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Cat. No.: HY-183565

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HYF031

HYF031 is a selective, blood-brain barrier-permeable HDAC8 inhibitor with an IC₅₀ of 5.7 nM, and exhibits extremely low activity against most other HDAC subtypes. HYF031 is applicable for HDAC8 imaging studies.

For research use only. We do not sell to patients.

CAS No.: 1417997-91-1
Formula: C₁₆H₁₄BrNO₃
Molecular Weight:348.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HYF031 Chemical Structure

CAS No.: 1417997-91-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HDAC8

5.7 nM (IC₅₀)

All HDAC Isoforms :

In Vivo

[¹¹C]HYF031 (5.55-7.40 MBq; intravenous injection; single dose) exhibits detectable brain penetration, pharmacokinetic properties suitable for PET imaging, specific binding to HDAC8 in mouse brains, and is primarily metabolized via the hepatobiliary pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1417997-91-1
Molecular Weight 348.19
Formula C₁₆H₁₄BrNO₃
SMILES

COC1=CC=C(C(C2=CC=C(C=C2)Br)=C1)/C=C/C(NO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang Y, et al. The Development of the Novel Positron Emission Tomography Radiotracer for Selective HDAC8 Imaging. ACS Chem Neurosci. 2026;17(9):1802-1808. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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HYF031

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HYF031 Related Classifications

HY-183565 Related Classifications