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Cat. No.: HY-149201

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VISTA-IN-1

VISTA-IN-1 is an orally active VISTA inhibitor. VISTA-IN-1 inhibits the function of VISTA and promotes the secretion of IL-2. VISTA-IN-1 exerts inhibitory effects on mouse melanoma in vivo. VISTA-IN-1 is applicable to melanoma-related research.

For research use only. We do not sell to patients.

CAS No.: 669749-25-1
Formula: C₁₈H₁₇N₇OS₂
Molecular Weight:411.50

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Please store the product under the recommended conditions in the Certificate of Analysis.

VISTA-IN-1 Chemical Structure

CAS No.: 669749-25-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

All Interleukin Related Isoforms :

In Vitro

VISTA-IN-1 (Compound 6809-0223) (10 μg/mL; 2 h) exhibits strong affinity for mouse VISTA-Fc fusion protein in a competitive ELISA assay, with a binding rate of 16.02%^[1].
VISTA-IN-1 (20 μM; 48 h) inhibits the immunosuppressive effect of mouse VISTA-Fc fusion protein and promotes IL-2 secretion by CD-3-activated mouse primary T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VISTA-IN-1 (Compound 6809-0223) (20 mg/kg; p.o.; daily; from day 3 post-inoculation until study termination) demonstrates in vivo tumor inhibitory activity in a mouse B16-F10 melanoma model, with an average tumor volume of 2.43 cm³^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 669749-25-1
Molecular Weight 411.50
Formula C₁₈H₁₇N₇OS₂
SMILES

O=C1N=C(NC=2N=C3C=CC(=CC3=C(N2)C)C)NC(=C1)CSC4=NN=C(S4)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu J, et al. There is the micromolecular compound and application thereof of affinity with VISTA. CN108743590A, 2019-02-02.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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VISTA-IN-1

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VISTA-IN-1 Related Classifications

HY-149201 Related Classifications