TAK1-IN-5
TAK1-IN-5 (Compound 26) is an inhibitor of the transforming growth factor-β activated kinase (TAK1) with an IC50 value of 55 nM. TAK1-IN-5 can inhibit the growth of MPC-11 and H929 cells with a GI50 lower than 30 nM. TAK1-IN-5 can be used in the study of multiple myeloma .
For research use only. We do not sell to patients.
- Formula: C22H24N6O
- Molecular Weight:388.47
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All MAP3K Isoforms
More
Biological Activity
Description
IC50 & Target
IC50: 55 nM (TAK1)[1].
Chemical Information
-
Molecular Weight 388.47
-
Formula C22H24N6O
-
SMILES
CC1CN(CC(O1)C)C2=NN3C(C4=CC5=C(NN=C5C6CC6)C=C4)=CN=C3C=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)