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Cat. No.: HY-150812

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VHL Ligand 23

VHL Ligand 23 is a VHL ligand with a IC₅₀ value of 26.8 nM. VHL Ligand 23 can be used in the research of prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 2308497-42-7
Formula: C₂₈H₃₅N₅O₅S
Molecular Weight:553.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VHL Ligand 23 Chemical Structure

CAS No.: 2308497-42-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

VHL Ligand 23 is a VHL ligand with a IC₅₀ value of 26.8 nM. VHL Ligand 23 can be used in the research of prostate cancer^[1].

IC₅₀ & Target^[1]

VHL

26.8 nM (IC₅₀)

All Ligands for E3 Ligase Isoforms :

In Vitro

VHL Ligand 23 binds to purified VHL protein with high affinity, exhibiting an IC₅₀ of 26.8 nM^[1].
VHL Ligand 23 competitively blocks ARD-69-induced AR degradation in LNCaP and VCaP cells, verifying the PROTAC's dependence on VHL binding activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2308497-42-7
Molecular Weight 553.67
Formula C₂₈H₃₅N₅O₅S
SMILES

CNC(C[C@@H](C1=CC=C(C=C1)C2=C(N=CS2)C)NC([C@@H]3C[C@H](CN3C([C@H](C(C)C)C4=CC(C)=NO4)=O)O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. Journal of medicinal chemistry. 2019 Jan 24;62(2):941-964. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VHL Ligand 23

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VHL Ligand 23 Related Classifications

HY-150812 Related Classifications