VHL Ligand 23
VHL Ligand 23 is a VHL ligand with a IC50 value of 26.8 nM. VHL Ligand 23 can be used in the research of prostate cancer.
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- CAS No.: 2308497-42-7
- Formule: C28H35N5O5S
- Masse moléculaire:553.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
VHL 26.8 nM (IC50) |
In Vitro
VHL Ligand 23 binds to purified VHL protein with high affinity, exhibiting an IC50 of 26.8 nM[1].
VHL Ligand 23 competitively blocks ARD-69-induced AR degradation in LNCaP and VCaP cells, verifying the PROTAC's dependence on VHL binding activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2308497-42-7
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Masse moléculaire 553.67
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Formule C28H35N5O5S
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SMILES
CNC(C[C@@H](C1=CC=C(C=C1)C2=C(N=CS2)C)NC([C@@H]3C[C@H](CN3C([C@H](C(C)C)C4=CC(C)=NO4)=O)O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VHL Ligand 23 Related Classifications
HY-150812 Related Classifications
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