Cyclic AMP sodium
Based on 30 publication(s) in Google Scholar
Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 37839-81-9
- Formula: C10H11N5NaO6P
- Molecular Weight:351.19
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cyclic AMP sodium
More- Immunity. 2025 Mar 21:S1074-7613(25)00093-7. [Abstract]
- Cell Stem Cell. 2026 May 15:S1934-5909(26)00158-X. [Abstract]
- Cell Host Microbe. 2026 Mar 11;34(3):494-508.e7. [Abstract]
- Nat Neurosci. 2022 Jun;25(6):805-817. [Abstract]
- Nat Protoc. 2023 Jun;18(6):1930-1957. [Abstract]
- Adv Sci (Weinh). 2025 May 14:e2500566. [Abstract]
- Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
- Biomaterials. 2025 Mar:314:122873. [Abstract]
- Cancer Lett. 2025 Sep 29:634:218069. [Abstract]
- Mater Today Bio. 2026 Mar 3:37:102985. [Abstract]
- Dev Cell. 2025 Sep 3:S1534-5807(25)00530-1. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- Talanta. 2024 Jan 15:267:125171. [Abstract]
- J Environ Sci. 2026 Jun 25.
- Cells. 2024 Nov 2;13(21):1811. [Abstract]
- Chem Biol Interact. 2026 Jul 25:435:112138. [Abstract]
- Exp Neurol. 2026 Jun 26:115897. [Abstract]
- FEBS J. 2026 Mar 10. [Abstract]
- Genes Immun. 2026 Mar 10. [Abstract]
- PLoS Genet. 2026 Jan 23;22(1):e1012013. [Abstract]
- Endocrinology. 2023 Feb 11;164(4):bqad035. [Abstract]
- Arch Biochem Biophys. 2025 Oct:772:110552. [Abstract]
- J Reprod Immunol. 2022 Jun;151:103623. [Abstract]
- Fitoterapia. 2026 Apr:190:107182. [Abstract]
- J Assist Reprod Genet. 2025 Feb;42(2):665-678. [Abstract]
- STAR Protoc. 2026 Mar 20;7(1):104353. [Abstract]
- bioRxiv. 2026 Jan 2:2025.12.31.696910. [Abstract]
- bioRxiv. 2025 Sep 29.
- bioRxiv. 2024 July 27.
- Methods Mol Biol. 2023:2683:103-111. [Abstract]
Customer Validation & Images
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RT-PCR
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WB
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RT-PCR
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Cell Imaging/Staining
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ELISA
Biological Activity
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Human Endogenous Metabolite |
Microbial Metabolite |
Cyclic AMP (Cyclic adenosine monophosphate) sodium modulates mediator generation. Cyclic AMP sodium suppresses the expression of pro-inflammatory cytokines, including TNF-α and IL-12, and enhances the production of the anti-inflammatory cytokine IL-10.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 37839-81-9
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Appearance Solid
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Molecular Weight 351.19
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Formula C10H11N5NaO6P
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Color White to off-white
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP4(O[Na])=O)[C@@H](CO4)O3
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Synonyms
Cyclic adenosine monophosphate sodium; Adenosine cyclic 3', 5'-monophosphate sodium; cAMP sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (30)
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Journal Impact Factor
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Most Recent
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Immunity
The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2. [Abstract]2025 Mar 21:S1074-7613(25)00093-7. PMID: 40139186 -
Cell Stem Cell
Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems. [Abstract]2026 May 15:S1934-5909(26)00158-X. PMID: 42143017 -
Cell Host Microbe
2026 Mar 11;34(3):494-508.e7. PMID: 41747724 -
Nat Neurosci
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations. [Abstract]2022 Jun;25(6):805-817. PMID: 35637371 -
Nat Protoc
Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures. [Abstract]2023 Jun;18(6):1930-1957. PMID: 37045994 -
Adv Sci (Weinh)
2025 May 14:e2500566. PMID: 40365742 -
Adv Sci (Weinh)
Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]2024 Sep 4:e2402393. PMID: 39229959
Cyclic AMP sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
After treating KGN cells with 20 μM of cAMP for 24 h, the expression level of KITL significantly increased.
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Biomaterials
LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway. [Abstract]2025 Mar:314:122873. PMID: 39369670 -
Cancer Lett
2025 Sep 29:634:218069. PMID: 41033606 -
Mater Today Bio
Age-mimicking hydrogel stiffness recapitulates the mechanical niche of the hippocampus to regulate neural stem cell senescence. [Abstract]2026 Mar 3:37:102985. PMID: 41852885 -
Dev Cell
A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma. [Abstract]2025 Sep 3:S1534-5807(25)00530-1. PMID: 40930100 -
Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
Talanta
A simple, rapid and sensitive HILIC LC-MS/MS method for simultaneous determination of 16 purine metabolites in plasma and urine. [Abstract]2024 Jan 15:267:125171. PMID: 37696233 -
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Cells
Proof-of-Concept for Long-Term Human Endometrial Epithelial Organoids in Modeling Menstrual Cycle Responses. [Abstract]2024 Nov 2;13(21):1811. PMID: 39513919
Cyclic AMP sodium purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811. [Abstract]
Cyclic AMP (0.5 mM; 14 days) treatment following estrogen (E2) treatment from day 14 onwards in hEOs was measured by quantitative polymerase chain reaction (qPCR).
Cyclic AMP sodium purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811. [Abstract]
Cyclic AMP (0.5 mM; 14 days). Representative immunofluorescent images showing ESR1 (ER), PGR (PR), and PAEP expression at day 21 and 28 through 28-day treatment in hEOs were obtained.
Cyclic AMP sodium purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811. [Abstract]
Cyclic AMP (0.5 mM; 14 days). Violin plot of ELISA for secreted PAEP (left) and SPP1 (right) from culture supernatant with different hormone treatments at day 21 in hEOs was shown.
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Chem Biol Interact
Autophagy attenuates the secondary senescence of endometrial stromal cells induced by Bisphenol S. [Abstract]2026 Jul 25:435:112138. PMID: 42114668 -
Exp Neurol
Roles of astrocytic Connexin 43 gap junctional deficit in alpha-synucleinopathy and inflammation relevant to Parkinson's. [Abstract]2026 Jun 26:115897. PMID: 42362037 -
FEBS J
2026 Mar 10. PMID: 41804674 -
Genes Immun
MTA1-mediated transcriptional repression of Cox2 confers resistance against neutrophil infiltration in endometritis. [Abstract]2026 Mar 10. PMID: 41807815 -
PLoS Genet
A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype. [Abstract]2026 Jan 23;22(1):e1012013. PMID: 41575937 -
Endocrinology
2023 Feb 11;164(4):bqad035. PMID: 36825874 -
Arch Biochem Biophys
TET3 inhibits the decidualization of human endometrial stromal cells by regulating ITGA10 transcription through recruiting HDAC1/2. [Abstract]2025 Oct:772:110552. PMID: 40675525 -
J Reprod Immunol
2022 Jun;151:103623. PMID: 35430461 -
Fitoterapia
The stem-derived bioactive fraction of Syringa oblata Lindl. Ameliorates insomnia via cAMP signaling-mediated regulation of neurotransmission, oxidative stress, and inflammation: A multi-omics study. [Abstract]2026 Apr:190:107182. PMID: 41861857 -
J Assist Reprod Genet
FXYD1 was identified as a hub gene in recurrent miscarriage and involved in decidualization via regulating Na/K-ATPase activity. [Abstract]2025 Feb;42(2):665-678. PMID: 39730944
Cyclic AMP sodium purchased from MedChemExpress. Usage Cited in: J Assist Reprod Genet. 2025 Feb;42(2):665-678. [Abstract]
Cyclic AMP (0.5 mM; 4 days). The FOXO1 mRNA expression in T-HESCs transfected with either control vector or FXYD1-overexpression plasmids at 0, 2, and 4 days during decidualization was measured.
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STAR Protoc
Protocol to identify the signaling network of nucleotide second messengers in Shigella sonnei. [Abstract]2026 Mar 20;7(1):104353. PMID: 41671092 -
bioRxiv
2026 Jan 2:2025.12.31.696910. PMID: 41509464 -
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Methods Mol Biol
Characterizing the Neuron-Glial Interactions by the Co-cultures of Human iPSC-Derived Oligodendroglia and Neurons. [Abstract]2023:2683:103-111. PMID: 37300770
Solvent & Solubility
DMSO : 50 mg/mL (142.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.12 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.12 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. G M Fimia, et al. Cyclic AMP signaling. J Cell Sci. 2001 Jun;114(Pt 11):1971-2. [Content Brief]
[2]. Paolo Sassone-Corsi, et al. The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a011148. [Content Brief]
[3]. Aronoff DM, et, al. Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res. 2006 Nov;26(11):827-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.8475 mL | 14.2373 mL | 28.4746 mL | 71.1865 mL |
| 5 mM | 0.5695 mL | 2.8475 mL | 5.6949 mL | 14.2373 mL | |
| 10 mM | 0.2847 mL | 1.4237 mL | 2.8475 mL | 7.1187 mL | |
| 15 mM | 0.1898 mL | 0.9492 mL | 1.8983 mL | 4.7458 mL | |
| 20 mM | 0.1424 mL | 0.7119 mL | 1.4237 mL | 3.5593 mL | |
| 25 mM | 0.1139 mL | 0.5695 mL | 1.1390 mL | 2.8475 mL | |
| 30 mM | 0.0949 mL | 0.4746 mL | 0.9492 mL | 2.3729 mL | |
| 40 mM | 0.0712 mL | 0.3559 mL | 0.7119 mL | 1.7797 mL | |
| 50 mM | 0.0569 mL | 0.2847 mL | 0.5695 mL | 1.4237 mL | |
| 60 mM | 0.0475 mL | 0.2373 mL | 0.4746 mL | 1.1864 mL | |
| 80 mM | 0.0356 mL | 0.1780 mL | 0.3559 mL | 0.8898 mL | |
| 100 mM | 0.0285 mL | 0.1424 mL | 0.2847 mL | 0.7119 mL |
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