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TD-165 

Cat. No.: HY-130714 Purity: 98.01%
Handling Instructions

TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.

For research use only. We do not sell to patients.

TD-165 Chemical Structure

TD-165 Chemical Structure

CAS No. : 2305936-56-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 555 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 555 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].

IC50 & Target[1]

Cereblon

20.4 nM (DC50)

In Vitro

TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1].
TD-165 (0.1-10 μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK293T cells
Concentration: 0-100 nM
Incubation Time: 24 hours
Result: Exhibited an DC50 value of 20.4 nM.

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 24 hours
Result: Decreased the level of CRBN protein.
Molecular Weight

870.07

Formula

C46H59N7O8S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (57.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1493 mL 5.7467 mL 11.4933 mL
5 mM 0.2299 mL 1.1493 mL 2.2987 mL
10 mM 0.1149 mL 0.5747 mL 1.1493 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
TD-165
Cat. No.:
HY-130714
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