Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1258)
Related Products (1258)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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ERG-IN-7
0 ImagesCat. No.: HY-184190ERG-IN-7 is a Nav1.5, Cav1.2 and Kv11.1 inhibitor with IC50 values of 10.34 μM, 21.01 μM, and 16.385 μM for human Nav1.5, Cav1.2, and Kv11.1, respectively. ERG-IN-7 prolongs action potentials, reduces conduction velocity, and restores cardiac function. ERG-IN-7 can be used for the research of ventricular arrhythmia.
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Phenchlobenpyrrone
0 ImagesCat. No.: HY-119492CAS No.: 215036-81-0Phenchlobenpyrrone is a highly selective neuronal calcium antagonist that crosses the blood-brain barrier. Phenchlobenpyrrone mildly inhibits AChE activity. Phenchlobenpyrrone inhibits Aβ aggregation and promotes the clearance of Aβ oligomers. Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. Phenchlobenpyrrone may be used in research on Alzheimer's disease.
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Catharanthine (Standard)
0 ImagesSynonyms: (+)-3,4-Didehydrocoronaridine (Standard)Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity.
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Atagabalin hydrochloride
0 ImagesCat. No.: HY-14856BCAS No.: 223445-67-8Synonyms: PD 0200390 hydrochlorideAtagabalin hydrochloride (PD 0200390 hydrochloride) is a Voltage-gated Calcium channel α2δ subunit binder with an IC50 of 22 nM. Atagabalin hydrochloride regulates neurotransmitter release by inhibiting calcium influx at high neuronal firing rates. Atagabalin hydrochloride can be used in research related to sleep disorders.
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Niguldipine
0 ImagesCat. No.: HY-101390BCAS No.: 102993-22-6Niguldipine is a calcium channel blocker with activity in regulating cardiovascular function. Niguldipine can reduce systolic and diastolic blood pressure, thereby increasing heart rate and cardiac output. Niguldipine exhibits dose-dependent and sustained increases in coronary blood flow. Niguldipine also increases perfusion in the kidneys and femoral arteries, but the effect is temporary and to a lesser extent. The effect of Niguldipine on myocardial metabolism is not significant.
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Ginsenoside Rf (Standard)
0 ImagesCat. No.: HY-N0601RCAS No.: 52286-58-5Synonyms: Panaxoside Rf (Standard)Ginsenoside Rf (Standard) is the analytical standard of Ginsenoside Rf. This product is intended for research and analytical applications. Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
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ω-Grammotoxin SIA
0 ImagesCat. No.: HY-P2699CAS No.: 152617-90-8Synonyms: GrTx; ω-GsTx SIAω-Grammotoxin SIA (GrTx) is P/Q and N-type voltage-gated Calcium channels inhibitor. ω-Grammotoxin SIA is also a protein toxin that can be obtained from spider venom. ω-Grammotoxin SIA has the potential to study neurological diseases as well as cardiovascular diseases.
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L-Phenylalanine-d1
0 ImagesCat. No.: HY-178251SCAS No.: 55836-70-9L-Phenylalanine-d is the deuterium labeled L-Phenylalanine (HY-N0215). L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
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N-Desalkylflurazepam (Standard)
0 ImagesSynonyms: Norfludiazepam (Standard)N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively.
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Landiolol-d8
0 ImagesCat. No.: HY-100607SSynonyms: ONO1101-d8Landiolol-d8 (ONO1101-d8) is the deuterium labeled Landiolol (HY-100607). Landiolol (ONO1101) is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.
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HCA-6
0 ImagesCat. No.: HY-179026HCA-6 is a calcium-channel and P-glycoprotein blocker. HCA-6 can induce cancer cells apoptosis and increase anticancer activity of Cisplatin (HY-17394). HCA-6 also exhibits antibacterial activity against Bacillus subtilis. HCA-6 can be used for the research of cancer and infection, such as breast cancer.
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Insecticidal agent 41
0 ImagesCat. No.: HY-189402CAS No.: 3127631-07-3Insecticidal agent 41 is a potent agonist of muscarinic acetylcholine receptors (mAChRs) (with an EC50 of 2.73 μM for M1 mAChR) and an insecticide (LC50 = 42.0 mg/L). Insecticidal agent 41 binds to and agonizes insect mAChRs, induces intracellular calcium influx, and causes mosquitoes to become hyperexcitable, paralyzed, and eventually die. Insecticidal agent 41 can be used in the research and development of mosquito insecticides.
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Iganidipine dihydrochloride
0 ImagesCat. No.: HY-101685ACAS No.: 117241-46-0Synonyms: NKY-722Iganidipine dihydrochloride is a Ca2+ antagonist.
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(S)-Albuterol hydrochloride
0 ImagesCat. No.: HY-137311CAS No.: 50293-91-9(S)-Albuterol hydrochloride is a muscarinic receptor and phospholipase C activator. (S)-Albuterol hydrochloride increases intracellular free calcium in airway smooth muscle.
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Nilvadipine-d4
0 ImagesCat. No.: HY-14284SCAS No.: 2928067-26-7Nilvadipine-d4 is deuterium labeled Nilvadipine. Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.
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(Rac)-NNC 55-0396
0 ImagesCat. No.: HY-50722ACAS No.: 2517420-92-5(Rac)-NNC 55-0396 is the racemate of NNC 55-0396 (HY-50722).
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Farnesyl pyrophosphate
0 ImagesCat. No.: HY-113037BCAS No.: 372-97-4Synonyms: Farnesyl diphosphateFarnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.
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BN 50341
0 ImagesCat. No.: HY-116400CAS No.: 107550-66-3BN 50341 is an orally active anticalcic agent and a benzazepine derivative. BN 50341 decreases the in vivo electrically induced thrombus formation in rat or guinea-pig artery and can be utilized in cardiovascular research.
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Diltiazem-d5 hydrochloride
0 ImagesCat. No.: HY-14656S3CAS No.: 2012598-70-6Synonyms: CRD-401-d5Diltiazem-d5 (CRD-401-d5) hydrochloride is deuterium-labeled Diltiazem (hydrochloride) (HY-14656).
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(rel)-Mirogabalin
0 ImagesCat. No.: HY-12650ACAS No.: 1138244-97-9Synonyms: (rel)-DS5565(rel)-Mirogabalin ((rel)-DS5565) is a voltage-dependent calcium channel inhibitor that acts on the α2δ-1 subunit.
