VHL Ligand 23
VHL Ligand 23 is a VHL ligand with a IC50 value of 26.8 nM. VHL Ligand 23 can be used in the research of prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 2308497-42-7
- Formula: C28H35N5O5S
- Molecular Weight:553.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
VHL 26.8 nM (IC50) |
In Vitro
VHL Ligand 23 binds to purified VHL protein with high affinity, exhibiting an IC50 of 26.8 nM[1].
VHL Ligand 23 competitively blocks ARD-69-induced AR degradation in LNCaP and VCaP cells, verifying the PROTAC's dependence on VHL binding activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2308497-42-7
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Molecular Weight 553.67
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Formula C28H35N5O5S
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SMILES
CNC(C[C@@H](C1=CC=C(C=C1)C2=C(N=CS2)C)NC([C@@H]3C[C@H](CN3C([C@H](C(C)C)C4=CC(C)=NO4)=O)O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VHL Ligand 23 Related Classifications
HY-150812 Related Classifications
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