleviates tissue inflammation, and ameliorates synovial injury. Triptophenolide can be used for the study of prostate cancer, rheumatoid arthritis and breast cancer .
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cp028
cp028
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Cat. No.: HY-136951
CAS No.: 347397-83-5
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

cp028 is a potent pre-mRNA splicing inhibitor. cp028 inhibits splicing in HeLa nuclear extract with an IC50 value of 54 µM .
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BDS-I
BDS-I
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Cat. No.: HY-P5156
CAS No.: 207621-38-3
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death .
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Licoflavanone
Licoflavanone
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Cat. No.: HY-N10133
CAS No.: 119240-82-3
Synonyms: 3′-Prenylnaringenin
Category:  

Glycyrrhiza glabra Linn. Flavonoids Flavonones Leguminosae Extract Plants

Target:  

Bacterial mTOR Akt PI3K NF-κB Caspase JNK ERK COX NO Synthase Apoptosis

Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms .
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NOT Receptor Modulator 1
NOT Receptor Modulator 1
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Cat. No.: HY-U00429
CAS No.: 1015231-98-7
Target:  

Nuclear Hormone Receptor 4A/NR4A

Research Areas:  

Neurological Disease

NOT Receptor Modulator 1 is a nuclear receptor Nurr-1/NOT modulator extracted from patent WO 2008034974 A1, Example 39 in table1.
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Oroxylin A-7-O-glucuronide (Standard)
Oroxylin A-7-O-glucuronide (Standard)
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Cat. No.: HY-N2481R
CAS No.: 36948-76-2
Synonyms: Oroxyloside (Standard); Oroxylin A-7-O-β-D-glucuronide (Standard)
Category:  

Flavonoids Monophenols Flavones Phenols Plants Medicago truncatula Gaertn. Labiatae Extract

Target:  

Reference Standards Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related

Oroxylin A-7-O-glucuronide (Standard) is the analytical standard of Oroxylin A-7-O-glucuronide (HY-N2481). This product is intended for research and analytical applications. Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .
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p21PBP
p21PBP
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Cat. No.: HY-P10825
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

p21PBP, a 20 amino-acid peptide, is an inhibitor of DNA replication. p21PBP specifically binds to purified proliferating cell nuclear antigen (PCNA) in tumour cell extracts. p21PBP is promising for research of cancers .
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Tibesaikosaponin V
Tibesaikosaponin V
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Cat. No.: HY-N11507
CAS No.: 2319668-87-4
Synonyms: TKV
Category:  

Sonchus asper (L.) Hill Triterpenes Umbelliferae Extract Terpenoids Plants

Target:  

PPAR

Tibesaikosaponin V (TKV) is a triterpene diglycoside, which can be isolated from the methanol extract of the roots of Bupleurum chinense DC.. Tibesaikosaponin V inhibits lipid accumulation and triacylglycerol content occurred without cytotoxicity to adipocytes. Tibesaikosaponin V suppresses the mRNA expression of nuclear transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). Tibesaikosaponin V inhibits 3T3-L1 preadipocyte differentiation. Tibesaikosaponin V can be used fro research of obesity and its associated metabolic disorders .
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Triptophenolide (Standard)
Triptophenolide (Standard)
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Cat. No.: HY-N0475R
CAS No.: 74285-86-2
Synonyms: Hypolide (Standard); (+)-Triptophenolide (Standard)
Category:  

Monophenols Celastraceae Extract Terpenoids Phenols Diterpenoids Plants Tripterygium wilfordii Hook. f.

Target:  

Reference Standards Androgen Receptor Pyroptosis Caspase Bcl-2 Family Apoptosis

Triptophenolide (Standard) (Hypolide) is the analytical standard of Triptophenolide (HY-N0475). This product is intended for research and analytical applications. Triptophenolide is a colorless crystal isolated from the ethyl acetate extract of Tripterygium wilfordii. Triptophenolide is an orally active pan‑antagonist of the androgen receptor (AR) with an IC50 of 467 nM against human wild‑type AR. Triptophenolide reduces AR expression, inhibits AR nuclear translocation, downregulates prostate‑specific antigen mRNA levels, and suppresses the growth of AR‑positive prostate cancer cells. Triptophenolide shows anti-tumor effects against breast cancer by inhibiting cell proliferation and migration, inducing G1-phase arrest and apoptosis, repressing xenograft tumor growth. Triptophenolide inhibits pyroptosis, alleviates tissue inflammation, and ameliorates synovial injury. Triptophenolide can be used for the study of prostate cancer, rheumatoid arthritis and breast cancer .
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Azumamide E
Azumamide E
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Cat. No.: HY-P2044
CAS No.: 585535-37-1
Category:  

Cyclopeptides Marine natural products Sponge

Target:  

HDAC

Azumamide E is a HDAC inhibitor, with an IC50 of 0.064 μM against HDAC, 1.22 μM against HDAC1, and 2.28 μM against HDAC4. Azumamide E inhibits HDAC activity in nuclear extracts of leukemia cells and cervical adenocarcinoma cells. Azumamide E suppresses angiogenesis. Azumamide E is applicable for research on leukemia, cervical adenocarcinoma, and anti-angiogenesis .
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