ADC Payloads
ADC Cytotoxins
ADC payloads are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a payload. The payload is the most important component as it determines the potency to kill cancer cells of an ADC.
There are many payloads which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors.
ADC Payloads Isoform Specific Products
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ADC Payloads
(219)
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Auristatin
(15)
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Calicheamicins
(1)
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Camptothecins
(42)
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Daunorubicins/
Doxorubicins (11)View all products
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Duocarmycins
(18)
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Maytansinoids
(10)
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Pyrrolobenzodiazepines
(8)
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Traditional Cytotoxic Agents
(24)
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All Product Categories
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ADC Payloads Related Products (372)
Related Products (372)
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Antibodies (2)
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Related Compound Screening Libraries (1)
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ADC Payloads Isoform Comparison
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Duocarmycin analog-1
0 ImagesCat. No.: HY-129355CAS No.: 372954-15-9Duocarmycin analog-1 is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin.
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Camptothecin-d5
0 ImagesSynonyms: Campathecin-d5; (S)-(+)-Camptothecin-d5; CPT-d5Camptothecin-d5 is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.
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Glucocorticoid receptor agonist-4
0 ImagesGlucocorticoid receptor agonist-4 (Compound Preparation 5) is a glucocorticoid receptor agonist that can be conjugated to TNF-α antibodies for the study of autoimmune and inflammatory diseases.
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Gly-7-MAD-MDCPT
0 ImagesCat. No.: HY-132164CAS No.: 2378427-68-8Gly-7-MAD-MDCPT (compound 4b) is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin (HY-16560) compound, it shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM.
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Glucocorticoid receptor agonist-3
0 ImagesGlucocorticoid receptor agonist-3 (Preparation 6) is a glucocorticoid receptor agonist.
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Maytansinoid DM4
0 ImagesCat. No.: HY-100503CAS No.: 799840-96-3Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC.
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(4-NH2)-Exatecan-d5
0 ImagesCat. No.: HY-145397SPurity: 98.62%Synonyms: AZ14170132-d5(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan. (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs).
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PY-4Car2
0 ImagesCat. No.: HY-183912CAS No.: 3054643-04-5PY-4Car2 is a Camptothecin (HY-16560) derivative and a topoisomerase I inhibitor. PY-4Car2 functions as a warhead conjugated via a cleavable linker to the bispecific ADC TJ101. PY-4Car2 can be used as an ADC payload for the research of cancers.
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(1R,9S)-Dxd
0 ImagesCat. No.: HY-13631KCAS No.: 2766786-58-5(1R,9S)-Dxd is an isomer of (Dxd) HY-13631D. (1R,9S)-Dxd is an ADC payload that can be used in the synthesis of ADCs (antibody-drug conjugates).
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(5-Cl)-DXd
0 ImagesCat. No.: HY-W1124025CAS No.: 2813268-45-8(5-Cl)-DXd, a derivative of DXd (HY-13631), is a cytotoxic drug that can be used in synthesis of CDH3-targeting antibody-drug conjugates (ADCs).
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RSL3-NH2
0 ImagesCat. No.: HY-175615CAS No.: 3051815-39-2RSL3-NH2 is a GPX4 inhibitor and ferroptosis inducer. RSL3-NH2 triggers the iron-dependent cell death pathway associated with lipid peroxidation by inhibiting GPX4 activity. RSL3-NH2 exhibits significant cytotoxicity against colorectal cancer cells and effectively induces their ferroptosis. RSL3-NH2 can serve as a ADC payload for synthesizing antibody-drug conjugates (ADC) and be used in colorectal cancer-related research.
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Top1 inhibitor 1
0 ImagesTop1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM.
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eIF4A-IN-1 intermediate
0 ImagesCat. No.: HY-176844CAS No.: 3083978-00-8eIF4A-IN-1 intermediate (Compound 71E) is an intermediate of Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-1 intermediate can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
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(5-Cl)-Exatecan
0 ImagesCat. No.: HY-160806CAS No.: 2813268-66-3(5-Cl)-Exatecan is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan is applicable for the research of ROR1-positive cancers.
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Z56
0 ImagesCat. No.: HY-178837CAS No.: 3077480-61-3Z56 is a Ras protein inhibitor. Z56 can be used for the research of cancer, such as pancreatic cancer.
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Camptothecin (Standard)
0 ImagesSynonyms: Campathecin (Standard); (S)-(+)-Camptothecin (Standard); CPT (Standard)Camptothecin (Standard) (Campathecin (Standard)) is the analytical standard of Camptothecin (HY-16560). This product is intended for research and analytical applications. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.
