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  3. TD-165

TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.

For research use only. We do not sell to patients.

TD-165 Chemical Structure

TD-165 Chemical Structure

CAS No. : 2305936-56-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 431 In-stock
Solution
10 mM * 1 mL in DMSO USD 431 In-stock
Solid
1 mg USD 150 In-stock
5 mg USD 300 In-stock
10 mg USD 450 In-stock
25 mg USD 900 In-stock
50 mg USD 1350 In-stock
100 mg USD 2000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].

IC50 & Target[1]

Cereblon

20.4 nM (DC50)

In Vitro

TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1].
TD-165 (0.1-10 μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK293T cells
Concentration: 0-100 nM
Incubation Time: 24 hours
Result: Exhibited an DC50 value of 20.4 nM.

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 24 hours
Result: Decreased the level of CRBN protein.
Molecular Weight

870.07

Formula

C46H59N7O8S

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (57.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1493 mL 5.7467 mL 11.4933 mL
5 mM 0.2299 mL 1.1493 mL 2.2987 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1493 mL 5.7467 mL 11.4933 mL 28.7333 mL
5 mM 0.2299 mL 1.1493 mL 2.2987 mL 5.7467 mL
10 mM 0.1149 mL 0.5747 mL 1.1493 mL 2.8733 mL
15 mM 0.0766 mL 0.3831 mL 0.7662 mL 1.9156 mL
20 mM 0.0575 mL 0.2873 mL 0.5747 mL 1.4367 mL
25 mM 0.0460 mL 0.2299 mL 0.4597 mL 1.1493 mL
30 mM 0.0383 mL 0.1916 mL 0.3831 mL 0.9578 mL
40 mM 0.0287 mL 0.1437 mL 0.2873 mL 0.7183 mL
50 mM 0.0230 mL 0.1149 mL 0.2299 mL 0.5747 mL
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TD-165 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TD-165
Cat. No.:
HY-130714
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