Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1248)
Related Products (1248)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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AChE/BChE-IN-21
0 ImagesCat. No.: HY-168031CAS No.: 2756368-79-1AChE/BChE-IN-21 is a histamine H3 receptor antagonist, calcium channel blocker, and acetylcholinesterase inhibitor. AChE/BChE-IN-21 exhibits neuroprotective activity against H2O2 and Aβ1-40, and can restore cognitive function in AD mice.
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Evariquinone
0 ImagesCat. No.: HY-118817CAS No.: 594860-23-8Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca2+, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.).
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Multi-kinase-IN-10
0 ImagesCat. No.: HY-180892Multi-kinase-IN-10 (Compound IIIk) is a multi-kinase inhibitor. Multi-kinase-IN-10 exhibits significant calcium channel blocking activity, with its IC50 being 26.67 μM. Multi-kinase-IN-10 is a potent dual cholinesterase inhibitor, with its IC50 values for hAChE and hBuChE being 0.304 μM and 1.033 μM respectively. Multi-kinase-IN-10 has antioxidant and neuroprotective activities, and shows significant anti-amnesia activity. Multi-kinase-IN-10 can be used for research on Alzheimer's disease.
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ω-Tbo-IT1
0 ImagesCat. No.: HY-P5140ω-Tbo-IT1 is a peptide toxin that can be isolated from the venom of Tibellus oblongus.ω-Tbo-IT1 is an inhibitor of insect calcium channel.
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Monatepil maleate
0 ImagesCat. No.: HY-106818ACAS No.: 103379-03-9Synonyms: AJ-2615Monatepil maleate (AJ-2615) is a potent and orally active Ca2+-channel antagonist and a noncompetitive ACAT inhibitor. Monatepil maleate decreases blood pressure and improves plasma lipid metabolism. Monatepil maleate has the potential for the research of hyperlipidemia.
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Hyperforin dicyclohexylammonium salt (Standard)
0 ImagesCat. No.: HY-116330ARCAS No.: 238074-03-8Synonyms: Hyperforin DCHA (Standard)Hyperforin dicyclohexylammonium salt (Standard) is the analytical standard of Hyperforin dicyclohexylammonium salt. This product is intended for research and analytical applications. Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
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Etiracetam-d3
0 ImagesCat. No.: HY-B0106ASCAS No.: 2714408-84-9Synonyms: UCB 6474-d3Etiracetam-d3 is the deuterium labeled Etiracetam. Etiracetam (UCB 6474) is an acetylcholine agonist and a nootropic drug of the racetam family. Less active than its S-enantiomer Levetiracetam (UCB L059).
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F-0401
0 ImagesCat. No.: HY-177598CAS No.: 123852-99-3F-0401 is a calcium antagonist with platelet-activating factor receptor (PAFR) antagonistic action. F-0401 can be used for the research of neurological disease, such as stroke.
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Semotiadil
0 ImagesCat. No.: HY-121690CAS No.: 116476-13-2Synonyms: SD-3211Semotiadil (SD-3211), a benzothiazine compound, is a Ca2+ antagonist. Semotiadil exerts antiplatelet activity.
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XAT-13
0 ImagesCat. No.: HY-181891CAS No.: 3107904-58-2XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases.
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NMDAR blocker 1
0 ImagesCat. No.: HY-131691CAS No.: 76991-05-4NMDAR blocker 1 is an NMDA receptor channel blocker with an IC50 of 5.0 μM. NMDAR blocker 1 exhibits fast on-off blockade kinetics and strong voltage dependence, and does not compete with glutamate or glycine. NMDAR blocker 1 prevents glutamate/NMDA-induced intracellular Ca2+ overload, modulates the glutamate-nitric oxide-cGMP pathway. NMDAR blocker 1 prevents in vitro excitotoxic neurodegeneration of cultured cerebellar and hippocampal neurons. NMDAR blocker 1 attenuates excitotoxic insult in an mouse model of hyperammonemia-induced excitotoxicity. NMDAR blocker 1 can be used for the research of neurodegenerative diseases.
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ω-Hexatoxin-Hv1a
0 ImagesCat. No.: HY-P5142CAS No.: 193981-10-1Synonyms: ω-ACTX-Hv1; ω-Atracotoxin-HV1ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a blocks L-type voltage-dependent Ca2+ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons.
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UK 52831
0 ImagesCat. No.: HY-111084CAS No.: 93118-77-5UK 52831 is a long acting dihydropyridine calcium channel antagonist. UK 52831 can be used for cardiovascular disease (such as hypertension and myocardial ischemia) and anti-inflammatory research.
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Levamlodipine hydrobromide
0 ImagesCat. No.: HY-14744CCAS No.: 865430-78-0Synonyms: (S)-Amlodipine hydrobromide; Levoamlodipine hydrobromideLevamlodipine ((S)-Amlodipine; Levoamlodipin) hydrobromide is an orally active L-type calcium channel blocker and MMP-9 modulator with high permeability and retention properties. Levamlodipine hydrobromide significantly enhances plaque stability and improves lipid profiles by reducing blood pressure, decreasing systolic blood pressure variability, and inhibiting MMP-9 expression in atherosclerotic plaques. Levamlodipine hydrobromide not only alleviates cardiac and aortic hypertrophy and prevents renal atrophy, but also produces synergistic effects in blood pressure reduction and organ protection when combined with bisoprolol (HY-129029). Levamlodipine hydrobromide exerts no significant inhibitory effect on abdominal aortic intimal hyperplasia. When excessively accumulated in the epidermis, Levamlodipine hydrobromide may induce changes in keratin structure, impair the skin barrier and trigger inflammation; long-term use further exacerbates skin irritation caused by local administration. Levamlodipine hydrobromide can be used in research related to hypertension and atherosclerosis.
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LY393615
0 ImagesCat. No.: HY-135478CAS No.: 325819-97-4Synonyms: NCC1048LY393615 (NCC1048) is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research.
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L-Ascorbic acid calcium dihydrate
0 ImagesSynonyms: L-Ascorbate calcium dihydrate; Vitamin C calcium dihydrateL-Ascorbic acid calcium dihydrate (L-Ascorbate calcium dihydrate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid calcium dihydrate inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid calcium dihydrate is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid calcium dihydrate exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.
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Leualacin
0 ImagesCat. No.: HY-P2061CAS No.: 128140-12-5Leualacin, a calcium channel blocker, can be isolated from the fungus Hapsidospora irregularis.
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Semotiadil recemate fumarate
0 ImagesCat. No.: HY-U00026CAS No.: 123388-25-0Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel vasoselective Ca2+ channel antagonist.
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UK51656
0 ImagesCat. No.: HY-101707CAS No.: 88150-59-8UK51656 is a calcium antagonist with IC50 of 4 nM.
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WU-07047
0 ImagesCat. No.: HY-120816CAS No.: 1702378-78-6
