Infection

Chloronectrin has anti-Gram-positive bacterial activity.

Dioxadrol is an uncompetitive NMDA receptor (PCP binding site) antagonist, with a K_i value of 10.9 nM in pigs. Dioxadrol binds to the phencyclidine (PCP) binding site within the cation channel associated with the NMDA receptor, thereby blocking cation influx. Dioxadrol possesses local anesthetic, spasmolytic and central nervous system activities, including phencyclidine-like dissociative anesthetic properties. Dioxadrol can be used in the research of Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV-associated dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, ischemic stroke, central nervous system trauma, and epilepsy.

Antiparasitic agent-44 is an orally active Antiparasitic agent. Antiparasitic agent-44 reduces parasitemia levels, ROS, reactive nitrogen, lipid oxidation, protein oxidation, inflammatory responses and microstructural damage in Trypanosoma cruzi-infected mice. Antiparasitic agent-44 can be used for the research of Chagas disease.

Oleic acid diethanolamide (OADA) is a non-ionic, biodegradable surfactant. Oleic acid diethanolamide reduces the surface tension of water, emulsifies free water in diesel fuel to form a stable emulsion, and can be loaded onto sulfonated polystyrene nanoparticles to enhance oil recovery. Oleic acid diethanolamide is one of the nematicidal secondary metabolites produced by Aspergillus flavus. Oleic acid diethanolamide can be used in studies related to biological control of root-knot nematodes, enhanced oil recovery, and diesel fuel emulsion stabilization.

CHIKV nsP2 protease-IN-3 (Compound 5) is an irreversible covalent inhibitor targeting the nonstructural protein 2 (nsP2) cysteine protease of chikungunya virus (CHIKV) (IC₅₀=0.5 μM). CHIKV nsP2 protease-IN-3 inhibits viral RNA replication. CHIKV nsP2 protease-IN-3 is promising for research of alphaviruses.

SARS-CoV-2-IN-70 (compound 6) is a potent inhibitor of SARS-CoV-2 with an IC₅₀ of 3.2 μM.

Acremonol has anti-Gram-positive bacteria and fungal activity.

Sulfamerazine-d₄ is a deuterium labeled Sulfamerazine. Sulfamerazine (RP2632) is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein K_D of 352 μM. Sulfamerazine inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine can be used for the research of Parkinson’s disease and bacterial infection.

γ-Cyhalothrin is an orally active, blood-brain barrier permeable Type II synthetic pyrethroid insecticide. γ-Cyhalothrin is the insecticidally active enantiomer of λ-Cyhalothrin (HY-B0836). γ-Cyhalothrin disrupts voltage-gated sodium channels, induces salivation and reduces spontaneous activity in rats. γ-Cyhalothrin exerts toxic effects on aquatic invertebrates and fish, triggers community-level effects in aquatic ecosystems, and inhibits host-seeking Ixodes scapularis nymphs in residential lawn ecotones. γ-Cyhalothrin is applicable to insecticidal-related research.

PAN endonuclease-IN-4 (Compound 41) is an inhibitor of PAN endonuclease with antiviral properties. PAN endonuclease-IN-4 is the prodrug of 39-(S). PAN endonuclease-IN-4 can significantly suppress viral replication in an A/WSN/33 infected mouse model.

Leucomycin A7 is a member of the leucomycin complex that can be isolated from Streptomyces kitasatoensis. Leucomycin A7 has antibacterial activity and has strong inhibitory effects on the growth of Gram-positive bacteria, but weak inhibitory effects on Gram-negative bacteria.

Ziresovir (Standard) is the analytical standard of Ziresovir (HY-109142). This product is intended for research and analytical applications. Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC₅₀=3 nM) and highlights pharmacoK_inetics in animal species.

Rpi-856 C is an Aspartic protease inhibitor, with an IC₅₀ of 5.5 nM against HIV-1 protease, 9.2 nM against HTLV-I protease, 2.0 μM against Cathepsin D, and 4.8 μM against Pepsin. Rpi-856 C is produced by the Streptomyces strain AL-322. Rpi-856 C does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 C can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection.

Entecavir (monohydrate) (Standard) is the analytical standard of Entecavir (monohydrate). This product is intended for research and analytical applications. Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor of HBV, with an EC₅₀ of 3.75 nM in HepG2 cell.

Maridomycin V is a macrolide antibiotic. Maridomycin Vhas the activity against Gram-positive bacteria and mycoplasma. Maridomycin V has the effect of protecting Gram-positive bacterial infection mice.

CT 2576 is a phospholipid signaling inhibitor as well as a Jak3/STAT5 inhibitor. CT 2576 suppresses gene expression and replication of human immunodeficiency virus (HIV) at the post-transcriptional level by interfering with phospholipid metabolism in host cells, particularly by inhibiting the production of phosphatidic acid PA. CT-2576 completely inhibits the growth and proliferation of malignant T-cell lymphoma cells by suppressing phospholipid signaling and blocking the Jak/STAT signaling pathway associated with IL-2R. CT 2576 can be used in research related to human immunodeficiency virus (HIV) infection and cutaneous T-cell lymphoma (CTCL).

Sulfometuron-methyl (Standard) is the analytical standard of Sulfometuron-methyl. This product is intended for research and analytical applications. Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III.

Sannamycin F is an aminoglycoside antibiotic. Sannamycin F has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.

Nithiazine is a neonicotinoid insecticide that induces death in adult house flies via ingestion of sugar baits. The resistance level to Nithiazine is low.

Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields.