2. Search Result
Search Result
Results for "

synovial

" in MedChemExpress (MCE) Product Catalog:

66

Inhibitors & Agonists

1

Screening Libraries

2

Biochemical Assay Reagents

3

Peptides

7

Inhibitory Antibodies

19

Natural
Products

3

Recombinant Proteins

3

Isotope-Labeled Compounds

2

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1125
    Glucosamine
    10+ Cited Publications

    D-Glucosamine; Chitosamine

    		 CFTR Endogenous Metabolite Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Autophagy Inflammation/Immunology Cancer
    Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine
  • HY-N0262
    Cordycepin
    Maximum Cited Publications
    13 Publications Verification

    3'-Deoxyadenosine

    		 TNF Receptor MMP Bacterial Autophagy Antibiotic Infection Inflammation/Immunology Cancer
    Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .
    Cordycepin
  • HY-N0733
    Glucosamine hydrochloride
    10+ Cited Publications

    D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride

    		 Endogenous Metabolite Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Autophagy Inflammation/Immunology Cancer
    Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine hydrochloride
  • HY-135844
    LS-102
    5+ Cited Publications

    		 E1/E2/E3 Enzyme Inflammation/Immunology
    LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment .
    LS-102
  • HY-E70005I
    Collagenase, Type VI
    1 Publications Verification

    Type VI collagenase

    		 MMP Cancer
    Collagenase, Type VI (EC 3.4.24.3) is a collagenase that can degrade type VI collagen. Type VI collagen is a component of cell membranes in various tissues (such as skin, heart, blood vessels, cartilage, and synovial fluid). Excessive collagenase can cause extracellular matrix lesions. Collagenase is also a biomarker for tumor invasion and metastasis. Collagenase, Type VI can specifically act on the peptide bond between proline and glycine. This feature can be used to quickly and sensitively detect its concentration level in experiments using corresponding modified electrodes .
    Collagenase, Type VI
  • HY-120601
    Alizarin Red S sodium
    5+ Cited Publications

    ARS sodium

    		 Fluorescent Dye Others
    Alizarin Red S sodium is an anthraquinone derivative dye. When combined with cations such as calcium ions, the functional group of Alizarin Red S sodium can form a coordination bond with the cation through the oxygen atom to show orange-red fluorescence. Alizarin Red S sodium can be used for screening of calcium compounds in synovial fluid and detecting osteoblast differentiation, and can also be used for bone staining in mice. Excitation/emission wavelength: 500/570 nm .
    Alizarin Red S sodium
  • HY-B0808
    Oxaprozin

    Oxaprozinum; Wy21743

    		 COX NF-κB Akt IKK Apoptosis Inflammation/Immunology Cancer
    Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties .
    Oxaprozin
  • HY-145925B
    CFT8634
    1 Publications Verification

    		 PROTACs Epigenetic Reader Domain Cancer
    CFT8634 is an orally bioavailable PROTAC BRD9 targeted degrader based on the E3 ubiquitin ligase CRBN mechanism. CFT8634 can be used for the study of synovial sarcoma and SMARCB1-deficient solid tumors (Pink: BRD9 ligand (HY-169988); Blue: E3 ligase ligand (HY-169989); Black: linker (HY-169991). CFT8634 is a heterobifunctional molecule that binds to BRD9 at one end and recruits CRBN at the other end, which can inhibit the growth of tumor cells that depend on BRD9. CFT8634 can be used for the study of SMARCB1-related cancers (such as synovial sarcoma and malignant rhabdoid tumor) .
    CFT8634
  • HY-120601A
    Alizarin Red S
    5+ Cited Publications

    ARS

    		 Fluorescent Dye Others
    Alizarin Red S (ARS) is an anthraquinone derivative dye. When combined with cations such as calcium ions, the functional group of Alizarin Red S can form a coordination bond with the cation through the oxygen atom to show orange-red fluorescence. Alizarin Red S can be used for screening of calcium compounds in synovial fluid and detecting osteoblast differentiation, and can also be used for bone staining in mice. Excitation/emission wavelength: 500/570 nm .
    Alizarin Red S
  • HY-P99781
    Plozalizumab

    MLN-1202

    		 CCR Inflammation/Immunology Cancer
    Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
    Plozalizumab
  • HY-N0487
    Glucosamine sulfate
    10+ Cited Publications

    D-Glucosamine sulfate

    		 Endogenous Metabolite Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Autophagy Inflammation/Immunology Cancer
    Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine sulfate
  • HY-N0696
    Sipeimine
    4 Publications Verification

    Imperialine

    		 PI3K NF-κB Akt NOD-like Receptor (NLR) Pyroptosis Ferroptosis Inflammation/Immunology
    Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases .
    Sipeimine
  • HY-145645
    Paridiprubart

    NI-0101

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    Paridiprubart (NI-0101) is a humanised anti-TLR4 monoclonal antibody. Paridiprubar inhibits the production of pro-inflammatory cytokines by monocytes from rheumatoid arthritis specimen induced by rheumatoid arthritis synovial fluid (RASF). Paridiprubart can be used for the study of rheumatoid arthritis .
    Paridiprubart
  • HY-159579
    CW-3308

    		PROTACs Epigenetic Reader Domain Cancer
    CW-3308 is an orally active BRD9 PROTAC degrader with an DC50 of 92 nM. CW-3308 forms a ternary complex with BRD9 and cereblon to mediate BRD9 degradation. CW-3308 inhibits the viability of synovial sarcoma and rhabdoid tumor cells. CW-3308 reduces BRD9 protein levels in xenograft tumor tissues and suppresses tumor growth in xenograft models. CW-3308 can be used for the research of synovial sarcoma and rhabdoid tumors .
    CW-3308
  • HY-N2435
    [8]-Shogaol
    4 Publications Verification

    		 COX Apoptosis Cancer
    [8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC50=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC50=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC50=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA).
    [8]-Shogaol
  • HY-148739
    dBRD 9-A

    		PROTACs Epigenetic Reader Domain Apoptosis Cancer
    dBRD 9-A is a selective BRD9 PROTAC degrader. dBRD 9-A induces near complete BRD9 degradation dependent on E3 ubiquitin ligase CRBN and BRD9 bromodomain engagement, and drives loss of BRD9 chromatin binding genome-wide. dBRD 9-A downregulates oncogenic SS18-SSX-driven transcriptional programs, super enhancer-associated gene expression, and SS18-SSX1 super enhancer binding, and depletes GBAF complex members GLTSCR1/1L from SS18-SSX complexes. dBRD 9-A induces cell cycle arrest and increases apoptosis in synovial sarcoma cells. dBRD 9-A can be used for the research of synovial sarcoma .
    dBRD 9-A
  • HY-160822
    AGG-523

    PF-5212371

    		 ADAMTS MMP Inflammation/Immunology
    AGG-523 (PF-5212371) is an orally active, reversible, non-hydroxamate, zinc-binding selective inhibitor of ADAMTS4 and ADAMTS5 with IC50 of <0.03 and 0.04 μM. AGG-523 also inhibits MMP-2, -8, 12 activity AGG-523 attenuates release of aggrecanase-generated ARG-aggrecan fragments into synovial fluid, reduces surgery-induced ARG-aggrecan release in rat joint models, and inhibits aggrecanase activity to slow cartilage degradation. AGG-523 can be used for the research of osteoarthritis .
    AGG-523
  • HY-N0475
    Triptophenolide

    Hypolide; (+)-Triptophenolide

    		 Androgen Receptor Pyroptosis Caspase Bcl-2 Family Apoptosis Inflammation/Immunology Cancer
    Triptophenolide (Hypolide) is a colorless crystal isolated from the ethyl acetate extract of Tripterygium wilfordii. Triptophenolide is an orally active pan‑antagonist of the androgen receptor (AR) with an IC50 of 467 nM against human wild‑type AR. Triptophenolide reduces AR expression, inhibits AR nuclear translocation, downregulates prostate‑specific antigen mRNA levels, and suppresses the growth of AR‑positive prostate cancer cells. Triptophenolide shows anti-tumor effects against breast cancer by inhibiting cell proliferation and migration, inducing G1-phase arrest and apoptosis, repressing xenograft tumor growth. Triptophenolide inhibits pyroptosis, alleviates tissue inflammation, and ameliorates synovial injury. Triptophenolide can be used for the study of prostate cancer, rheumatoid arthritis and breast cancer .
    Triptophenolide
  • HY-139589
    Zaloglanstat

    ISC-27864; GRC-27864

    		 PGE synthase COX Collagen Neurological Disease Inflammation/Immunology
    Zaloglanstat (ISC-27864; GRC-27864) is a selective, orally active microsomal mPGES-1 inhibitor. Zaloglanstat has an IC50 of 5 nM for human mPGES-1 without significant inhibitory effect on COX-1/2 (IC50 >10 μM). Zaloglanstat blocks the conversion of arachidonic acid metabolite prostaglandin PGH2 to prostaglandin PGE2, thereby inhibiting inflammation-related PGE2 overproduction and reducing inflammatory responses and pain. Zaloglanstat inhibits IL-1β-induced PGE2 release in A549 cells and human synovial fibroblasts in vitro. Zaloglanstat inhibits PGE2 release in pig and dog whole blood with IC50s ??of 161 nM and 154 nM, respectively. Zaloglanstat can be used in the study of asthma, osteoarthritis, and neurodegenerative diseases .
    Zaloglanstat
  • HY-N0899
    Wilforine

    		JAK STAT Wnt β-catenin Inflammation/Immunology Cancer
    Wilforine is an orally active JAK-STAT pathway inhibitor with immunomodulatory effects and the ability to inhibit osteoclast fusion. Wilforine disrupts lipid raft integrity, reprograms cholesterol and glycosphingolipid metabolic pathways, regulates NF-κB and the complement system, and modulates the expression of various interleukins. Wilforine also inhibits the Wnt11/β-catenin signaling pathway and suppresses the proliferation of fibroblast-like synoviocytes. Wilforine can serve as a quality and pharmacokinetic marker for Tripterygium glycoside tablets, and can be applied to research on related diseases such as rheumatoid arthritis, inflammatory osteolysis, and SAPHO syndrome .
    Wilforine
  • HY-130622
    LT052
    1 Publications Verification

    		 Epigenetic Reader Domain Inflammation/Immunology
    LT052 is a highly selective BET BD1 inhibitor with an IC50 of 87.7 nM. LT052 exhibits nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD4 BD2 (IC50=12.130 μM). LT052 has anti-inflammatory?activity and can be used for acute gout arthritis research .
    LT052
  • HY-173447
    8-BuS-AMP

    		NTPDase CD73 Cancer
    8-BuS-AMP is a NTPDase1 inhibitor and a CD73/CD39 inhibitor, with an IC50 of 35 μM and a Ki value of 0.292 μM against human NTPDase1; its Ki values against human CD73 and CD39 are 1.19 μM and 0.847 μM, respectively. 8-BuS-AMP binds to the substrate-binding pockets of NTPDase1 and CD73 to effectively block the conversion of ATP and AMP to adenosine, thereby enhancing the activation and proliferation of human peripheral T lymphocytes. 8-BuS-AMP possesses excellent enzymatic hydrolysis resistance and metabolic stability, resists hydrolysis by multiple NTPDase subtypes, and shows no activity against P2Y1 and P2Y12 receptors. 8-BuS-AMP can be used in purinergic signaling pathway and cancer-related studies .
    8-BuS-AMP
  • HY-P99581
    Tabituximab barzuxetan (exclude Y90)

    OTSA101-DTPA; OTSA101-DTPA-90Y; OTSA101-SS01

    		 Radionuclide-Drug Conjugates (RDCs) Cancer
    Tabituximab barzuxetan (exclude Y90) (OTSA101-DTPA; OTSA101-DTPA-90Y; OTSA101-SS01) is a immunoconjugate composed of a humanized monoclonal antibody targeting FZD-10 (OTSA-101). Tabituximab barzuxetan exhibits anti-tumor activity. Tabituximab barzuxetan can be used for the research of synovial sarcoma .
    Tabituximab barzuxetan (exclude Y90)
  • HY-N8213
    Rapanone

    		Apoptosis Phospholipase Bacterial Parasite Infection Inflammation/Immunology Cancer
    Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM .
    Rapanone
  • HY-124958
    NDMC101

    		NF-κB Dipeptidyl Peptidase Metabolic Disease Inflammation/Immunology
    NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene expression. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al .
    NDMC101
  • HY-21075
    3-Furanoic acid

    		Endogenous Metabolite Inflammation/Immunology
    3-Furanoic acid is an active unit, and its derivatives have a wide range of anti-inflammatory activities. 3-Furanoic acid-related derivatives can target inflammation-related signaling pathways and inhibit the proliferation of synovial fibroblasts to exert immunomodulatory effects .
    3-Furanoic acid
  • HY-N0733R
    Glucosamine hydrochloride (Standard)

    D-(+)-Glucosamine hydrochloride (Standard); Chitosamine hydrochloride (Standard)

    		 Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Autophagy Inflammation/Immunology Cancer
    Glucosamine (hydrochloride) (Standard) is the analytical standard of Glucosamine (hydrochloride). This product is intended for research and analytical applications. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine hydrochloride (Standard)
  • HY-N0262R
    Cordycepin (Standard)

    3'-Deoxyadenosine (Standard)

    		 TNF Receptor Reference Standards MMP Bacterial Autophagy Antibiotic Infection Inflammation/Immunology Cancer
    Cordycepin (Standard) is the analytical standard of Cordycepin. This product is intended for research and analytical applications. Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .
    Cordycepin (Standard)
  • HY-167692
    JI069

    		STAT Others
    JI069 is a novel JAK-STAT inhibitor that demonstrates potent activity in suppressing Th1, Th2, and Th17 differentiation while promoting iTreg differentiation. JI069 effectively inhibits STAT3 activation as well as the activation of other STATs, including STAT1, STAT5, and STAT6. JI069 has shown significant therapeutic potential in alleviating symptoms of collagen-induced arthritis in mice while inhibiting cytokine production from T cells and the phosphorylation of STAT3 in synovial cells.
    JI069
  • HY-P4096
    HAP-1

    		Bacterial Inflammation/Immunology
    HAP-1 is a synovial-targeted transduction peptide. HAP-1 facilitates specific internalization of protein complexes into human and rabbit synovial cells. HAP-1 fused to an antimicrobial peptide, (KLAK)2, to generate a proapoptotic peptide DP2 .
    HAP-1
  • HY-101671
    S-methyl-KE-298

    M-2

    		 MMP Drug Metabolite Inflammation/Immunology
    S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
    S-methyl-KE-298
  • HY-178345
    ZZ7-23-022

    ZZ7

    		 Molecular Glues Epigenetic Reader Domain Cancer
    ZZ7-23-022 (ZZ7) is a selective BRD9 molecule glue degrader. ZZ7-23-022 effectively degrades BRD9 in synovial sarcoma cells, but does not affect cardiomyocytes. ZZ7-23-022 can be used for the research of cancer .
    ZZ7-23-022
  • HY-118725
    Luffariellolide

    		Phospholipase Inflammation/Immunology
    Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC50=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED50=50 μg/ear) .
    Luffariellolide
  • HY-139207
    Glucosamine sulfate potassium chloride

    		Endogenous Metabolite Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Autophagy Inflammation/Immunology Cancer
    Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate potassium chloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine sulfate potassium chloride
  • HY-106277A
    Fasitibant chloride hydrochloride

    MEN16132

    		 Bradykinin Receptor Metabolic Disease
    Fasitibant chloride hydrochloride (MEN16132) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B2 (BK2) receptor antagonist. Fasitibant chloride hydrochloride has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis .
    Fasitibant chloride hydrochloride
  • HY-117272A
    (2R,3R)-2,3,4-Trihydroxybutanoic acid

    		Endogenous Metabolite Others
    (2R,3R)-2,3,4-Trihydroxybutanoic acid, also known as erythronic acid, is a naturally occurring organic acid found in the aqueous humor of the eye, as well as in urine, plasma, cerebrospinal fluid, and synovial fluid, prevalent in both healthy adults and children; it is produced through the oxidation of GlcNAc.
    (2R,3R)-2,3,4-Trihydroxybutanoic acid
  • HY-N0487R
    Glucosamine sulfate (Standard)

    D-Glucosamine sulfate (Standard)

    		 Endogenous Metabolite Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Autophagy Reference Standards Inflammation/Immunology Cancer
    Glucosamine (sulfate) (Standard) is the analytical standard of Glucosamine (sulfate). This product is intended for research and analytical applications. Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine sulfate (Standard)
  • HY-N16372
    Pronqodine A

    		Indoleamine 2,3-Dioxygenase (IDO) Quinone Reductase Reactive Oxygen Species (ROS) Inflammation/Immunology
    Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation .
    Pronqodine A
  • HY-163512
    Anti-inflammatory agent 79

    		HIF/HIF Prolyl-Hydroxylase Inflammation/Immunology
    Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), which can effectively block HIF-1 signals and increase HIF- Degradation of 1α. Anti-inflammatory agent 79 inhibits synovial invasion and migration and inhibits angiogenesis. Anti-inflammatory agent 79 also effectively reduced foot swelling and arthritis in a mouse inflammation model, and down-regulated the levels of inflammatory factors and blood vessel proliferation in the body .
    Anti-inflammatory agent 79
  • HY-W590535
    19:0 PC

    1,2-DNPC; 1,2-Dinonadecanoyl-sn-glycero-3-phosphocholine

    		 Liposome Cancer
    19:0 PC is a saturated phospholipid that has been used as a standard for the quantification of phosphatidylcholines in human synovial fluid. It has also been used to study dynamics of lipid bilayer phase transition.
    19:0 PC
  • HY-139207A
    Glucosamine sulfate sodium chloride

    		Endogenous Metabolite Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Autophagy Inflammation/Immunology Cancer
    Glucosamine sulfate sodium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate sodium chloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine sulfate sodium chloride
  • HY-106277
    Fasitibant free base

    		Bradykinin Receptor Metabolic Disease
    Fasitibant (free base) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B2 (BK2) receptor antagonist. Fasitibant (free base) has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis .
    Fasitibant free base
  • HY-101671R
    S-methyl-KE-298 (Standard)

    M-2 (Standard)

    		 Reference Standards MMP Drug Metabolite Inflammation/Immunology
    S-methyl-KE-298 (Standard) is the analytical standard of S-methyl-KE-298. This product is intended for research and analytical applications. S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
    S-methyl-KE-298 (Standard)
  • HY-B0808S1
    Oxaprozin-d5

    Oxaprozinum-d5; Wy21743-d5

    		 Isotope-Labeled Compounds COX NF-κB Inflammation/Immunology Cancer
    Oxaprozin-d5 is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.
    Oxaprozin-d5
  • HY-B1125S
    Glucosamine-13C6

    D-Glucosamine-13C6; Chitosamine-13C6

    		 Isotope-Labeled Compounds CFTR HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Endogenous Metabolite Autophagy Inflammation/Immunology Cancer
    Glucosamine- 13C6 (D-Glucosamine- 13C6) is 13C labeled Glucosamine. Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine-13C6
  • HY-13478
    AS1940477

    		p38 MAPK TNF Receptor Interleukin Related Inflammation/Immunology
    AS1940477 (Compound 3f) is an orally active p38 MAPK inhibitor. AS1940477 inhibits the enzymatic activity of recombinant p38α and β isoforms. AS1940477 inhibits the production of pro-inflammatory cytokines (including TNFα, IL-1β, and IL-6) in human synovial interstitial cells and animal models of inflammation. AS1940477 can be used in research on inflammatory diseases .
    AS1940477
  • HY-162797
    PDE4-IN-18

    		Phosphodiesterase (PDE) TNF Receptor Interleukin Related Inflammation/Immunology
    PDE4-IN-18 (compound 1l) is a PDE4 inhibitor (IC50=1.55 μM) with anti-inflammatory activity. PDE4-IN-18 exerts anti-inflammatory effects by reducing excessive immune cell infiltration and intestinal membrane formation, as well as reducing the mRNA expression of pro-inflammatory cytokines (such as TNF-α and IL-6) in synovial tissue. PDE4-IN-18 can be used in the study of rheumatoid arthritis and psoriasis .
    PDE4-IN-18
  • HY-B0808A
    Oxaprozin potassium

    Oxaprozinum potassium; Wy21743 potassium

    		 COX NF-κB Akt IKK Apoptosis Inflammation/Immunology Cancer
    Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties .
    Oxaprozin potassium
  • HY-163533
    CPD-002

    		VEGFR Inflammation/Immunology
    CPD-002 is an inhibitor for vascular endothelial growth factor receptor 2 (VEGFR 2), that inhibits angiogenesis through inhibition of VEGFR2/PI3K/AKT signaling pathway. CPD-002 exhibits anti-inflammatory activity and attenuates rheumatoid arthritis .
    CPD-002
  • HY-B0808R
    Oxaprozin (Standard)

    Oxaprozinum (Standard); Wy21743 (Standard)

    		 Reference Standards COX NF-κB Akt IKK Apoptosis Inflammation/Immunology Cancer
    Oxaprozin (Standard) is the analytical standard of Oxaprozin. This product is intended for research and analytical applications. Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties .
    Oxaprozin (Standard)

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: