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Cat. No.: HY-188402

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UNC1215-COOH

UNC1215-COOH is a Ligands for E3 Ligase. UNC1215-COOH binds to the L3MBTL3-DCAF5 E3 ligase complex. UNC1215-COOH can be used to synthesize dnAurA-A10 (HY-188401).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1418022-41-9
화학식: C₃₃H₄₃N₅O₄
분자량:573.73

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

UNC1215-COOH Chemical Structure

CAS No.: 1418022-41-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

UNC1215-COOH is a Ligands for E3 Ligase. UNC1215-COOH binds to the L3MBTL3-DCAF5 E3 ligase complex. UNC1215-COOH can be used to synthesize dnAurA-A10 (HY-188401)^[1].

IC₅₀ & Target

^[1]

DCAF5

All Ligands for E3 Ligase Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1418022-41-9
분자량 573.73
화학식 C₃₃H₄₃N₅O₄
SMILES

O=C(O)C1=CC=C(NC2=CC(C(N3CCC(N4CCCC4)CC3)=O)=CC=C2C(N5CCC(N6CCCC6)CC5)=O)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Qian B, et al. A nuclear-targeted PROTAC enables subcellular-selective degradation of AURKA. Biochemical and biophysical research communications. 2026 Oct 08;834:154458.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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수량:
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UNC1215-COOH

All Ligands for E3 Ligase Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

UNC1215-COOH Related Classifications

HY-188402 Related Classifications

Bioz

Keywords

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