2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. ADC Payload Topoisomerase
  4. (5-Cl)-Exatecan

(5-Cl)-Exatecan is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan is applicable for the research of ROR1-positive cancers.

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(5-Cl)-Exatecan

(5-Cl)-Exatecan 화학구조

CAS No. : 2813268-66-3

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(5-Cl)-Exatecan Related Antibodies

Top Publications Citing Use of Products

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Topoisomerase Topo I Topo II DNA gyrase

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제품 설명

(5-Cl)-Exatecan is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan is applicable for the research of ROR1-positive cancers[1].

IC50 & Target

Camptothecins

 

In Vitro

The ADC compound prepared from (5-Cl)-Exatecan (1-5) and Anti-ROR1 antibody exhibits excellent targeted killing effects on colon cancer and non-small cell lung cancer (e.g., lung adenocarcinoma)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(5-Cl)-Exatecan Related Antibodies
분자량

451.90

화학식

C24H22ClN3O4
CAS No.
SMILES

N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(Cl)=C(C)C(CC1)=C62
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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(5-Cl)-Exatecan Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(5-Cl)-Exatecan2813268-66-3ADC PayloadTopoisomeraseADC CytotoxinROR1-positive cancersDNA topoisomeraseInhibitorinhibitorinhibit

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상품명:
(5-Cl)-Exatecan
Cat. No.:
HY-160806
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