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Art. -Nr.: HY-149201

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VISTA-IN-1

VISTA-IN-1 is an orally active VISTA inhibitor. VISTA-IN-1 inhibits the function of VISTA and promotes the secretion of IL-2. VISTA-IN-1 exerts inhibitory effects on mouse melanoma in vivo. VISTA-IN-1 is applicable to melanoma-related research.

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CAS. Nr.: 669749-25-1
Formel: C₁₈H₁₇N₇OS₂
Molecular Weight:411.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

VISTA-IN-1 Chemical Structure

CAS. Nr.: 669749-25-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

VISTA-IN-1 (Compound 6809-0223) (10 μg/mL; 2 h) exhibits strong affinity for mouse VISTA-Fc fusion protein in a competitive ELISA assay, with a binding rate of 16.02%^[1].
VISTA-IN-1 (20 μM; 48 h) inhibits the immunosuppressive effect of mouse VISTA-Fc fusion protein and promotes IL-2 secretion by CD-3-activated mouse primary T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VISTA-IN-1 (Compound 6809-0223) (20 mg/kg; p.o.; daily; from day 3 post-inoculation until study termination) demonstrates in vivo tumor inhibitory activity in a mouse B16-F10 melanoma model, with an average tumor volume of 2.43 cm³^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 669749-25-1
Molecular Weight 411.50
Formel C₁₈H₁₇N₇OS₂
SMILES

O=C1N=C(NC=2N=C3C=CC(=CC3=C(N2)C)C)NC(=C1)CSC4=NN=C(S4)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Liu J, et al. There is the micromolecular compound and application thereof of affinity with VISTA. CN108743590A, 2019-02-02.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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