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Art. -Nr.: HY-150812

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VHL Ligand 23

VHL Ligand 23 is a VHL ligand with a IC₅₀ value of 26.8 nM. VHL Ligand 23 can be used in the research of prostate cancer.

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CAS. Nr.: 2308497-42-7
Formel: C₂₈H₃₅N₅O₅S
Molecular Weight:553.67

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

VHL Ligand 23 Chemical Structure

CAS. Nr.: 2308497-42-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

VHL Ligand 23 is a VHL ligand with a IC₅₀ value of 26.8 nM. VHL Ligand 23 can be used in the research of prostate cancer^[1].

IC₅₀ & Target^[1]

VHL

26.8 nM (IC₅₀)

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen :

In Vitro

VHL Ligand 23 binds to purified VHL protein with high affinity, exhibiting an IC₅₀ of 26.8 nM^[1].
VHL Ligand 23 competitively blocks ARD-69-induced AR degradation in LNCaP and VCaP cells, verifying the PROTAC's dependence on VHL binding activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2308497-42-7
Molecular Weight 553.67
Formel C₂₈H₃₅N₅O₅S
SMILES

CNC(C[C@@H](C1=CC=C(C=C1)C2=C(N=CS2)C)NC([C@@H]3C[C@H](CN3C([C@H](C(C)C)C4=CC(C)=NO4)=O)O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. Journal of medicinal chemistry. 2019 Jan 24;62(2):941-964. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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VHL Ligand 23

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

VHL Ligand 23 Related Classifications

HY-150812 Related Classifications