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Cat. No.: HY-159597

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Thalidomide-methylpyrrolidine

Thalidomide-methylpyrrolidine is a ligand for E3 ubiquitinase. Thalidomide-methylpyrrolidine can be used to synthesize CW-3308 (HY-159579).

For research use only. We do not sell to patients.

CAS No.: 2616540-84-0
Formula: C₁₆H₁₅N₃O₄
Molecular Weight:313.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Thalidomide-methylpyrrolidine Chemical Structure

CAS No.: 2616540-84-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Thalidomide-methylpyrrolidine is a ligand for E3 ubiquitinase. Thalidomide-methylpyrrolidine can be used to synthesize CW-3308 (HY-159579)^[1].

IC₅₀ & Target

Cereblon

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 2616540-84-0
Molecular Weight 313.31
Formula C₁₆H₁₅N₃O₄
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C4C(CN(C)C4)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang C, et al. Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9. J Med Chem. 2024 Aug 22;67(16):14125-14154. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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