DEL-C1
DEL-C1 is a CHI3L1 inhibitor. DEL-C1 can restore the ability to clear Amyloid-β and repair lysosomal function of astrocytes. DEL-C1 can inhibit NF-κB signaling and IL-6 secretion. DEL-C1 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C38H45N7O4S
- Molecular Weight:695.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DEL-C1 (5-25 μM, 30 mins) restores the CHI3L1-induced decrease in Aβ1-42 uptake in human iPSC-derived astrocytes[1].
DEL-C1 (5-25 μM, 30 mins) improves the CHI3L1-inhibited lysosomal degradation of DQ-BSA in the astrocytes[1].
DEL-C1 (5-25 μM, 30 mins) inhibits CHI3L1-driven secretion of CHI3L1 and IL-6 and activation of NF-κB in the astrocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 695.87
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Formula C38H45N7O4S
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SMILES
CNC(C[C@H](C1=CC=CC=C1)NC(C[C@@H](NC([C@@H]2CCCC[C@H]2NCC3=CN=C(O3)C4=C(N=C(S4)C)C)=O)CC5=CNC6=C5C=CC=C6)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DEL-C1 Related Classifications
HY-179214 Related Classifications
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