Infection

Anti-neuroinflammation agent 2 (compound 4) demonstrates anti-neuroinflammatory and antibacterial activities, with IC₅₀ values of 3.06 µM for TNF-α and 4.31 µM for IL-6, alongside EC₅₀ values ranging from 0.87 to 3.16 µM against Gram-positive bacteria.

Milrinone solution is mainly composed of Milrinone (HY-14252). Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.

Xibornol (Bactacine) has strong antibacterial action against Streptococcus pneumoniae, Streptococcus pyogenes, and Staphyloccus aureus, as well as against Actinomyces israelii and Corynebacterium ulcerans. Xibornol has the potential for using for the antisepsis of the oral cavity and as adjuvant in pharyngeal infections caused by Gram-positive microorganisms.

Moniliformin-¹³C₄ sodium is the ¹³C-labeled Moniliformin sodium (HY-101905). Moniliformin sodium salt is a potent mycotoxin isolate from Fusarium moniliforme.

Acacia farnesiana extract is an extract of Acacia farnesiana that can inhibit Mycobacterium tuberculosis and Shigella dysenteriae.

Leucinostatin K is a peptide antibiotic with anti-gram-positive bacterial and fungal effects, which is found in Paecilomyces lilacinus.

Lamivudine impurity 9 is an L-oxathiolanyl nucleoside. Lamivudine impurity 9 exhibits anti-HIV-1 activity with EC₅₀ > 100 μM in human peripheral blood mononuclear cells, and it shows no cytotoxicity even at concentrations up to 100 μM in human peripheral blood mononuclear cells and Vero cells.

L 756423 is a potent HIV protease inhibitor. L 756423 has the potential for the research of HIV infection.

Naftifine-¹³C,d₃ is the ¹³C- and deuterium labeled Naftifine. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition.

CDA-IN-3 (NCDI) is an inhibitor of chitin deacetylase (CDA) with anti-parasitic activity. CDA-IN-3 disrupts the chitin metabolism of nematodes, leading to an increase in the level of ROS in nematodes and causing cell damage. CDA-IN-3 has a significant inhibitory effect on all developmental stages of Caenorhabditis elegans. CDA-IN-3 can be used in the research of the anti-infection field .

CouCyCF3 is a fluorescent probe for bacterial cytoplasmic pH, with a pKa of 7.0. CouCyCF3 can be taken up by both Gram-positive and Gram-negative bacteria. Under acidic conditions, the fluorescence of CouCyCF3 in the red channel increases, while its fluorescence in the blue channel increases with elevated pH. A linear quantitative response is achieved via the I_red/I_blue ratio within the pH range of 5.0-7.5, with excitation/emission wavelengths of 445/472 nm (blue) and 640/708 nm (red). CouCyCF3 can be used for studies on bacterial acid tolerance and phagolysosome acidification.

Rabdoserrin A is a diterpenoid. Rabdoserrin A has antifungal activity.

Pravibismane (BisEDT; MBN-101) is a broad-spectrum topical anti-infective and anti-biofilm agent. Pravibismane disrupts bacterial bioenergetics by reducing bacterial concentrations of ATP in both planktonic and biofilm phenotypes and exhibits potent anti-biofilm activity against diabetic foot infections (DFI)-relevant pathogens, such as S. aureus and P. aeruginosa. Pravibismane can be used for the study of diabetic foot infections.

Kapurimycin A3 is an antitumor and antibacterial antibiotic. Kapurimycin A3 has DNA binding and breakage activity. Kapurimycin A3 can be isolated from Streptomyces.

HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC₅₀ values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA＞452 μg/mL) and good PK property with no cellular toxicity.

Maximin 28 is an antimicrobial peptide derived from the toad brain. Maximin 28 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 4.7, 9.4, 75 μg/mL, respectively.

Myristic acid-d is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.

AMG 1541 is a degradable ionizable lipid. AMG 1541 mediates the delivery of polynucleotides including mRNA. AMG 1541 exerts potent neutralizing effects on pseudotyped lentiviruses carrying the B.1.617.2 spike protein. As a component of influenza vaccines, AMG 1541 enables robust immune activation and reduces vaccine dosage. AMG 1541 is applicable to research related to SARS-CoV-2 infection.

Bac8c is an antimicrobial peptide with strong antibacterial activity against Gram-negative and Gram-positive bacteria. The MIC of Bac8c against S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa are 2, 8, 4, 4, and 4 μg/mL, respectively.

MC-PEG4-β-Glu-Baloxavir is a conjugate of a toxin molecule and a linker, with Baloxavir (HY-109025A) as the payload. Baloxavir is an effective and selective inhibitor of cap-dependent nucleases (CEN). Baloxavir inhibits the transcription and replication of viral RNA and has strong antiviral activity.