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Cat. No.: HY-190795

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TAP-05

TAP-05 is a thiazole small molecule with inhibitory activity against parasites. TAP-05 inhibits the growth of Toxoplasma gondii and Leishmania infantum. TAP-05 can be used for research on toxoplasmosis and visceral leishmaniasis.

For research use only. We do not sell to patients.

CAS No.: 16085-74-8
Formula: C₁₅H₁₁N₅O₂S
Molecular Weight:325.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TAP-05 Chemical Structure

CAS No.: 16085-74-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Innate ImmunityParasitic InfectionOthers

Innate Immunity

TAP-05 (48 h) is cytotoxic to BALB/c peritoneal macrophages, with a CC₅₀ of 2.95 μM^[2].

Parasitic Infection

TAP-05 (72 h) inhibits intracellular tachyzoites of Toxoplasma gondii RH-2F1 in HFF cells, with an EC₅₀ of 0.264 μM and a selectivity index of 183.26^[1].
TAP-05 (0.264 μM; 48 h) induces cytoplasmic vacuolation, reduced ultrastructural signs of tachyzoite division, and occasional Golgi apparatus alterations in Toxoplasma gondii-infected HFF cells^[1].
TAP-05 (48 h) inhibits the growth of Leishmania infantum promastigotes with an IC₅₀ of 0.42 μM and a promastigote selectivity index of 7.07^[2].

Others

TAP-05 (72 h) exhibits low cytotoxicity against HFF cells, with a CC₅₀ of 48.44 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 16085-74-8
Molecular Weight 325.35
Formula C₁₅H₁₁N₅O₂S
SMILES

O=[N+](C1=CC(C2=CSC(N/N=C/C3=NC=CC=C3)=N2)=CC=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dias IO, et al. Highly Selective Thiazole Derivatives as Promising Anti-Toxoplasma gondii Agents. ACS Omega. 2026 Sep 24;11(39):59807-59814.

[2]. de Oliveira VVG, et al. Study of in vitro biological activity of thiazoles on Leishmania (Leishmania) infantum. Journal of global antimicrobial resistance. 2020 Sep;22:414-421.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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