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Cat. No.: HY-113482

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1β-Hydroxydeoxycholic acid

Name: 1β-Hydroxydeoxycholic acid
Brand: MedChemExpress
SKU: HY-113482
Price: 410.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: 1β-OH-DCA)

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1β-Hydroxydeoxycholic acid (1β-OH-DCA) is an endogenous bile acid metabolite formed from deoxycholic acid via CYP3A-mediated 1β-hydroxylation. 1β-Hydroxydeoxycholic acid undergoes rapid metabolism in human hepatocytes, primarily through glycine conjugation to form G-1β-OH-DCA, with minor taurine conjugation and sulfation. The urinary ratio of 1β-Hydroxydeoxycholic acid to deoxycholic acid can be used as an endogenous biomarker for assessing CYP3A activity. 1β-Hydroxydeoxycholic acid can be used in metabolism-related research.

For research use only. We do not sell to patients.

Purity : 95.0%
CAS No.: 80434-32-8
Formula: C₂₄H₄₀O₅
Molecular Weight:408.57

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

1β-Hydroxydeoxycholic acid Chemical Structure

CAS No.: 80434-32-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

CYP3A

All Endogenous Metabolite Isoforms :

All Cytochrome P450 Isoforms :

In Vitro

1β-Hydroxydeoxycholic acid (1β-OH-DCA) is the major hydroxylated metabolite generated after incubation of deoxycholic acid (DCA) with human liver microsomes; Ketoconazole (HY-B0105) inhibits the formation of this metabolite in a concentration-dependent manner^[1]^[2]^[3].
1β-Hydroxydeoxycholic acid is generated from DCA by the major recombinant human CYPs-CYP3A4 and CYP3A7, with CYP3A4 activity being much higher than that of CYP3A5^[1].
1β-Hydroxydeoxycholic acid (4 µM; 0-120 min) is rapidly metabolized in human hepatocytes, with 44% of the parent drug remaining at 40 min, and glycine conjugation is the major metabolic pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 80434-32-8
Appearance Solid
Molecular Weight 408.57
Formula C₂₄H₄₀O₅
Color White to off-white
SMILES

C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@@H](C[C@H]2O)O)([H])[C@@]4([H])[C@]([C@H](C3)O)([C@@](CC4)([H])[C@H](C)CCC(O)=O)C
Synonyms

1β-OH-DCA
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hayes MA, et al. CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity. Drug metabolism and disposition: the biological fate of chemicals. 2016 Sep;44(9):1480-9.

[2]. Ma Y, et al. Precision medication based on the evaluation of drug metabolizing enzyme and transporter functions. Precision clinical medicine. 2025 Mar;8(1):pbaf004.

[3]. Tremmel R, et al. Circulating biomarkers instead of genotyping to establish metabolizer phenotypes. Annual Review of Pharmacology and Toxicology. 2024 Jan 23;64(1):65-87.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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