Z617487438
Z617487438 is a TRPV1 antagonist. Z617487438 can be used for pain research.
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- 화학식: C23H18F3NO
- 분자량:381.39
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
TRPV1 2.60 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.60 μM
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Inhibition of capsaicin-evoked TRPV1 calcium signaling in HEK293 cells stably expressing human TRPV1 by FDSS/μCELL fluorescent calcium assay using Fluo-4 AM after 20 min compound pre-incubation.
Inhibition of capsaicin-evoked TRPV1 calcium signaling in HEK293 cells stably expressing human TRPV1 by FDSS/μCELL fluorescent calcium assay using Fluo-4 AM after 20 min compound pre-incubation.
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42732743 |
| HEK293 | IC50 |
2.60 μM
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Inhibition of capsaicin-induced TRPV1 currents in HEK293 cells stably expressing TRPV1 by whole-cell patch-clamp electrophysiology with each concentration applied for 1 min to steady state, as reported in the Results section.
Inhibition of capsaicin-induced TRPV1 currents in HEK293 cells stably expressing TRPV1 by whole-cell patch-clamp electrophysiology with each concentration applied for 1 min to steady state, as reported in the Results section.
|
42732743 |
| HEK293 | IC50 |
2.80 μM
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Inhibition of capsaicin-induced TRPV1 currents in HEK293 cells stably expressing TRPV1 by whole-cell patch-clamp electrophysiology with each concentration applied for 1 min to steady state, as reported in the abstract, discussion, and conclusion.
Inhibition of capsaicin-induced TRPV1 currents in HEK293 cells stably expressing TRPV1 by whole-cell patch-clamp electrophysiology with each concentration applied for 1 min to steady state, as reported in the abstract, discussion, and conclusion.
|
42732743 |
In Vitro
Z617487438 (0.12-30 μM; 1-3 min) inhibits Capsaicin-induced TRPV1 currents in HEK293 cells in a concentration-dependent manner, with a patch-clamp IC50 of 2.60 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 381.39
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화학식 C23H18F3NO
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SMILES
O=C(C1=CC(C2=CC=CC=C2C(F)(F)F)=CC=C1)NC3=CC(CCC4)=C4C=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z617487438 Related Classifications
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