Infection

Carbonic acid is a diprotic acid, acidulant and anesthetic. Carbonic acid penetrates living cells more easily than most other acids, exhibits stronger toxicity than inorganic acids at equivalent concentrations, and exacerbates ocean acidification. Carbonic acid binds reversibly to cellular proteins, acidifies cell sap and protoplasmic inclusions, inhibits Paramecium growth and various cellular functions, induces reversible cellular changes, produces lethal effects at high doses, decomposes into carbon dioxide and H₂O, and participates in the maintenance of physiological pH balance.

8''-Hydroxypactamycin is an antibiotic found in Streptomyces SIPI-A-3-0121.

Carbocisteine-d₃ (Carbocysteine-d₃) is deuterium labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research.

Scytalol C is a natural compound found in the strain of Scytalidium sp. 36-93.

Sulfamerazine-d₄ is a deuterium labeled Sulfamerazine. Sulfamerazine (RP2632) is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein K_D of 352 μM. Sulfamerazine inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine can be used for the research of Parkinson’s disease and bacterial infection.

RU44790 is a monocyclic beta-lactam antibiotic that exerts potent activity against gram-negative bacteria and is highly resistant to hydrolysis by various beta-lactamases. RU44790 can be utilized in anti-bacteria research.

Fmoc-L-Lys (Boc)-OH-¹³C₆,¹⁵N₂ is a ¹⁵N-labeled and ¹³C-labled Fmoc-L-Lys (Boc)-OH (HY-79128). Fmoc-L-Lys (Boc)-OH is a lysine derivative.

Maridomycin V is a macrolide antibiotic. Maridomycin Vhas the activity against Gram-positive bacteria and mycoplasma. Maridomycin V has the effect of protecting Gram-positive bacterial infection mice.

α-Prumycin hydrochloride is a carbohydrate antibiotic. α-Prumycin hydrochloride has anti-fungal activity and weak anti-individual bacterial activity.

Ceftaroline chloride hydrochloride (T-91825 chloride hydrochloride) is a cephalosporin compound and the active form of Ceftaroline fosamil (HY-14737). Ceftaroline chloride hydrochloride exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria. Ceftaroline chloride hydrochloride binds to penicillin-binding proteins 2 and 2A, thereby inhibiting the synthesis of bacterial peptidoglycan and cell wall, and acts as a bactericide, synergist, and resistance inhibitor. Ceftaroline chloride hydrochloride can be used in research related to complicated skin and soft tissue infections, community-acquired pneumonia, Enterococcus faecalis infective endocarditis, and bacterial infections.

Fluvirucin B3 is an antibiotic against influenza A virus.

Minosaminomycin is an antibiotic containing myo-inosamine that can be extracted from Streptomyces No. MA514A1. Minosaminomycin exerts antimicrobial activity against Mycobacterium smegrnatis ATCC 607 and Mycobacterium phlei (MIC= 1.56/6.25 mcg/mL).

Fusaricidin B (LI-F 04b) is a lipopeptide biosurfactant. Fusaricidin B can be isolated from the culture broth of Bacillus polymyxa KT-8. Fusaricidin B exhibits activity against Gram-positive bacteria (especially Staphylococcus aureus FDA 209P and Micrococcus luteus IFO 3333), but its activity is weaker than that of the mixture of Fusaricidin C and D.

Nocardicyclin A is resistant to Gram-positive bacteria, mycobacterium and Nocardia.

2'-Deoxyuridine 5'-monophosphate (dUMP) is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis.

Ningnanmycin is a plant antiviral agent. Ningnanmycin binds to specific residues on the TMV CP disc, inhibits CP assembly, disassembles the CP disc into monomers, and disrupts the structure of the TMV CP disc to reduce pathogenicity. Ningnanmycin binds to key amino acids of PVY CP, interferes with CP-CP interactions, inhibits CP assembly and virion formation, and blocks PVY replication. Ningnanmycin induces the expression of antiviral response genes PRXIIB, PRXIIE, PUB4 and PER42, thereby activating the host defense system. Ningnanmycin can be used in studies related to Tobacco Mosaic Virus infection and Potato Virus Y infection.

1,5-Dimethylnaphthalene is a volatile organic compound. 1,5-Dimethylnaphthalene is a good marker for B. cinerea quantification. 1,5-dimethylnaphthalene is highly positively correlated to B. cinerea infection levels in Chardonnay berries.

Chloronectrin has anti-Gram-positive bacterial activity.

NNRT-IN-15 (Compound 16a) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-15 shows an EC₅₀ of 3 nM for WT HIV-1 and inhibits seven mutant strains (L100I, K103N, Y181C, etc.) (EC₅₀ = 8.2-43.4 nM). NNRT-IN-15 has low cytotoxicity against MT-4 cells (CC₅₀ = 196.46 μM). NNRT-IN-15 also inhibit WTHIV-1RT and hERG with IC₅₀ values of 0.7599 μM and 27.455 μM. NNRT-IN-15 can be used for research of HIV-1 infection.

Temephos (Standard) is the analytical standard of Temephos. This product is intended for research and analytical applications. Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis.