1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. AGN 195183

AGN 195183 

Cat. No.: HY-16684 Purity: 98.40%
Handling Instructions

AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ.

For research use only. We do not sell to patients.

AGN 195183 Chemical Structure

AGN 195183 Chemical Structure

CAS No. : 367273-07-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ. IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.) Target: RARα agonist Compound 4(AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation. Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3, compound 4 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580. Compound 4 (AGN 195183) is currently in Phase I/IIA clinical trials in cancer patients.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 62 mg/mL (141.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2838 mL 11.4192 mL 22.8384 mL
5 mM 0.4568 mL 2.2838 mL 4.5677 mL
10 mM 0.2284 mL 1.1419 mL 2.2838 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

437.86

Formula

C₂₂H₂₂ClF₂NO₄

CAS No.

367273-07-2

SMILES

O=C(O)C1=C(F)C=C(NC(C2=C(O)C(Cl)=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.40%

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Product Name:
AGN 195183
Cat. No.:
HY-16684
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AGN 195183

Cat. No.: HY-16684