10-Nitrocamptothecin
10-Nitrocamptothecin is a topoisomerase I inhibitor with an IC50 of 0.64 μM. 10-Nitrocamptothecin interferes with the formation of cleavable complexes, thereby inhibiting the activity of Topoisomerase I. 10-Nitrocamptothecin is applicable for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 86639-62-5
- Formula: C20H15N3O6
- Molecular Weight:393.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
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Topoisomerase I 0.64 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HL-60 | IC50 |
0.64 μM
Compound: 5e
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Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells
Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells
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[PMID: 8410981] |
10-Nitrocamptothecin (Compound 5e) (30 min) inhibits purified calf thymus topoisomerase I by forming a cleavable complex, with an IC50 of 0.64 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 86639-62-5
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Molecular Weight 393.35
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Formula C20H15N3O6
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SMILES
O=C1N2C(C(C(C2)=CC3=C4)=NC3=CC=C4[N+]([O-])=O)=CC5=C1COC([C@]5(O)CC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
10-Nitrocamptothecin Related Classifications
HY-N2062 Related Classifications
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