CAY10505
Based on 5 publication(s) in Google Scholar
CAY10505 is a potent and selective PI3Kγ inhibitor with an IC50 of 30 nM in neurons.
For research use only. We do not sell to patients.
- Purity : 99.75%
- CAS No.: 1218777-13-9
- Formula: C14H8FNO3S
- Molecular Weight:289.28
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-13531
AS-604850PI3Kγ Inhibitor -
HY-13532
AS-252424PI3K Inhibitor -
HY-15294
CZC24832PI3Kγ Inhibitor -
HY-N0146
Quercetin dihydrateApoptosis Inducer -
HY-100716
EganelisibPI3Kγ Inhibitor -
HY-17044
DuvelisibPI3Kδ Inhibitor -
HY-15244
AlpelisibPI3Kα Inhibitor -
HY-15346
CopanlisibPI3K Inhibitor -
HY-10683
PKI-402PI3K Inhibitor -
HY-10111
TG100-115PI3Kγ/PI3Kδ Inhibitor -
HY-70063
BuparlisibPI3K Inhibitor -
HY-13898
TaselisibPIK3CA Inhibitor
Publications Citing Use of MedChemExpress (MCE) CAY10505
More
Customer Validation & Images
-
WB
Biological Activity
Description
IC50 & Target
[1]|
PI3Kγ 30 nM (IC50, Neurons) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
36.9 μM
Compound: 39b(E)
|
Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay
|
[PMID: 20178321] |
In Vitro
A class IB PI3Kγ isoform inhibitor CAY10505 at 200 nM (IC50=30 nM) partially reduces the baicalein-induced Akt phosphorylation in neurons[1]. The pharmacological PI3K inhibitor CAY10505 (PIK3CG) is tested on an extended panel of multiple myeloma (MM) cell lines and freshly isolated primary MM samples. MM cells are CAY10505-treated for 3 d (MM cell lines) or 5 d (primary MM cells) respectively, and survival is analysed by flow cytometry (annexin V-FITC/PI staining). Treatment of bone marrow stromal cells (BMSCs)-co-cultured primary MM samples with the PIK3CA inhibitor CAY10505 results in anti-survival effects (mean survival relative to DMSO-treated controls: CAY10505: 84±14%, tested at 10 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1218777-13-9
-
Appearance Solid
-
Molecular Weight 289.28
-
Formula C14H8FNO3S
-
Color Light yellow to yellow
-
SMILES
O=C(NC/1=O)SC1=C\C2=CC=C(C3=CC=C(F)C=C3)O2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Nucleic Acids Res
PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining at double-ended DSBs. [Abstract]2026 Jan 5;54(1):gkaf1437. PMID: 41495903 -
Cell Death Dis
MiR-1976 knockdown promotes epithelial-mesenchymal transition and cancer stem cell properties inducing triple-negative breast cancer metastasis. [Abstract]2020 Jul 3;11(7):500. PMID: 32620748
CAY10505 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Jul 3;11(7):500. [Abstract]
The protein expression levels of PIK3CG, AKT, and p-AKT are measured by Western blot. The properties of EMT in SUM-1315 and ZR-75-1 transfected with CAY10505 is determined by wound healing assay.
-
Commun Biol
Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice. [Abstract]2022 Apr 8;5(1):339. PMID: 35396348 -
Molecules
In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei. [Abstract]2020 Apr 23;25(8):1980. PMID: 32340370 -
bioRxiv
PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining during mitosis. [Abstract]2025 Jun 9:2025.06.09.658719. PMID: 40661535
Solvent & Solubility
In Vitro:
DMSO : ≥ 34 mg/mL (117.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
-
Data Sheet (281 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
[1]. Sun YY, Lin SH et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. 2013 Jul 19;8(7):e69019. [Content Brief]
[2]. Tyagi S. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul, 90(7), 881-5. [Content Brief]
[3]. Hofmann C, et al. PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform. Br J Haematol. 2014 Aug;166(4):529-39. [Content Brief]
[4]. Jingyi Wang, et al. MiR-1976 Knockdown Promotes Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties Inducing Triple-Negative Breast Cancer Metastasis. Cell Death Dis. 2020 Jul 3;11(7):500. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4569 mL | 17.2843 mL | 34.5686 mL | 86.4215 mL |
| 5 mM | 0.6914 mL | 3.4569 mL | 6.9137 mL | 17.2843 mL | |
| 10 mM | 0.3457 mL | 1.7284 mL | 3.4569 mL | 8.6421 mL | |
| 15 mM | 0.2305 mL | 1.1523 mL | 2.3046 mL | 5.7614 mL | |
| 20 mM | 0.1728 mL | 0.8642 mL | 1.7284 mL | 4.3211 mL | |
| 25 mM | 0.1383 mL | 0.6914 mL | 1.3827 mL | 3.4569 mL | |
| 30 mM | 0.1152 mL | 0.5761 mL | 1.1523 mL | 2.8807 mL | |
| 40 mM | 0.0864 mL | 0.4321 mL | 0.8642 mL | 2.1605 mL | |
| 50 mM | 0.0691 mL | 0.3457 mL | 0.6914 mL | 1.7284 mL | |
| 60 mM | 0.0576 mL | 0.2881 mL | 0.5761 mL | 1.4404 mL | |
| 80 mM | 0.0432 mL | 0.2161 mL | 0.4321 mL | 1.0803 mL | |
| 100 mM | 0.0346 mL | 0.1728 mL | 0.3457 mL | 0.8642 mL |
CAY10505 Related Classifications
HY-13530 Related Classifications
Powered by Bioz