Triptohypol E

Cat. No.: HY-N17528: Data Sheet Handling Instructions
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Triptohypol E is a triterpenoid compound and nitric oxide production inhibitor that can be isolated from the leaves of Rhododendron dauricum L. Triptohypol E inhibits nitric oxide production in LPS-stimulated macrophages in a dose-dependent manner.

For research use only. We do not sell to patients.

Triptohypol E Chemical Structure

CAS No. : 268541-25-9

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•Related Small Molecules:

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
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Description

In Vitro

Triptohypol E (30 μM; 24 h) exhibits no cytotoxicity toward RAW 264.7 cells^[1].
Triptohypol E (3-30 μM; 2 h pre-incubation followed by 24 h LPS co-incubation) dose-dependently inhibits NO production in LPS-stimulated RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	RAW 264.7
Concentration:	30 μM
Incubation Time:	24 h
Result:	Showed no cytotoxicity toward RAW 264.7 cells.

Molecular Weight

456.74

Formula

C₃₁H₅₂O₂

CAS No.

268541-25-9

SMILES

C[C@]12[C@@]([C@@H](C=C3[C@]2(CC[C@@]4([C@@]3([H])[C@H]([C@@H](CC4)C)C)C)C)OC)([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC1)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang J, et al. A new pentacyclic triterpenoid from the leaves of Rhododendron dauricum L. with inhibition of NO production in LPS-induced RAW 264.7 cells. Nat Prod Res. 2020 Dec;34(23):3313-3319. [Content Brief]

Triptohypol E Related Classifications

Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triptohypol E268541-25-9NO SynthaseNitric oxide synthasesNOSmacrophagesnitric oxide production inhibitorRAW 264.7 cellsRhododendron dauricum L.LPSInhibitorinhibitorinhibit

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