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Cat. No.: HY-149201

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VISTA-IN-1

VISTA-IN-1 is an orally active VISTA inhibitor. VISTA-IN-1 inhibits the function of VISTA and promotes the secretion of IL-2. VISTA-IN-1 exerts inhibitory effects on mouse melanoma in vivo. VISTA-IN-1 is applicable to melanoma-related research.

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CAS No.: 669749-25-1
화학식: C₁₈H₁₇N₇OS₂
분자량:411.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

VISTA-IN-1 Chemical Structure

CAS No.: 669749-25-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Interleukin Related Isoforms :

In Vitro

VISTA-IN-1 (Compound 6809-0223) (10 μg/mL; 2 h) exhibits strong affinity for mouse VISTA-Fc fusion protein in a competitive ELISA assay, with a binding rate of 16.02%^[1].
VISTA-IN-1 (20 μM; 48 h) inhibits the immunosuppressive effect of mouse VISTA-Fc fusion protein and promotes IL-2 secretion by CD-3-activated mouse primary T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VISTA-IN-1 (Compound 6809-0223) (20 mg/kg; p.o.; daily; from day 3 post-inoculation until study termination) demonstrates in vivo tumor inhibitory activity in a mouse B16-F10 melanoma model, with an average tumor volume of 2.43 cm³^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 669749-25-1
분자량 411.50
화학식 C₁₈H₁₇N₇OS₂
SMILES

O=C1N=C(NC=2N=C3C=CC(=CC3=C(N2)C)C)NC(=C1)CSC4=NN=C(S4)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Liu J, et al. There is the micromolecular compound and application thereof of affinity with VISTA. CN108743590A, 2019-02-02.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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