VISTA-IN-1
VISTA-IN-1 is an orally active VISTA inhibitor. VISTA-IN-1 inhibits the function of VISTA and promotes the secretion of IL-2. VISTA-IN-1 exerts inhibitory effects on mouse melanoma in vivo. VISTA-IN-1 is applicable to melanoma-related research.
For research use only. We do not sell to patients.
- CAS No.: 669749-25-1
- Formula: C18H17N7OS2
- Molecular Weight:411.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
VISTA-IN-1 (Compound 6809-0223) (10 μg/mL; 2 h) exhibits strong affinity for mouse VISTA-Fc fusion protein in a competitive ELISA assay, with a binding rate of 16.02%[1].
VISTA-IN-1 (20 μM; 48 h) inhibits the immunosuppressive effect of mouse VISTA-Fc fusion protein and promotes IL-2 secretion by CD-3-activated mouse primary T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 669749-25-1
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Molecular Weight 411.50
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Formula C18H17N7OS2
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SMILES
O=C1N=C(NC=2N=C3C=CC(=CC3=C(N2)C)C)NC(=C1)CSC4=NN=C(S4)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VISTA-IN-1 Related Classifications
HY-149201 Related Classifications
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