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Cat. No.: HY-124244

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DB-959

(Synonyms: PPARδ/γ agonist 1)

DB-959 (PPARδ/γ agonist 1) is a potent PPAR agonist targeting PPARδ/γ. DB-959 improves spatial learning and memory in mice induced by Streptozotocin (HY-13753) and has the potential to improve Alzheimer's disease (AD)..

For research use only. We do not sell to patients.

CAS No.: 1257641-15-8
Formula: C₂₅H₂₇NO₅
Molecular Weight:421.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DB-959 Chemical Structure

CAS No.: 1257641-15-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PPAR Isoforms :

In Vivo

PPARδ/γ agonist 1 (1 mg/kg; i.g.; daily, for 16 days; STZ-mediated Long Evans rats) restores STZ-mediated impairments of motor function^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

STZ-mediated Long Evans rats^[1]
Dosage:

1 mg/kg
Administration:

Oral gavage; daily, for 16 days
Result:

Improved performance in the STZ-mediated rats and had neuroprotective for both granule and Purkinje cells.

Chemical Information

CAS No. 1257641-15-8
Molecular Weight 421.49
Formula C₂₅H₂₇NO₅
SMILES

O=C(O)C[C@@H]1CCC2=C1C=CC(OCCC3=C(CC)OC(C4=CC=C(OC)C=C4)=N3)=C2
Synonyms

PPARδ/γ agonist 1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tong M, et, al. T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016;51(1):123-38. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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DB-959

All PPAR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DB-959 Related Classifications

HY-124244 Related Classifications