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TD-165 

Cat. No.: HY-130714
Handling Instructions

TD-165 is a cereblon (CRBN) degrader. TD-165comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.

For research use only. We do not sell to patients.

TD-165 Chemical Structure

TD-165 Chemical Structure

CAS No. : 2305936-56-3

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Description

TD-165 is a cereblon (CRBN) degrader. TD-165comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].

IC50 & Target

Cereblon

20.4 nM (DC50)

In Vitro

TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1].
TD-165 (0.1-10 μM; 24 hours) lead to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1].

Cell Viability Assay[1]

Cell Line: HEK293T cells
Concentration: 0-100 nM
Incubation Time: 24 hours
Result: Exhibited an DC50 value of 20.4 nM.

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 24 hours
Result: Decreased the level of CRBN protein.
Molecular Weight

870.07

Formula

C₄₆H₅₉N₇O₈S

CAS No.

2305936-56-3

SMILES

O=C([[email protected]]1N(C([[email protected]@H](NC(CCCCCCCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[[email protected]](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TD-165TD165TD 165PROTACProteolysis-targeting chimeraCRBNdegraderInhibitorinhibitorinhibit

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