2. Immunology/Inflammation
  3. COX
  4. Sphondin

Sphondin 

Cat. No.: HY-N2429 Purity: ≥99.0%
COA Handling Instructions

Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells.

For research use only. We do not sell to patients.

Sphondin Chemical Structure

Sphondin Chemical Structure

CAS No. : 483-66-9

Size Price Stock Quantity
1 mg USD 140 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 595 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].

IC50 & Target[1]

COX-2

 

In Vitro

Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE2 release[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

216.19

Appearance

Solid

Formula

C12H8O4
CAS No.
SMILES

O=C1C=CC2=C(C3=C(OC=C3)C(OC)=C2)O1
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (115.64 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6256 mL 23.1278 mL 46.2556 mL
5 mM 0.9251 mL 4.6256 mL 9.2511 mL
10 mM 0.4626 mL 2.3128 mL 4.6256 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥99.0%

COA (251 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Sphondin483-66-9COXCyclooxygenaseanti-inflammatoryairwayinflammationpulmonaryepithelialCOX-2PGE2A549Inhibitorinhibitorinhibit

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