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Cat. No.: HY-N15336

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Tschimganin

Tschimganin is an orally active monoterpene benzoate natural product with antibacterial and other activities. Tschimganin reverses the drug resistance of Staphylococcus aureus and exerts antibacterial, membrane-disrupting, biofilm-inhibiting, and anti-inflammatory effects. Tschimganin acts as an Estrogen Receptor agonist, increases uterine mass and water content and affects ovarian mass in juvenile rats. Tschimganin is useful for research on bacterial infections and also serves as an intermediate for research on organic synthesis.

For research use only. We do not sell to patients.

CAS No.: 38970-49-9
Formula: C₁₈H₂₄O₄
Molecular Weight:304.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (295 KB)

Tschimganin Chemical Structure

CAS No.: 38970-49-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Estrogen Receptor/ERR Isoforms :

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Tschimganin (compound 3) exhibits activity against Staphylococcus aureus 209, producing a 23 mm inhibition zone at 400 μg/cup, shows no inhibitory activity against Candida albicans and Escherichia coli, and has almost no DPPH radical scavenging activity^[5].

Others

Tschimganin can serve as a lead scaffold for the synthesis of a series of derivatives, and the resulting analogs possess insecticidal and antibacterial activities^[1].
Tschimganin can serve as a lead compound for the design and synthesis of a series of novel terpene ester derivatives containing a bicyclo[2.2.1]heptane structure, and most analogues exhibit moderate to excellent insecticidal activity against Aphis gossypii^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tschimganin (compound 26) (1 mg/kg; p.o.; once daily; 3 days) exhibits estrogen activity in immature female rats by increasing uterus growth and increasing ovary growth relative to control^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 38970-49-9
Molecular Weight 304.38
Formula C₁₈H₂₄O₄
SMILES

C[C@](C1(C)C)(CC[C@]1([H])C2)[C@H]2OC(C(C=C3)=CC(OC)=C3O)=O
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (295 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou Y, et al. Synthesis, Insecticidal, Fungicidal Activities and Structure⁻Activity Relationships of Tschimganin Analogs. Molecules (Basel, Switzerland). 2018 Jun 18;23(6):1473.

[2]. Nazrullaev SS, et al. Estrogen activity of terpenoids from plants of the genus Ferula. Chemistry of natural compounds. 2008 Sep;44(5):572-7.

[3]. Liu C, et al. Design, synthesis, and insecticidal activity of novel terpenoid ester compounds containing bicyclo [2.2. 1] heptane against Aphis gossypii Glover. Advanced Agrochem. 2024 Jun 1;3(2):171-81.

[4]. Alqahtani OS, et al. Integrated Phytochemical Exploration Studies and Computational Biology Approaches of Aloe Vera (L.) Burm. f., Flowers Coupled with Human ACE. Journal of Pharmaceutical Innovation. 2026 Apr;21(2):119.

[5]. Trusheva B, et al. Antibacterial mono- and sesquiterpene esters of benzoic acids from Iranian propolis. Chemistry Central journal. 2010 Mar 29;4:8.

Calculators

Molarity Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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