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Results for "

protein kinase C (PKC)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PKC (131) 5-HT Receptor (4) Akt (4) AMPK (4) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (6) Apoptosis (27) Aquaporin (1) Arp2/3 Complex (1) Autophagy (2) Bacterial (4) Bcl-2 Family (2) Biochemical Assay Reagents (2) c-Kit (4) Cadherin (1) Calcium Channel (4) Caspase (3) CDK (5) CMV (2) Cytochrome P450 (2) DOCK (3) Dopamine β-hydroxylase (2) Drug Derivative (2) Drug Metabolite (3) Endogenous Metabolite (17) ERK (2) Estrogen Receptor/ERR (3) Fluorescent Dye (1) Fungal (3) HBV (2) HIV (2) IKK (1) Influenza Virus (5) Interleukin Related (1) Isotope-Labeled Compounds (8) JNK (2) MARCKS (2) mGluR (2) Monoamine Oxidase (3) mRNA (2) Myosin (5) NF-κB (2) NO Synthase (3) NOD-like Receptor (NLR) (3) Nucleoside Antimetabolite/Analog (2) Orthopoxvirus (7) p38 MAPK (2) Phosphatase (4) PI3K (5) PKA (11) PKD (1) PKG (1) Pregnane X Receptor (PXR) (1) Ras (1) Reactive Oxygen Species (ROS) (3) Reference Standards (19) Reverse Transcriptase (3) ROCK (4) SARS-CoV (1) Sirtuin (4) SphK (1) Syk (1) Telomerase (2) Topoisomerase (8) TRP Channel (2) VEGFR (3)
By Research Areas:	Cancer (81) Cardiovascular Disease (9) Endocrinology (1) Infection (23) Inflammation/Immunology (30) Metabolic Disease (7) Neurological Disease (19)
Oligonucleotides:	Phospholipids (1) mRNA (2) Antisense Oligonucleotides (1)

138

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: PKC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15141

Staurosporine 205+ Cited Publications Antibiotic AM-2282; STS; AM-2282	PKC PKA Apoptosis Bacterial Fungal Antibiotic	Infection Cancer
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for *PKC, PKA, c-Fgr, and Phosphorylase kinase* respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-13434

Ionomycin 115+ Cited Publications SQ23377	Calcium Channel PKC Bacterial Apoptosis Antibiotic	Infection Cancer
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-10230

Midostaurin 35+ Cited Publications PKC412; CGP 41251	PKC VEGFR c-Kit NO Synthase Apoptosis	Cancer
Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, *c-Kit, c-Fgr, c-Src, FLT3, PDFRβ* and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-12359

TPPB 1 Publications Verification	MARCKS PKC	Neurological Disease
TPPB is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a K_i of 11.9 nM.

HY-N0453

Hypericin 5+ Cited Publications	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of *PKC* (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-101569

Darovasertib 4 Publications Verification LXS196; IDE196	PKC	Cancer
Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC₅₀ values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research .

HY-101047

D-erythro-Sphingosine 4 Publications Verification Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of *p32-kinase* with an EC₅₀ of 8 μM, and inhibits **protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A** activator .

HY-10183

Go6976 10+ Cited Publications	PKC Influenza Virus	Cancer
Go6976 is a Protein Kinase C (PKC) inhibitor, with an IC₅₀ of 20 nM.

HY-12598A

DHPG 4 Publications Verification (RS)-3,5-DHPG	mGluR	Neurological Disease
DHPG is the agonist for mGluR 1/5 (EC₅₀ for mGluR 1 is 60 nM) that activates the phospholipase C (PLC) pathway, and leads ultimately to the activation of protein kinase C (PKC) .

HY-112782

VTX-27	PKC	Inflammation/Immunology
VTX-27 is a selective protein kinase C θ *(PKC* θ) inhibitor, with K_is** of 0.08 nM and 16 nM for PKC θ and PKC δ.

HY-132304

CC-90005	PKC	Inflammation/Immunology
CC-90005 is a potent, selective and orally active inhibitor of **protein kinase C-θ (PKC-θ), with an IC₅₀** of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC₅₀=4440 nM). CC-90005 can inhibit T cell activation by inhibiting IL-2 expression .

HY-P1821

Myelin Basic Protein 2 Publications Verification MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-108355

R59949 1 Publications Verification	PKC	Cancer
R59949 is a pan *diacylglycerol kinase* (DGK) inhibitor with an IC₅₀** of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C *(PKC)* by enhancing the levels of the endogenous ligand diacyl glycerol .

HY-100984

HA-100 1 Publications Verification	PKA PKC Myosin ROCK	Cancer
HA-100 is a potent **protein kinase inhibitor, with IC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK** inhibitor .

HY-118384

Sangivamycin 3 Publications Verification NSC 65346; BA-90912	PKC Nucleoside Antimetabolite/Analog	Cancer
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of **protein kinase C (PKC) with an K_i** of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .

HY-126146

PKC-iota inhibitor 1 2 Publications Verification	PKC AMPK	Metabolic Disease Cancer
PKC-iota inhibitor 1 is a **protein kinase C-iota (PKC-ι) inhibitor with an IC₅₀** value of 0.34 μM. PKC-iota inhibitor 1 can be used for the study of cancer .

HY-100983

Protein kinase inhibitor H-7 dihydrochloride	PKC	Cancer
Protein kinase inhibitor H-7 dihydrochloride is a potent *PKC* (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) .

HY-129624A

Bisindolylmaleimide VIII acetate 1 Publications Verification Ro 31-7549 acetate; Bis VIII acetate	PKC Apoptosis	Inflammation/Immunology Cancer
Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective **protein kinase C (PKC) inhibitor with an IC₅₀** of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC₅₀s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-β_I, PKC-β_II, PKC-γ, PKC-ε, respectively . Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases .

HY-101047S

D-erythro-Sphingosine-d7 1 Publications Verification Erythrosphingosine-d₇; erythro-C18-Sphingosine-d₇; trans-4-Sphingenine-d₇	PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-108391

C8-Ceramide N-Octanoyl-D-erythro-sphingosine	Apoptosis PKC Autophagy	Inflammation/Immunology Cancer
C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of **protein kinase (PKC)** in vitro .

HY-129099A

N-Desmethyltamoxifen hydrochloride	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite	Cancer
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent **protein kinase C (PKC)** inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-126328

PKC-theta inhibitor 1	PKC Interleukin Related	Inflammation/Immunology
PKC-theta inhibitor 1 is an orally active and selective ATP-competitive inhibitor of Protein Kinase Cθ (PKCθ), with a K_i value of 6 nM. PKC-theta inhibitor 1 inhibits T-cell-mediated inflammatory responses by suppressing the release of proinflammatory cytokines (IL-2 IC₅₀ = 0.21 μM in anti-CD3/CD28-stimulated PBMCs; IL-17 IC₅₀ = 1 μM in CD3/CD28-stimulated Th17 cells) PKC-theta inhibitor 1 significantly reduces symptoms in mice with ongoing experimental autoimmune encephalomyelitis (EAE). PKC-theta inhibitor 1 can be used for the study of T-cell-mediated inflammatory diseases such as multiple sclerosis .

HY-P1746

Protein Kinase C (19-31) 1 Publications Verification PKC (19-31)	PKC	Inflammation/Immunology
Protein Kinase C (19-31), a peptide inhibitor of **protein kinase C (PKC)*, derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein* kinase C substrate peptide for testing the protein kinase C activity .

HY-131900

Protein kinase inhibitor H-7	PKC PKA PKG Arp2/3 Complex	Others
Protein kinase inhibitor H-7 is a selective inhibitor of *PKC* and cyclic nucleotide-dependent protein kinases, with a K_i value of 6.0 μM for rabbit protein kinase C, a K_i value of 3.0 μM for rabbit cAMP-dependent protein kinase, and a K_i value of 5.8 μM for porcine cGMP-dependent protein kinase. Protein kinase inhibitor H-7 has no effect on Ca ²⁺-calmodulin-dependent enzymes. Protein kinase inhibitor H-7 regulates the Actin cytoskeleton, inhibits contractility, disrupts stress fibers, induces protrusive activity, stabilizes intercellular junctions, and triggers rapid and reversible cytoskeletal reorganization. Protein kinase inhibitor H-7 serves as a research tool for elucidating the functions of protein kinase C-mediated signaling systems .

HY-108262

UCN-02 7-epi-Hydroxystaurosporine	PKC PKA	Cancer
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor with a PKC IC₅₀ value of 62 nM and a PKA IC₅₀ value of 0.25 μM. UCN-02 can be produced by Streptomyces strain N-126. UCN-02 can be used for the research of breast carcinoma .

HY-137295

Ingenol 3,20-dibenzoate	PKC Apoptosis	Inflammation/Immunology
Ingenol 3,20-dibenzoate is a potent **protein kinase C (PKC)** isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-117393

Bisindolylmaleimide III 1 Publications Verification	PKC	Cancer
Bisindolylmaleimide III is a potent and selective inhibitor of **protein kinase C (PKC)*. Bisindolylmaleimide III selectively interacts with either PKCα or ribosomal S6 protein* kinase 1 after activation of these kinases .

HY-148413

Aprinocarsen sodium 1 Publications Verification ISIS 3521 sodium	PKC	Cancer
Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers .

HY-15141R

Staurosporine (Standard) Antibiotic AM-2282 (Standard); STS (Standard); AM-2282 (Standard)	Reference Standards PKC PKA Apoptosis Bacterial Fungal Antibiotic	Infection Cancer
Staurosporine (Standard) is the analytical standard of Staurosporine. This product is intended for research and analytical applications. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].

HY-P1288

Protein Kinase C (530-558) PKC fragment (530-558)	PKC	Others
Protein Kinase C (530-558), a peptide fragment of protein kinase C (PKC), is a potent *PKC* activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption .

HY-128142

PKC/PKD-IN-1	PKD PKC	Cardiovascular Disease
PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D (PKC/PKD) inhibitor with an IC₅₀ value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure .

HY-P1821A

Myelin basic protein (4-14) TFA 2 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-129980

NPC-15437 dihydrochloride	PKC	Neurological Disease
NPC-15437 dihydrochloride is a selective, penetrable and reversible **protein kinase C (PKC) inhibitor, with an IC₅₀** of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation .

HY-N11003

Vanicoside A 1 Publications Verification	PKC Reactive Oxygen Species (ROS)	Cancer
Vanicoside A is a phenylpropanoid glycoside. Vanicoside A can be isolated from Polygonum pensylvanicum. Vanicoside A inhibits **protein kinase C (PKC), induces substantial ROS** production. Vanicoside A exhibits anticancer activity against melanoma .

HY-129099

N-Desmethyltamoxifen	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite	Cancer
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent **protein kinase C (PKC)** inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-P1402

[Glu27]-PKC (19-36)	PKC	Others
[Glu27]-PKC (19-36) is an inactive control for protein kinase C (PKC) (19-36). PKC (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C, it may be responsible for maintaining the enzyme in the inactive form in the absence of allosteric activators such as phospholipids .

HY-P3892

Protein Kinase C (19-35) Peptide	PKC	Inflammation/Immunology
Protein Kinase C (19-35) Peptide is the *PKC* pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of *PKC* inactive .

HY-P1088

[Ser25] Protein Kinase C (19-31)	PKC	Others
[Ser25] Protein Kinase C (19-31) is a substrate of protein kinase C (PKC) (K_m: 0.3 μM). [Ser25] Protein Kinase C (19-31) is derived from the pseudo-substrate regulatory domain of PKCα (19-31) with a Serine at position 25 replacing the wild-type Alanine .

HY-P3940

Ac-MBP (4-14) Peptide	PKC	Others
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .

HY-P3741

[Ala9,10, Lys11,12] Glycogen Synthase (1-12)	PKC	Neurological Disease
[Ala9,10, Lys11,12] Glycogen Synthase (1-12) is a selective substrate for phosphorylation by protein kinase C (PKC). [Ala9,10, Lys11,12] Glycogen Synthase (1-12) can be used to determine the activity of protein kinase C .

HY-10230S

Midostaurin-d5 PKC412-d₅; CGP 41251-d₅	Isotope-Labeled Compounds PKC Syk Akt PKA c-Kit	Cancer
Midostaurin-d₅ (PKC412-d₅) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM .

HY-120515

7-Oxostaurosporine	PKC	Cancer
7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway .

HY-101047R

D-erythro-Sphingosine (Standard) Erythrosphingosine (Standard); erythro-C18-Sphingosine (Standard); trans-4-Sphingenine (Standard)	Reference Standards PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine (Standard) is the analytical standard of D-erythro-Sphingosine. This product is intended for research and analytical applications. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	PKC	Cancer
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent **Protein kinase C (PKC)** inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-117115

1,2-Dihexanoyl-sn-glycerol	Biochemical Assay Reagents	Others
1,2-Dihexanoyl-sn-glycerol is an analog of protein kinase C (PKC) that activates the second messenger diacylglycerol (DAG). Although the biological activity of 1,2-dicaproyl-sn-glycerol has not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol.

HY-E70852

PKCα Recombinant Human Active Protein Kinase	PKC	Cancer
PKC is a family of serine/threonine kinases involved in several processes including proliferation, differentiation, apoptosis, and migration. PKCα is a classical PKC isoform that contains a C1 domain that binds to diacylglycerol (DAG). PKCα Recombinant Human Active Protein Kinase is a recombinant PKCα protein that can be used to study PKCα-related functions .

HY-112384

Safingol L-threo-dihydrosphingosine	PKC	Cancer
Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor .

HY-129330

Sapintoxin D	PKC	Others
Sapintoxin D is a fluorescent phorbol ester that can be used to study the activation of protein kinase C (PKC). Sapintoxin D is a calcium-dependent PKC activator .

HY-P1401

Protein Kinase C (19-36)	PKC	Metabolic Disease
Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of **protein kinase C (PKC), with an IC₅₀** of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response .

HY-P1746A

Protein Kinase C (19-31) TFA PKC (19-31) TFA	PKC	Inflammation/Immunology
Protein Kinase C (19-31) TFA, a peptide inhibitor of **protein kinase C (PKC)*, derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein* kinase C substrate peptide for testing the protein kinase C activity .

Cat. No.	Product Name	Type

HY-D1751

RIM-1	Fluorescent Dyes
RIM-1 is a fluorescent probe for protein kinase C (PKC) that can be used to visualize the distribution of PKC in cells.

HY-D1493

FIM-1	Fluorescent Dyes
FIM-1 is a fluorescent *PKC* (protein kinase C) probe that can be used for mitochondrial staining. FIM-1 inhibits PKC and acts as ATP-competitive catalytic site inhibitor .

Cat. No.	Product Name	Type

HY-143212

18:0-22:6 DG

1-Stearoyl-2-docosahexaenoyl-sn-glycerol

Biochemical Assay Reagents

18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol (DG) that can interact with RasGRP (Ras guanine nucleotide-releasing protein) (K_i = 8.37 μM) and modulate the activation of MAP kinases (such as ERK1/ERK2), which play a crucial role in cellular signaling processes. 18:0-22:6 DG can also activate protein kinase C (PKC) isozyme. 18:0-22:6 DG can be used for research of cancer, immunology and metabolic disease .

HY-117115

1,2-Dihexanoyl-sn-glycerol	Biochemical Assay Reagents
1,2-Dihexanoyl-sn-glycerol is an analog of protein kinase C (PKC) that activates the second messenger diacylglycerol (DAG). Although the biological activity of 1,2-dicaproyl-sn-glycerol has not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol.

HY-W127485

cis-9,10-Methyleneoctadecanoic Acid

Biochemical Assay Reagents

cis-9,10-Methyleneoctadecanoic acid is a cyclopropane fatty acid that has been found in bacteria and in the digestive glands of P. globosa. It is a component of the cell membrane of Staphylococcus aureus, and levels were reduced after treatment with carvacrol. cis-9,10-Methyleneoctadecanoic acid is secreted by H. pylori and enhances histamine- and dibutyryl cAMP-stimulated acid secretion in isolated guinea pig parietal cells. It also activates protein kinase C (PKC) in a calcium-dependent manner.

Cat. No.	Product Name	Target	Research Area

HY-P1821

Myelin Basic Protein 2 Publications Verification MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-P1746

Protein Kinase C (19-31) 1 Publications Verification PKC (19-31)	PKC	Inflammation/Immunology
Protein Kinase C (19-31), a peptide inhibitor of **protein kinase C (PKC)*, derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein* kinase C substrate peptide for testing the protein kinase C activity .

HY-P1288

Protein Kinase C (530-558) PKC fragment (530-558)	PKC	Others
Protein Kinase C (530-558), a peptide fragment of protein kinase C (PKC), is a potent *PKC* activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption .

HY-P1821A

Myelin basic protein (4-14) TFA 2 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-P1402

[Glu27]-PKC (19-36)	PKC	Others
[Glu27]-PKC (19-36) is an inactive control for protein kinase C (PKC) (19-36). PKC (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C, it may be responsible for maintaining the enzyme in the inactive form in the absence of allosteric activators such as phospholipids .

HY-P3892

Protein Kinase C (19-35) Peptide	PKC	Inflammation/Immunology
Protein Kinase C (19-35) Peptide is the *PKC* pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of *PKC* inactive .

HY-P1088

[Ser25] Protein Kinase C (19-31)	PKC	Others
[Ser25] Protein Kinase C (19-31) is a substrate of protein kinase C (PKC) (K_m: 0.3 μM). [Ser25] Protein Kinase C (19-31) is derived from the pseudo-substrate regulatory domain of PKCα (19-31) with a Serine at position 25 replacing the wild-type Alanine .

HY-P3940

Ac-MBP (4-14) Peptide	PKC	Others
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .

HY-P3741

[Ala9,10, Lys11,12] Glycogen Synthase (1-12)	PKC	Neurological Disease
[Ala9,10, Lys11,12] Glycogen Synthase (1-12) is a selective substrate for phosphorylation by protein kinase C (PKC). [Ala9,10, Lys11,12] Glycogen Synthase (1-12) can be used to determine the activity of protein kinase C .

HY-P1401

Protein Kinase C (19-36)	PKC	Metabolic Disease
Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of **protein kinase C (PKC), with an IC₅₀** of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response .

HY-P1746A

Protein Kinase C (19-31) TFA PKC (19-31) TFA	PKC	Inflammation/Immunology
Protein Kinase C (19-31) TFA, a peptide inhibitor of **protein kinase C (PKC)*, derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein* kinase C substrate peptide for testing the protein kinase C activity .

HY-P3879

Protein Kinase C (660-673) PKC βII (660-673)	PKC	Others
Protein Kinase C (660-673) (PKC βII (660-673)) is the PKC βII V5 peptide with RACK1-binding affinity .

HY-P5886

PKC 20-28,myristoylated Myristoylated protein kinase C inhibitor 20-28	PKC	Cancer
PKC 20-28,myristoylated (Myristoylated protein kinase C inhibitor 20-28) is a cell-permeable *PKC* inhibitor that can be used in cancer research .

HY-P3083

N-Myristoyl-Lys-Arg-Thr-Leu-Arg	PKC	Inflammation/Immunology
N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a **protein kinase C (PKC) inhibitor with an IC₅₀** value of 75 μM. N-Myristoyl-Lys-Arg-Thr-Leu-Arg inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat .

HY-P5452

PKCd (8-17)	PKC	Others
PKCd (8-17) is a biological active peptide. (This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.)

HY-P3842

Protein Kinase C (661-671)	PKC	Cancer
Protein Kinase C (661-671) is a fragment peptide of β1 subspecies of protein kinase C (PKC). PKC plays a role in cellular growth control and tumor promotion .

HY-P3766

Protein kinase C (alpha) peptide TFA	PKC	Others
Protein kinase C α peptide (TFA) is a peptide of *PKC-α. PKC-α acts as a lipid-dependent ser/thr protein* kinase, can modulate various cellular processes, including cell survival, proliferation, differentiation, migration, adhesion and so on .

HY-P10821

Myr-Tat-PKCβII	PKC Reactive Oxygen Species (ROS)	Cardiovascular Disease
Myr-Tat-PKCβII is a cell permeable protein kinase C β II peptide inhibitor. Myr-Tat-PKCβII mitigates the generation of reactive oxygen species in rat ex-vivo and porcine in-vivo ischemia-reperfusion injury .

HY-P1289

[Ala113]MBP(104-118)	PKC	Others
[Ala113]MBP(104-118) is an noncompetitive peptide inhibitors of **protein kinase C (PKC), with IC₅₀**s ranging from 28-62 μM .

HY-P1289D

[Ala107]MBP(104-118) acetate	PKC	Others
[Ala107]MBP(104-118) acetate is an noncompetitive peptide inhibitors of **protein kinase C (PKC), with IC₅₀**s ranging from 46-145 μM .

HY-P1289A

[Ala107]MBP(104-118)	PKC	Others
[Ala107]MBP(104-118) is an noncompetitive peptide inhibitors of **protein kinase C (PKC), with IC₅₀**s ranging from 46-145 μM .

HY-P1289C

[Ala113]MBP(104-118) TFA	PKC	Others
[Ala113]MBP(104-118) TFA is an noncompetitive peptide inhibitors of **protein kinase C (PKC), with IC₅₀**s ranging from 28-62 μM .

HY-P1289B

[Ala107]MBP(104-118) TFA	PKC	Others
[Ala107]MBP(104-118) TFA is an noncompetitive peptide inhibitors of **protein kinase C (PKC), with IC₅₀**s ranging from 46-145 μM .

HY-P1399

Pep2m, myristoylated Myr-Pep2m	PKC	Neurological Disease
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC) .

HY-P1399A

Pep2m, myristoylated TFA Myr-Pep2m TFA	PKC	Neurological Disease
Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC) .

HY-P10464

Tat-AKAP79 (326-336)	TRP Channel	Neurological Disease Inflammation/Immunology
TAT-AKAP79 326-336 is a cytoosmotic peptide. TAT-AKAP79 326-336 mimics a specific region on the AKAP79 protein that binds to TRPV1 ion channels (amino acid sequence 326-336). TAT-AKAP79 326-336 inhibits the sensitization of TRPV1 and reduce the overresponse of TRPV1 channels to stimuli caused by the activation of cellular kinases such as protein kinase A (PKA) and protein kinase C (PKC) by inflammatory mediators. TAT-AKAP79 326-336 can be used to study the mechanism of pain transduction and inflammatory hyperalgesia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15141

Staurosporine 205+ Cited Publications Antibiotic AM-2282; STS; AM-2282	Infection Structural Classification Alkaloids Microorganisms Classification of Application Fields Marine natural products Marine microorganism Disease Research Fields Indole Alkaloids Source Classification	PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for *PKC, PKA, c-Fgr, and Phosphorylase kinase* respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-18739

Phorbol 12-myristate 13-acetate Maximum Cited Publications 726 Publications Verification PMA; TPA; Phorbol myristate acetate	Ketones, Aldehydes, Acids Croton tiglium Linn. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	PKC SphK NF-κB
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and **protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress (MCE)**) .

HY-13434

Ionomycin 115+ Cited Publications SQ23377	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-13434A

Ionomycin calcium 115+ Cited Publications SQ23377 calcium	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-13502

Mitoxantrone 45+ Cited Publications Mitozantrone; NSC 301739	Infection Quinones Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-N0453

Hypericin 5+ Cited Publications	Quinones Structural Classification Classification of Application Fields Anthraquinones Guttiferae Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of *PKC* (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-101047

D-erythro-Sphingosine 4 Publications Verification Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	PKC Phosphatase Endogenous Metabolite
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of *p32-kinase* with an EC₅₀ of 8 μM, and inhibits **protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A** activator .

HY-13502A

Mitoxantrone dihydrochloride 45+ Cited Publications Mitozantrone dihydrochloride; NSC 301739 dihydrochloride	Infection Quinones Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-111355B

Cholesteryl sulfate sodium	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Sirtuin Endogenous Metabolite PKC AMPK DOCK
Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions .

HY-N0699

Daphnoretin 3 Publications Verification Dephnoretin; Thymelol	Infection Structural Classification Monophenols Classification of Application Fields Thymelaeaceae Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Source Classification Wikstroemia indica	PKC Influenza Virus NOD-like Receptor (NLR) Apoptosis HBV JNK PI3K Akt CDK Caspase Bcl-2 Family
Daphnoretin (Dephnoretin; Thymelol) is a protein kinase C (PKC) activator that inhibits the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and exhibits antiviral activity. Daphnoretin exerts its antitumor effects by inhibiting the activation of the PI3K/AKT signaling pathway and triggers the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and activation of the NLRP3 inflammasome. Daphnoretin regulates the differentiation and maturation of dendritic cells, inhibits their immunostimulatory function by downregulating the phosphorylation level of JNK, and thus exerts a protective effect in skin graft rejection .

HY-N5072

Desmethylglycitein 3 Publications Verification 4',6,7-Trihydroxyisoflavone	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Phenols Polyphenols Plants Disease Research Fields Isoflavones Source Classification Cancer	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-N5063

Plantainoside D 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Scrophulariaceae Phenylpropanoids Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields Source Classification	Angiotensin-converting Enzyme (ACE) IKK Calcium Channel PKC Reactive Oxygen Species (ROS) NF-κB Apoptosis Sirtuin NOD-like Receptor (NLR)
Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC₅₀ of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension .

HY-111355

Cholesterol sulfate	Structural Classification Animals Steroids Source Classification	Endogenous Metabolite DOCK PKC AMPK Sirtuin
Cholesterol sulfate is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate acts as a DOCK2 inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions .

HY-118384

Sangivamycin 3 Publications Verification NSC 65346; BA-90912	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Cancer Source Classification	PKC Nucleoside Antimetabolite/Analog
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of **protein kinase C (PKC) with an K_i** of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .

HY-129099A

N-Desmethyltamoxifen hydrochloride	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent **protein kinase C (PKC)** inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-N4246

Bacopaside I	Triterpenes Structural Classification Terpenoids Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst. Source Classification	Aquaporin PKC Akt PI3K Apoptosis Monoamine Oxidase Pregnane X Receptor (PXR)
Bacopaside I is an orally active aquaporin AQP1 inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of AQP1 without affecting AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases .

HY-108262

UCN-02 7-epi-Hydroxystaurosporine	Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	PKC PKA
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor with a PKC IC₅₀ value of 62 nM and a PKA IC₅₀ value of 0.25 μM. UCN-02 can be produced by Streptomyces strain N-126. UCN-02 can be used for the research of breast carcinoma .

HY-137295

Ingenol 3,20-dibenzoate	Classification of Application Fields Terpenoids Diterpenoids Euphorbia esula L. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	PKC Apoptosis
Ingenol 3,20-dibenzoate is a potent **protein kinase C (PKC)** isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-15141R

Staurosporine (Standard) Antibiotic AM-2282 (Standard); STS (Standard); AM-2282 (Standard)	Alkaloids Structural Classification Microorganisms Marine natural products Marine microorganism Indole Alkaloids Source Classification	Reference Standards PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine (Standard) is the analytical standard of Staurosporine. This product is intended for research and analytical applications. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].

HY-N0453R

Hypericin (Standard) 5+ Cited Publications	Natural Products Classification of Application Fields Guttiferae Phenols Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Reference Standards Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of *PKC* (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-N11003

Vanicoside A 1 Publications Verification	Polygonaceae Phenols Polyphenols Plants Persicaria orientalis (L.) Spach Source Classification	PKC Reactive Oxygen Species (ROS)
Vanicoside A is a phenylpropanoid glycoside. Vanicoside A can be isolated from Polygonum pensylvanicum. Vanicoside A inhibits **protein kinase C (PKC), induces substantial ROS** production. Vanicoside A exhibits anticancer activity against melanoma .

HY-129099

N-Desmethyltamoxifen	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent **protein kinase C (PKC)** inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-121197

Balanol Ophiocordin; Azepinostatin	Structural Classification Natural Products Microorganisms Source Classification	MARCKS PKA PKC
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive *PKC/PKA* inhibitor against human *PKC* isozymes α, β-I, β-II, γ, δ, ε, η (IC₅₀s=4-9 nM) and ζ (IC₅₀=150 nM). Balanol also blocks the phosphorylation of *cyclic AMP response element-binding protein* (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS)*. Balanol can be isolated from the fungus Verticillium balanoides* .

HY-101047R

D-erythro-Sphingosine (Standard) Erythrosphingosine (Standard); erythro-C18-Sphingosine (Standard); trans-4-Sphingenine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards PKC Phosphatase Endogenous Metabolite
D-erythro-Sphingosine (Standard) is the analytical standard of D-erythro-Sphingosine. This product is intended for research and analytical applications. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	Structural Classification Animals Classification of Application Fields Disease Research Fields Lipid Source Classification Cancer	PKC
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent **Protein kinase C (PKC)** inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-126419

Kobophenol A	Infection Classification of Application Fields Cyperaceae Phenols Polyphenols Plants Disease Research Fields Source Classification Carex kobomugi Ohwi	SARS-CoV PKC
Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC₅₀ of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC₅₀ of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC₅₀ of 52 µM .

HY-129330

Sapintoxin D	Natural Products Euphorbiaceae Shirakiopsis indica (Willd.) Esser Plants Source Classification	PKC
Sapintoxin D is a fluorescent phorbol ester that can be used to study the activation of protein kinase C (PKC). Sapintoxin D is a calcium-dependent PKC activator .

HY-N13747

Chrysosplenol C	Structural Classification Flavonoids Asteraceae Miliusa balansae Finet & Gagnep. Pterocaulon sphacelatum (Labill.) Benth. & Hook.f. ex F.Muell. Plants Annonaceae Other Flavonoids Source Classification	Myosin PKC Calcium Channel
Chrysosplenol C is a type of flavonoid compound. Chrysosplenol C selectively activates cardiac myosin ATPase, with its EC₅₀ being 45 µM. Chrysosplenol C enhances the release of intracellular calcium ions by activating protein kinase C (PKC), thereby increasing the contractility of rat ventricular muscle cells. Chrysosplenol C can be used in the research of heart failure .

HY-N5072R

Desmethylglycitein (Standard) 4',6,7-Trihydroxyisoflavone (Standard)	Structural Classification Flavonoids Leguminosae Glycine max (L.) merr Phenols Polyphenols Plants Isoflavones Source Classification	Reference Standards CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-N4322R

Decursinol angelate (Standard)	Structural Classification Pseudognaphalium affine (D. Don) Anderberg Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Reference Standards PKC
Decursinol angelate (Standard) is the analytical standard of Decursinol angelate. This product is intended for research and analytical applications. Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities .

HY-118384R

Sangivamycin (Standard) NSC 65346 (Standard); BA-90912 (Standard)	Natural Products Microorganisms Source Classification	Reference Standards PKC Nucleoside Antimetabolite/Analog
Sangivamycin (Standard) is the analytical standard of Sangivamycin. This product is intended for research and analytical applications. Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].

HY-N15340

1-Oleoyl-2-linoleoyl-sn-glycerol	Natural Products Endogenous metabolite Source Classification	PKC
1-Oleoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DG). 1-Oleoyl-2-linoleoyl-sn-glycerol can activate protein kinase C (PKC), thus triggering downstream signaling cascades and promoting tumor growth. 1-Oleoyl-2-linoleoyl-sn-glycerol is promising for research of breast cancer .

HY-129099AR

N-Desmethyltamoxifen hydrochloride (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen (hydrochloride) (Standard) is the analytical standard of N-Desmethyltamoxifen (hydrochloride). This product is intended for research and analytical applications. N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].

HY-13502B

Mitoxantrone diacetate Mitozantrone diacetate; NSC 301739 diacetate	Infection Quinones Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone diacetate is a potent topoisomerase II inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone diacetate induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone diacetate shows antitumor activity . Mitoxantrone diacetate also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502AR

Mitoxantrone dihydrochloride (Standard) Mitozantrone dihydrochloride (Standard); NSC 301739 dihydrochloride (Standard)	Quinones Structural Classification Anthraquinones Endogenous metabolite Source Classification	Reference Standards Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone (dihydrochloride) (Standard) is the analytical standard of Mitoxantrone (dihydrochloride). This product is intended for research and analytical applications. Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502R

Mitoxantrone (Standard) Mitozantrone (Standard); NSC 301739 (Standard)	Quinones Structural Classification Anthraquinones Endogenous metabolite Source Classification	Reference Standards Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone (Standard) is the analytical standard of Mitoxantrone. This product is intended for research and analytical applications. Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-N0699R

Daphnoretin (Standard) Dephnoretin (Standard); Thymelol (Standard)	Structural Classification Monophenols Thymelaeaceae Coumarins Phenols Phenylpropanoids Plants Source Classification Wikstroemia indica	Reference Standards PKC NOD-like Receptor (NLR) Apoptosis HBV Caspase Akt JNK PI3K CDK Influenza Virus Bcl-2 Family
Daphnoretin (Dephnoretin; Thymelol) (Standard) is the analytical standard of Daphnoretin (HY-N0699). This product is used for research and analytical applications. Daphnoretin is a protein kinase C (PKC) activator that can inhibit the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and has antiviral activity. Daphnoretin exerts its anti-tumor effect by inhibiting the activation of the PI3K/AKT signaling pathway, triggering the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and the activation of the NLRP3 inflammasome. Daphnoretin can regulate the differentiation and maturation of dendritic cells, by down-regulating the phosphorylation level of JNK, inhibiting its immune stimulating function, thereby playing a protective role in skin transplant rejection reactions.

HY-N9382

Gnidimacrin	Structural Classification Natural Products Thymelaeaceae Stellera chamaejasme Linn. Plants Source Classification	PKC
Gnidimacrin is a protein kinase C (PKC) activator. Gnidimacrin inhibits cell growth of human leukemias, stomach cancers and non-small cell lung cancers in vitro, and shows activity against murine leukemias and solid tumors in vivo. Gnidimacrin can be used for leukemias, stomach cancers and non-small cell lung cancers research .

HY-N18070

12-Deoxyphorbol-13-isobutyrate-20-acetate	Structural Classification Euphorbia resinifera O. Berg Terpenoids Sesquiterpenes Euphorbiaceae Plants Source Classification	Drug Derivative PKC Fungal
12-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a **protein kinase C (PKC)** agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection .

Species:	Human (6)
Tag:	His (2) GST (5)
Source:	Sf9 insect cells (5) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702640

	PRKCG Protein, Human (Active, sf9, GST) PRKCG; protein kinase C, gamma; PKCG, SCA14; protein kinase C gamma type; MGC57564; PKC gamma; PKCC; PKCG; SCA14; PKC-gamma	Human	Sf9 insect cells
	PRKCG Protein, Human (sf9, GST) is the recombinant human-derived PRKCG, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P702639

	PRKCB1 Protein, Human (Active, sf9, GST) PRKCB1; protein kinase C, beta; PKCB, PRKCB1, PRKCB2, protein kinase C, beta 1; protein kinase C beta type; PKC-B; protein kinase C, beta 1 polypeptide; PKCB; PRKCB1; PRKCB2; PKC-beta; MGC41878	Human	Sf9 insect cells
	PRKCB1 Protein, Human (sf9, GST) is the recombinant human-derived PRKCB, expressed by Sf9 insect cells , with GST labeled tag.

HY-P705566

	PRKCB2 Protein, Human (Active, sf9, His-GST) protein kinase C beta type; PKC-B; PKC-beta; PRKCB; PKCB; EC:2.7.11.13	Human	Sf9 insect cells

HY-P702643

	PRKCH Protein, Human (Active, sf9, GST) PKCL; PKC-L; PRKCL; nPKC-eta; protein kinase C eta type	Human	Sf9 insect cells
	PRKCH Protein, Human (sf9, GST) is the recombinant human-derived PRKCH, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P702641

	PRKCA Protein, Human (Active, sf9, GST) 1 Publications Verification PRKCA; protein kinase C alpha; AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha	Human	Sf9 insect cells
	PRKCA Protein, Human (sf9, GST) is the recombinant human-derived PRKCA, expressed by Sf9 insect cells , with N-GST labeled tag. ,

HY-P71229

	PPP1R14A Protein, Human (His) protein Phosphatase 1 Regulatory Subunit 14A; 17 kDa PKC-Potentiated Inhibitory protein of PP1; protein kinase C-Potentiated Inhibitor protein of 17 kDa; CPI-17; PPP1R14A; CPI17; PPP1INL	Human	E. coli
	The PPP1R14A protein is a key cellular regulator that effectively inhibits PPP1CA and exhibits significant activity amplification upon phosphorylation. This phosphorylation-induced transformation turns PPP1R14A into a dynamic molecular switch adept at regulating PPP1CA substrate phosphorylation. PPP1R14A Protein, Human (His) is the recombinant human-derived PPP1R14A protein, expressed by E. coli , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-101047S

D-erythro-Sphingosine-d7 1 Publications Verification
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-111355S

Cholesterol sulfate-d7 sodium

Cholesterol sulfate sodium-d₇ is the deuterium labeled Cholesterol sulfate sodium. Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions.

HY-10230S

Midostaurin-d5
Midostaurin-d₅ (PKC412-d₅) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM .

HY-101047S1

D-erythro-Sphingosine-13C2,d2
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of *p32-kinase* with an EC₅₀ of 8 μM, and inhibits **protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A** activator .

HY-13502S

Mitoxantrone-d8
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM .

HY-W751179

Midostaurin-13C6

Midostaurin- ¹³C₆ (PKC412- ¹³C₆) is the ¹³C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-W751181

O-Desmethyl midostaurin-13C6

O-Desmethyl midostaurin- ¹³C₆ (CGP62221- ¹³C₆; O-Desmethyl PKC412- ¹³C₆) is the ¹³C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor?with?IC₅₀?ranging from 22-500 nM.

HY-13502AS

Mitoxantrone-d8 dihydrochloride

Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502AS1

Mitoxantrone-d8 hydrochloride

Mitoxantrone-d₈ (hydrochloride) (Mitozantrone-d₈ (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

Host:	Rabbit (23)
Reactivity:	Human (23) Rat (17) Mouse (15)
Application:	IHC-P (17) ICC/IF (7) IP (8) WB (21) FC (2) Dot Blot (1) ELISA (3)
Isotype:	IgG (22) IgG/Kappa (1)
Conjugation:	Non-conjugated (23)
Clonality:	Monoclonal (14) Recombinant (10)
Modification:	Phosphorylated (9) Unmodified (7)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86233

	PKC alpha Antibody (YA5925) PRKCA; PKCA; PRKACA; protein kinase C alpha type; PKC-A; PKC-alpha	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PKC alpha Antibody (YA5925) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC alpha.

HY-P810727

	PKC beta Antibody (YA9971) PKCA, PRKACA, PRKCA, protein kinase C alpha type, PKC-A, PKC-alpha	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	PKC beta Antibody (YA9971) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to PKC beta Antibody.

HY-P80435

	PKC gamma Antibody (YA125) PRKCG; PKCG; protein kinase C gamma type; PKC-gamma	WB, ICC/IF	Human, Mouse, Rat
	PKC gamma Antibody (YA125) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC gamma.

HY-P80869

	PKC eta Antibody (YA126) nPKC eta; PKC h; PKC L; PKCh; PKCL; Prkch; PRKCL; protein kinase C eta	WB, IP	Human, Mouse, Rat
	PKC eta Antibody (YA126) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC eta.

HY-P81649

	Phospho-PKC (Ser660) Antibody (YA1394) PRKCA; PKCA; PRKACA; protein kinase C alpha type; PKC-A; PKC-alpha	WB, IHC-P	Human, Rat
	Phospho-PKC (Ser660) Antibody (YA1394) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC (Ser660).

HY-P81298

	Phospho-PKC alpha (Ser657) Antibody (YA1023) PRKCA; PKCA; PRKACA; protein kinase C alpha type; PKC-A; PKC-alpha	WB, IHC-P	Human, Mouse, Rat
	Phospho-PKC alpha (Ser657) Antibody (YA1023) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC alpha (Ser657).

HY-P81298A

	Phospho-PKC alpha (Thr638) Antibody (YA1024) PRKCA; PKCA; PRKACA; protein kinase C alpha type; PKC-A; PKC-alpha	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-PKC alpha (Thr638) Antibody (YA1024) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC alpha (Thr638).

HY-P810623

	Phospho-PKC alpha (Thr497) Antibody (YA9885) PRKCA; PKCA; PRKACA; protein kinase C alpha type; PKC-A; PKC-alpha	WB, ICC/IF, FC	Human, Mouse, Rat
	Phospho-PKC alpha (Thr497) Antibody (YA9885) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-PKC alpha (Thr497).

HY-P86142

	Phospho-PKC alpha(Thr638) Antibody (YA5834) PRKCA; PKCA; PRKACA; protein kinase C alpha type; PKC-A; PKC-alpha	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-PKC alpha(Thr638) Antibody (YA5834) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC alpha(Thr638).

HY-P80869A

	PKC eta Antibody (YA126)(PBS only) nPKC eta; PKC h; PKC L; PKCh; PKCL; Prkch; PRKCL; protein kinase C eta	WB, IP	Human, Mouse, Rat
	PKC eta Antibody (YA126) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC eta.

HY-P81649A

	Phospho-PKC (Ser660) Antibody (YA1394)(PBS only) PRKCA; PKCA; PRKACA; protein kinase C alpha type; PKC-A; PKC-alpha	WB, IHC-P	Human, Rat
	Phospho-PKC (Ser660) Antibody (YA1394) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC (Ser660).

HY-P81298AA

	Phospho-PKC alpha (Thr638) Antibody (YA1024)(PBS only) PRKCA; PKCA; PRKACA; protein kinase C alpha type; PKC-A; PKC-alpha	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-PKC alpha (Thr638) Antibody (YA1024) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC alpha (Thr638).

HY-P82934

	Phospho-PKC zeta (Thr560) Antibody (YA2679) PRKCZ; PKC2; protein kinase C zeta type; nPKC-zeta	WB, IHC-P	Human, Mouse, Rat
	Phospho-PKC zeta (Thr560) Antibody (YA2679) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC zeta (Thr560).

HY-P82886

	Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631) PRKCI; DXS1179E; protein kinase C iota type; PRKCZ; PKC2; protein kinase C zeta type	WB, IHC-P	Human, Mouse
	Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC zeta/lambda (Thr410/Thr412).

HY-P86328

	PKC delta Antibody (YA6020) PRKCD; protein kinase C delta type; Tyrosine-protein kinase PRKCD; nPKC-delta	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PKC delta Antibody (YA6020) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC delta.

HY-P82886A

	Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631)(PBS only) PRKCI; DXS1179E; protein kinase C iota type; PRKCZ; PKC2; protein kinase C zeta type	WB, IHC-P	Human, Mouse
	Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC zeta/lambda (Thr410/Thr412).

HY-P810622

	Phospho-PKC alpha/beta II (Thr638/T641) Antibody (YA9884) PRKCA; PKCA; PRKACA; protein kinase C alpha type; PKC-A; PKC-alpha	WB, IHC-P, ICC/IF, FC, Dot Blot	Human, Mouse, Rat
	Phospho-PKC alpha/beta II (Thr638/T641) Antibody (YA9884) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-PKC alpha/beta II (Thr638/T641).

HY-P82883

	Phospho-PKC delta (Ser299) Antibody (YA2628) protein kinase C delta type; Tyrosine-protein kinase PRKCD; nPKC-delta	WB, IHC-P	Human
	Phospho-PKC delta (Ser299) Antibody (YA2628) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC delta (Ser299).

HY-P81361

	PKC theta Antibody (YA1106) PRKCT; PRKCQ; nPKC-theta; protein kinase C theta type	IHC-P	Human
	PKC theta Antibody (YA1106) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC theta.

HY-P83417

	PKC theta Antibody (YA3162) PRKCQ; PRKCT; protein kinase C theta type; nPKC-theta	WB	Human, Rat
	PKC theta Antibody (YA3162) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC theta.

HY-P82883A

	Phospho-PKC delta (Ser299) Antibody (YA2628)(PBS only) protein kinase C delta type; Tyrosine-protein kinase PRKCD; nPKC-delta	WB, IHC-P, IP	Human
	Phospho-PKC delta (Ser299) Antibody (YA2628) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKC delta (Ser299).

HY-P81361A

	PKC theta Antibody (YA1106)(PBS only) PRKCT; PRKCQ; nPKC-theta; protein kinase C theta type	IHC-P	Human
	PKC theta Antibody (YA1106) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC theta.

HY-P83417A

	PKC theta Antibody (YA3162)(PBS only) PRKCQ; PRKCT; protein kinase C theta type; nPKC-theta	WB	Human, Rat
	PKC theta Antibody (YA3162) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC theta.

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Cat. No.	Product Name		Classification

HY-143212

18:0-22:6 DG 1-Stearoyl-2-docosahexaenoyl-sn-glycerol		Phospholipids
18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol (DG) that can interact with RasGRP (Ras guanine nucleotide-releasing protein) (K_i = 8.37 μM) and modulate the activation of MAP kinases (such as ERK1/ERK2), which play a crucial role in cellular signaling processes. 18:0-22:6 DG can also activate protein kinase C (PKC) isozyme. 18:0-22:6 DG can be used for research of cancer, immunology and metabolic disease .

HY-148413

Aprinocarsen sodium 1 Publications Verification ISIS 3521 sodium		Antisense Oligonucleotides
Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers .

HY-174543

Human PRKCA mRNA		mRNA
Human PRKCA mRNA encodes the human protein kinase C alpha (PRKCA) protein, a member of Protein kinase C (PKC) family. PRKCA has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control.

HY-174542

Human PRKCB mRNA		mRNA
Human PRKCB mRNA encodes the human protein kinase C beta (PRKCB) protein, a member of Protein kinase C (PKC) family. PRKCB has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption.

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protein kinase C (PKC)

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