Infection

Cephalosporin C analog-1 is an analogue of Cephalosporin C (HY-B1299). Cephalosporin C has weak resistance to Gram-positive and negative bacteria, is stable to penicillinase, and can be broken down by cephalosporin enzyme. Hydrolysis and removal of side chains to obtain 7-amino-cefenoic acid (7-ACA) is an important raw material for the preparation of semi-synthetic cephalosporin.

Gemifloxacin (mesylate) (Standard) is the analytical standard of Gemifloxacin (mesylate). This product is intended for research and analytical applications. Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections.

Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities.

Cefiderocol-d₆ (S-649266-d₆) is a deuterated labeled Cefiderocol (HY-17628). Cefiderocol is a siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50s of 2 μg/mL or less.

Ethyl nonanoate Standard is the analytical standard of Ethyl nonanoate (HY-129623). This product is intended for research and analytical applications. Ethyl nonanoate is an orally active medium-chain fatty acid ethyl ester and aroma compound present in Laimao baijiu, cachaca, and distilled spirits. Ethyl nonanoate is catalytically converted to azelaic acid as a nonanoic acid precursor derivative with cytotoxicity. Ethyl nonanoate is used as a food flavoring agent. Ethyl nonanoate exhibits antifungal activity.

Pluraflavin A is an antitumor antibiotic. Pluraflavin A has the effect of inhibiting the transcription of glucose-6-phosphatase gene and has good anti-proliferation activity on tumor cells.

cOB1 phermone, a bacterial sex pheromone, effectively inhibits multidrug-resistant Enterococcus faecalis V583.

Phyllanthin (Standard) is the analytical standard of Phyllanthin. This product is intended for research and analytical applications. Phyllanthin is an effective oral anticancer agent. Phyllanthin inhibits MOLT-4 cell viability, increases apoptosis, inhibits cell migration and invasion. Phyllanthin exerts anti-fibrotic effects by down-regulating TGF signaling pathway via ALK5 and Smad2/3. Phyllanthin also has anti-inflammatory and antibacterial properties .

Apo6619 is an iron chelator with antibacterial activity that inhibits a variety of common bacteria associated with hospital-acquired infections. Apo6619 inhibits the growth of relevant bacterial strains in cation-adjusted Mueller-Hinton broth and RPMI 1640 tissue culture medium. Apo6619 can be used in antibacterial research on hospital-acquired infection-related bacteria based on the iron chelation mechanism.

Iodoantipyrine (Standard) is the analytical standard of Iodoantipyrine. This product is intended for research and analytical applications. Iodoantipyrine (4-Iodoantipyrine) is an iodinated Antipyrine (HY-B0171) with potential antiviral activity. Antipyrine (Phenazone) is an antipyretic and analgesic that also serves as a molecular probe of hepatic oxidative metabolites.

Pyrisulfoxin B is an antibiotic found in Streptomyces callfornicus BS-75.

NEU-1017 is a broad-spectrum antiparasitic agent. NEU-1017 inhibits T. brucei, L. major, and P. falciparum with EC₅₀ values of 210 nM, 240 nM, and 3 nM, respectively. X

(4-Aminobenzoyl)-D-glutamic acid (Compound 17) exhibits competitive inhibitory activity against H₂-pteroate synthesis system, which affects the synthesis of folate, thereby inhibiting growth of bacteria.

Chartreusin sodium is an antibiotic that is active against certain Gram-positive organisms and mycobacteria. Chartreusin is also active against the Micrococcus fiyogenes v. aureus phage.

Oryzalin (Standard) is the analytical standard of Oryzalin (HY-147092). This product is intended for research and analytical applications. Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling.

Toremifene (citrate) (Standard) is the analytical standard of Toremifene (citrate). This product is intended for research and analytical applications. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively.

Polymyxin A2 is a heteropeptide antibiotic found in different strains of Bacillus polymyxa, and its effect against Gram-negative bacteria is greater than that against Gram-positive bacteria.

DL25 is a fungicide with an IC₅₀ of 5.0 μg/mL against Mycobacterium tuberculosis DHQS. DL25 binds with high affinity to mycobacterial targets LysA, LpdA and SecA1. DL25 exhibits broad-spectrum anti-mycobacterial activity against multiple mycobacterial species and shows partial synergy with established anti-tuberculosis drugs. DL25 can be used in studies related to tuberculosis.

Ravuconazole (Standard) is the analytical standard of Ravuconazole. This product is intended for research and analytical applications. Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.

DENV ligand 1 is a ligand for DENV E protein. DENV ligand 1 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806).