GSK376501A
GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.
For research use only. We do not sell to patients.
- Purity : 99.06%
- CAS No.: 1010412-80-2
- Formula: C32H37NO6
- Molecular Weight:531.64
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
PPARγ |
Chemical Information
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CAS No. 1010412-80-2
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Appearance Solid
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Molecular Weight 531.64
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Formula C32H37NO6
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Color White to off-white
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SMILES
O=C(C(N1CC2=CC(OCCOC)=CC(OCCOC)=C2)=C(C3=CC=C(C(C)(C)C)C=C3)C4=C1C=CC=C4)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (188.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8810 mL | 9.4049 mL | 18.8097 mL | 47.0243 mL |
| 5 mM | 0.3762 mL | 1.8810 mL | 3.7619 mL | 9.4049 mL | |
| 10 mM | 0.1881 mL | 0.9405 mL | 1.8810 mL | 4.7024 mL | |
| 15 mM | 0.1254 mL | 0.6270 mL | 1.2540 mL | 3.1350 mL | |
| 20 mM | 0.0940 mL | 0.4702 mL | 0.9405 mL | 2.3512 mL | |
| 25 mM | 0.0752 mL | 0.3762 mL | 0.7524 mL | 1.8810 mL | |
| 30 mM | 0.0627 mL | 0.3135 mL | 0.6270 mL | 1.5675 mL | |
| 40 mM | 0.0470 mL | 0.2351 mL | 0.4702 mL | 1.1756 mL | |
| 50 mM | 0.0376 mL | 0.1881 mL | 0.3762 mL | 0.9405 mL | |
| 60 mM | 0.0313 mL | 0.1567 mL | 0.3135 mL | 0.7837 mL | |
| 80 mM | 0.0235 mL | 0.1176 mL | 0.2351 mL | 0.5878 mL | |
| 100 mM | 0.0188 mL | 0.0940 mL | 0.1881 mL | 0.4702 mL |
GSK376501A Related Classifications
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