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Cat. No.: HY-190849

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uPA-IN-1

uPA-IN-1 is a uPA inhibitor (IC₅₀ = 0.546 μM). uPA-IN-1 induces G2/M cell cycle arrest, Apoptosis, and an increase in intracellular ROS, while upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-2. uPA-IN-1 can be used for cancer research.

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CAS No.: 2866142-33-6
화학식: C₁₉H₁₆N₂O₅
분자량:352.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

uPA-IN-1 Chemical Structure

CAS No.: 2866142-33-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

IC₅₀ & Target

^[1]

Bax

Bcl-2

All Bcl-2 Family Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
WI-38	IC50	44.43 μM	Cytotoxicity against human WI38 normal lung fibroblasts assessed as viability reduction by MTT assay with absorbance measured at 570 nm. Cytotoxicity against human WI38 normal lung fibroblasts assessed as viability reduction by MTT assay with absorbance measured at 570 nm.	42826661
MDA-MB-231	IC50	2.64 μM	Cytotoxicity against human MDA-MB-231 cells assessed as viability reduction by MTT assay with absorbance measured at 570 nm. Cytotoxicity against human MDA-MB-231 cells assessed as viability reduction by MTT assay with absorbance measured at 570 nm.	42826661
MCF7	IC50	4.89 μM	Cytotoxicity against human MCF-7 cells assessed as viability reduction by MTT assay with absorbance measured at 570 nm. Cytotoxicity against human MCF-7 cells assessed as viability reduction by MTT assay with absorbance measured at 570 nm.	42826661
HeLa	IC50	9.53 μM	Cytotoxicity against human HeLa cells assessed as viability reduction by MTT assay with absorbance measured at 570 nm. Cytotoxicity against human HeLa cells assessed as viability reduction by MTT assay with absorbance measured at 570 nm.	42826661
HepG2	IC50	5.93 μM	Cytotoxicity against human HepG-2 cells assessed as viability reduction by MTT assay with absorbance measured at 570 nm. Cytotoxicity against human HepG-2 cells assessed as viability reduction by MTT assay with absorbance measured at 570 nm.	42826661

In Vitro

Anti-cancerApoptosisCell Cycle RegulationOxidative StressOthers

Anti-cancer

uPA-IN-1 exhibits cytotoxicity against MDA-MB-231, MCF-7, HeLa, and HepG-2 cells, with the lowest IC₅₀ of 2.64 μM in MDA-MB-231 and an IC₅₀ of 44.43 μM in WI38 normal lung fibroblasts^[1].

Apoptosis

uPA-IN-1 (24 h) induces apoptosis in MCF-7 cells, with a total apoptosis rate of 31.41% and a necrosis rate as low as 3.81%^[1].

Cell Cycle Regulation

uPA-IN-1 (24 h) arrests MCF-7 cells at the G2/M phase, increasing the G2/M phase cell population to 37.04% and decreasing the G0-G1 phase to 49.24%^[1].

Oxidative Stress

uPA-IN-1 (24 h) increases intracellular ROS in MCF-7 cells by 3.105-fold relative to the untreated control^[1].

Others

uPA-IN-1 (Compound 13) inhibits uPA with an IC₅₀ of 0.546 μM in a cell-free fluorescence assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

IC₅₀ (4.89 μM)
Incubation Time:

24 h
Result:

Produced G0-G1 = 49.24%, S = 13.72%, and G2/M = 37.04%.

Related Protocols :

Chemical Information

CAS No. 2866142-33-6
분자량 352.34
화학식 C₁₉H₁₆N₂O₅
SMILES

O=C(O)[C@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(OCO4)C4=C3)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Sheha TA, et al. Design, synthesis and anticancer potential of new peptide conjugates via urokinase inhibition: biological and in silico studies. Bioorganic chemistry. 2026 Oct 01;183:110602. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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