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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
176 Results for "
peptide probes
" in MedChemExpress (MCE) Product Catalog:
Products (176)
176 Results for "peptide probes" in MCE Product Catalog:
15
15 Publications Verification
Cat. No.: HY-16993
CAS No.: 1801787-56-3
OICR-9429, a chemical probe, is high affinity WD repeat domain 5 (WDR5) inhibitor, competitively blocks WDR5 interaction with MLL protein via binding the central peptide-binding pocket of WDR5. OICR-9429 can suppress histone H3K4 trimethylation and can be used for the research of various cancers including non-MLL-rearranged leukaemia, colon, pancreatic, prostate cancer and bladder cancer (BCa) .
11
11 Cited Publications
Cat. No.: HY-19313
CAS No.: 1793053-37-8
Target:
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LLY-507 is a potent and selective inhibitor of protein-lysine methyltransferase SMYD2. LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC50 <15 nM. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes .
7
7 Cited Publications
Research Areas:
A-366, a chemical probe, is a potent, highly selective, peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP (EHMT1), respectively. A-366 shows >1000-fold selectivity over 21 other methyltransferases. A-366 is also a potent, nanomolar inhibitor of the Spindlin1-H3K4me3-interaction (IC50=182.6 nM). A-366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the histaminergic and dopaminergic receptor families .
5
5 Cited Publications
Cat. No.: HY-15940
CAS No.: 72088-94-9
Synonyms: 5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers
4
4 Cited Publications
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MRK-560, a chemical probe, is an orally active, brain barrier-penetrated γ-Secretase inhibitor, reducing Aβ peptide in rat brain and cerebrospinal fluid. MRK-560 decreases mutant NOTCH1 processing by selectively inhibiting PSEN1. MRK-560 can be used in studies of Alzheimer's disease and T-cell acute lymphoblastic leukaemia (T-ALL) .
1
1
1 Cited Publications
Cat. No.: HY-D2186
CAS No.: 2095485-22-4
Cat. No.: HY-NP080
Synonyms: SNA
Cat. No.: HY-D0154
CAS No.: 80724-20-5
Synonyms: Tetramethylrhodamine-6-isothiocyanate
Cat. No.: HY-P11446
CAS No.: 254729-66-3
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Cat. No.: HY-P5287
CAS No.: 393781-65-2
Cat. No.: HY-W400925
CAS No.: 1481447-40-8
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Sulfo-Cy5-N3 is an azide-functionalized sulfonated cyanine 5 Fluorescent dye and also serves as click chemistry coupling reagent. Sulfo-Cy5-N3 undergoes copper (I)-catalyzed azide-alkyne cycloaddition with alkyne-functionalized antibody constructs and peptide probes for site-selective fluorescent labeling. Sulfo-Cy5-N3 also acts as an emission dye for STORM super-resolution imaging. Sulfo-Cy5-N3 is applicable to the study of HER2-positive breast cancer .
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BAY-6035, a chemical probe, is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM .
Cat. No.: HY-NP087
Synonyms: LCA
Cat. No.: HY-W024615
CAS No.: 25055-86-1
Synonyms: 3-(3-Methyl-3H-diazirin-3-yl)propanoic acid
Research Areas:
Me-diazirine-cooh (3-(3-Methyl-3H-diazirin-3-yl) propanoic acid) is a molecular building block containing an aliphatic diazirine ring. Me-diazirine-cooh undergoes orthogonal coupling in solid-phase peptide synthesis to introduce the Diazirine group into collagen-mimetic peptides. Me-diazirine-cooh is used to construct the photoaffinity probe P1 .
Synonyms: ABAO
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2-Amino benzamidoxime (ABAO) acts as a bioconjugation reagent precursor and a fluorescent probe precursor. 2-Amino benzamidoxime contains an aniline group for imine activation of aldehydes, as well as a nucleophilic group (Nu:) located at the ortho position of the amine, which is responsible for intramolecular cyclization. 2-Amino benzamidoxime reacts with glyoxal at the N-terminus of phage-displayed peptide libraries. Derivatives of 2-Amino benzamidoxime can be used for protein bioconjugation. Derivatives of 2-Amino benzamidoxime serve as fluorescent probes .\n
Cat. No.: HY-W103047
CAS No.: 3443-45-6
Research Areas:
1-Pyrenebutyric acid is a pyrene-based fluorescent probe compound. The fluorescence lifetime of 1-Pyrenebutyric acid is quenched by molecular oxygen and intracellular ROS, thus it serves as a fluorescent probe for detecting ROS and oxygen concentration through fluorescence lifetime measurements. 1-Pyrenebutyric acid undergoes electrostatic interactions with arginine-rich peptides, increasing their net hydrophobicity, promoting their direct translocation across lipid bilayers, and enhancing cytosolic delivery. 1-Pyrenebutyric acid is used for intracellular reactive oxygen species detection and research related to arginine-rich peptide-mediated cytosolic delivery .
Cat. No.: HY-P10649A
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Cat. No.: HY-NP0159
Synonyms: WGA (Rhodamine)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
