1. Immunology/Inflammation
  2. COX
  3. Sphondin

Sphondin 

Cat. No.: HY-N2429
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Sphondin, isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells.

For research use only. We do not sell to patients.

Sphondin Chemical Structure

Sphondin Chemical Structure

CAS No. : 483-66-9

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Description

Sphondin, isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].

IC50 & Target[1]

COX-2

 

In Vitro

Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE2 release[1].

Molecular Weight

216.19

Formula

C₁₂H₈O₄

CAS No.

483-66-9

SMILES

O=C1C=CC2=C(C3=C(OC=C3)C(OC)=C2)O1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SphondinCOXCyclooxygenaseanti-inflammatoryairwayinflammationpulmonaryepithelialCOX-2PGE2A549Inhibitorinhibitorinhibit

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