2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Mefexamide

Mefexamide (ANP-297) is a psychostimulant psychopharmaceutical and aryloxyacetic acid derivative antidepressant with dopaminergic activity. Mefexamide can be used for the research of depression.

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Mefexamide

Mefexamide Chemical Structure

CAS No. : 1227-61-8

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Mefexamide Related Antibodies

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Description

Mefexamide (ANP-297) is a psychostimulant psychopharmaceutical and aryloxyacetic acid derivative antidepressant with dopaminergic activity. Mefexamide can be used for the research of depression[1][2].

In Vitro

Mefexamide (1 g; 15 min refluxed) undergoes acid hydrolysis to yield four breakdown products, and the compound exhibits distinct spectroscopic and chromatographic profiles, including a melting point of 112 °C, UV absorption maximum at 285 nm, and characteristic EI/CI mass spectra[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mefexamide Related Antibodies
In Vivo

Mefexamide (i.v. perfusion) demonstrates sympathomimetic activity by reversing Reserpine (HY-N0480)-induced ptosis in male Fauve de Bourgogne rabbits[2].
Mefexamide reverses Tetrabenazine (HY-B0590)-induced ptosis in male Wistar rats[2].
Mefexamide (5-20 mg/kg; i.v.; singer dose) significantly potentiates LSD-25-induced hyperthermia in male rabbits[2].
Mefexamide (5-20 mg/kg; i.v.; singer dose) potentiates Noradrenaline (HY-13715)-induced hyperthermia in male rabbits, with less significant effects than seen with LSD-25[2].
Mefexamide (10 mg/kg; i.v.; singer dose) protects against Reserpine (HY-N0480)-induced lowering of the bemegride convulsion threshold in male rabbits[2].
Mefexamide (10 mg/kg; i.v.; singer dose) does not significantly alter the EEG of normal male rabbits[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rabbit (male)[2]
Dosage: 5.0 mg/kg; 20.0 mg/kg
Administration: i.v.; singer dose
Result: Significantly potentiated LSD-25-induced hyperthermia in rabbits, mirroring the activity of cocaine.
Animal Model: Rabbit (male)[2]
Dosage: 5.0 mg/kg; 20.0 mg/kg
Administration: i.v.; singer dose
Result: Potentiated noradrenaline-induced hyperthermia in rabbits, with a similar activity profile to that observed with LSD-25, though effects were less significant.
Animal Model: Rabbit (male)[2]
Dosage: 10 mg/kg
Administration: i.v.; singer dose
Result: Reversed the reserpine-induced reduction in bemegride convulsion threshold, demonstrating antagonist activity similar to cocaine.
Animal Model: Rabbit (male)[2]
Dosage: 10 mg/kg
Administration: i.v.; singer dose
Result: Did not significantly modify the EEG of normal male Giant of Flanders rabbits, with no notable induction of large slow waves.
Molecular Weight

280.36

Formula

C15H24N2O3
CAS No.
SMILES

O=C(NCCN(CC)CC)COC1=CC=C(OC)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mefexamide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mefexamide1227-61-8ANP-297ANP297ANP 297Dopamine Receptorrabbitspsychopharmaceuticalratsdopaminergic activityhumanscatecholaminesantidepressantaryloxyacetic acid derivativemicepsychostimulantInhibitorinhibitorinhibit

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