35 Results for "

polypeptide chains

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "polypeptide chains" in MCE Product Catalog:

17
17 Publications Verification
Referencia número: HY-P1156
No. CAS: 11070-73-8
Target:  

Insulin Receptor

Áreas de investigación:  

Metabolic Disease Endocrinology

Insulin cattle is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells.
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5
5 Cited Publications
Referencia número: HY-P2974
No. CAS: 39445-21-1
Synonyms: EC 3.4.21.36; Pancreatopeptidase E
Target:  

Elastase

Áreas de investigación:  

Metabolic Disease

Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters .
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3
3 Cited Publications
Referencia número: HY-113225B
No. CAS: 103192-46-7
Synonyms: GTP tritris solution (100 mM)
Áreas de investigación:  

Cancer

Guanosine triphosphate tritris (GTP tritris) (100 mM) serves as a vital enhancer of myogenic cell differentiation and plays a critical role in modulating miRNA-myogenic regulator factors. It also facilitates the release of exosomes enriched with guanosine and guanosine-derived molecules, and is regarded as an activated precursor for RNA synthesis. In mitochondrial function, GTP participates in the import of proteins into the matrix, which is essential for various regulated pathways, and is involved in initiating peptide synthesis through the binding of formylmethionyl-tRNA to the ribosome, as well as polypeptide chain elongation. Additionally, GTP acts as a phosphate and pyrophosphate carrier that channels chemical energy into specific biosynthetic pathways. It activates signal transducing G proteins that regulate cellular processes such as proliferation and differentiation, and its hydrolysis by small GTPases, including Ras and Rho, is integral to both proliferation and apoptosis. Furthermore, the small GTPase Rab is instrumental in vesicle docking, fusion, and formation. Beyond signal transduction, GTP is an energy-rich precursor in the enzymatic biosynthesis of DNA and RNA.
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1
1 Cited Publications
Referencia número: HY-A0162
No. CAS: 120138-50-3
Target:  

Bacterial

Áreas de investigación:  

Infection

Quinupristin is a streptogramin antibiotic. Quinupristin blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits .
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1
1 Cited Publications
Referencia número: HY-P10284
No. CAS: 853248-13-2
Áreas de investigación:  

Cardiovascular Disease Cancer

S7 is an inhibitory polypeptide targeting IL-6R, which specifically binds to IL-6R and its A chain (gp80/IL-6RA) to block its signal transduction. S7 inhibits IL-6-mediated anti-apoptosis (apoptosis), angiogenesis and the expression of VEGF-A, blocks related survival signaling pathways, and enhances the sensitivity of cancer cells to chemotherapeutic drugs. S7 can be applied to the research of related diseases such as cervical cancer, multiple myeloma, Kaposi's sarcoma, prostate cancer and basal cell carcinoma .
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1
1 Cited Publications
Referencia número: HY-P0302
No. CAS: 688805-40-5
HEX3 is a fragment of the adenoviral hexon. Hexon is the major capsid protein of adenovirion and is comprised of three identical polypeptide chains.
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Referencia número: HY-129046C
Synonyms: Ribonuclease B, Bovine Pancreas
Áreas de investigación:  

Endocrinology Cancer

RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability. RNase B, Bovine Pancreas (Ribonuclease B, Bovine Pancreas) is the N-glycosylated form of RNase A. RNase B, Bovine Pancreas can promote the folding of polypeptide chains and play a role similar to molecular chaperones .
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Referencia número: HY-W011819
No. CAS: 821-38-5
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid is an endogenous biomarker for assessing the activity of organic anion transporting polypeptides (OATPs) .
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Referencia número: HY-E70004
No. CAS: 9068-59-1
Áreas de investigación:  

Others

Microbial neutral proteinase is a zinc-containing metalloproteinase mainly produced by Bacillus and fungi. Its catalytic activity is highly dependent on divalent cations, and it remains active within the pH range of 5-8. Microbial neutral proteinase can specifically cleave peptide bonds within polypeptide chains, thereby degrading macromolecular proteins into small peptides or amino acids. It can be applied in various industrial fields including food processing, brewing, detergents, and light industry .
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Referencia número: HY-164166
No. CAS: 2749824-37-9
Fmoc-Sar-Sar-Sar-OH is a small molecule polypeptide composed of sarcosine residues, in which the N-terminus of the peptide chain is protected by Fmoc. Fmoc-Sar-Sar-Sar-OH can be used for peptide synthesis or synthesis of agent-peptide ligand conjugates .
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Referencia número: HY-P2980
No. CAS: 11075-17-5
Synonyms: EC 3.4.2.1
Target:  

Endogenous Metabolite

Áreas de investigación:  

Others

Carboxypeptidase A, Bovine pancreas (EC 3.4.2.1) is a zinc-containing metalloprotease, is often used in biochemical studies. Carboxypeptidase A catalyzes the hydrolysis of the peptide bonds that are adjacent to the C-terminal end of a polypeptide chain. Carboxypeptidase A is a prototypical enzyme for metalloproteases that plays important roles in biological systems .
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Referencia número: HY-W011819S
No. CAS: 130348-88-8
Tetradecanedioic acid-d24 is the deuterium labeled Tetradecanedioic acid . Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions .
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Referencia número: HY-157745
No. CAS: 92451-01-9
Pureza:  ≥98.0%
Synonyms: mPEG40000-SC; mPEG40000-Succinimidyl ester
Áreas de investigación:  

Others

m-PEG-NHS ester (mPEG-SC; mPEG-Succinimidyl ester) (MW 40000) is a polyethylene glycol derivative. m-PEG-NHS ester serves as a modifying agent that reacts with free amino groups on the surface of protein or polypeptide molecules to form stable amide bonds, thereby covalently linking PEG chains to biomacromolecules, improving their antigenicity and immunogenicity, and facilitating the preparation of injectable formulations .
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Referencia número: HY-W006886
No. CAS: 945212-26-0
Áreas de investigación:  

Others

Fmoc-(R)-2-(7-octenyl) Ala-OH is an unnatural Fmoc-protected amino acid and modification module. Fmoc-(R)-2-(7-octenyl) Ala-OH serves as a key building block for all-hydrocarbon cross-linking modification of antimicrobial peptides, and facilitates the generation of stapled peptide derivatives. When introduced into specific sites of the parent peptide, Fmoc-(R)-2-(7-octenyl) Ala-OH effectively increases the α-helix content of the peptide chain, thereby significantly enhancing its antimicrobial activity and proteolytic stability. Fmoc-(R)-2-(7-octenyl) Ala-OH is widely used in research on bacterial infections and the development of related antimicrobial agents . Stapled peptide is a specially chemically modified polypeptide. It locks the peptide chain into a stable α-helical structure by introducing a "staple"-like chemical bridge (usually an all-carbon backbone) at specific positions of the peptide chain.
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Referencia número: HY-W020784
No. CAS: 102849-12-7
Áreas de investigación:  

Others

3-(N-Maleimidopropionyl)biocytin is a cysteine-specific labeling reagent and non-membrane-permeable probe. 3-(N-Maleimidopropionyl)biocytin covalently modifies the exposed cysteine residues of yeast Tim44, conjugating the biotin moiety to the polypeptide chain. 3-(N-Maleimidopropionyl)biocytin determines the topology of membrane proteins by modifying the exposed cysteine residues on the outer side of the inner mitochondrial membrane .
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Referencia número: HY-A0155
No. CAS: 32988-50-4
Target:  

Antibiotic Bacterial

Áreas de investigación:  

Infection

Viomycin is a potent antibiotic against Mycobacteria. Viomycin rapidly inhibits polypeptide chain elongation when added to purified endogenous Escherichia coli polysomes actively engaged in polypeptide synthesis .
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Referencia número: HY-P5723A
Target:  

Bacterial

Áreas de investigación:  

Infection

Api137 TFA is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 TFA inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain .
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Referencia número: HY-P1538A
No. CAS: 61533-47-9
Synonyms: Human fibrinopeptide A TFA
Target:  

Peptides

Áreas de investigación:  

Cardiovascular Disease

Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain .
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Referencia número: HY-A0155B
Target:  

Antibiotic Bacterial

Áreas de investigación:  

Infection

Viomycin sulfate hydrate is a potent antibiotic against Mycobacteria. Viomycin sulfate hydrate rapidly inhibits polypeptide chain elongation when added to purified endogenous Escherichia coli polysomes actively engaged in polypeptide synthesis .
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Referencia número: HY-P1537
No. CAS: 179986-89-1
Áreas de investigación:  

Metabolic Disease Endocrinology

Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4.
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