Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1258)
Related Products (1258)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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L-Ascorbic acid calcium dihydrate
0 ImagesSynonyms: L-Ascorbate calcium dihydrate; Vitamin C calcium dihydrateL-Ascorbic acid calcium dihydrate (L-Ascorbate calcium dihydrate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid calcium dihydrate inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid calcium dihydrate is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid calcium dihydrate exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.
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Leualacin
0 ImagesCat. No.: HY-P2061CAS No.: 128140-12-5Leualacin, a calcium channel blocker, can be isolated from the fungus Hapsidospora irregularis.
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Semotiadil recemate fumarate
0 ImagesCat. No.: HY-U00026CAS No.: 123388-25-0Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel vasoselective Ca2+ channel antagonist.
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UK51656
0 ImagesCat. No.: HY-101707CAS No.: 88150-59-8UK51656 is a calcium antagonist with IC50 of 4 nM.
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WU-07047
0 ImagesCat. No.: HY-120816CAS No.: 1702378-78-6
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Amlodipine-d9 maleate
0 ImagesCat. No.: HY-B0317AS1Amlodipine-d9 maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
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Nisoldipine-d3
0 ImagesCat. No.: HY-17402S3CAS No.: 1432057-47-0Synonyms: BAY-k 5552-d3Nisoldipine-d3 is deuterated labeled Nisoldipine (HY-17402). Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.
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Dronedarone-d6 hydrochloride
0 ImagesCat. No.: HY-A0016SCAS No.: 1329809-23-5Dronedarone-d6 (hydrochloride) is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4.
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ONO-2921
0 ImagesCat. No.: HY-182351CAS No.: 253306-39-7ONO-2921 is an orally active and selective N-type calcium channel blocker. ONO-2921 functionally blocks N-type calcium channels. ONO-2921 reduces paw withdrawal responses during persistent nociception and hyperalgesia to heat in neuropathic pain models. ONO-2921 can be used for research on neuropathic pain and nociceptive pain.
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T-Type calcium channel inhibitor 2
0 ImagesCat. No.: HY-147708CAS No.: 2771965-57-0T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively.
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Flosatidil
0 ImagesCat. No.: HY-164648CAS No.: 113593-34-3Synonyms: SL 85-1016Flosatidil (SL 85.1016) is an orally active Calcium Channel antagonist. Flosatidil has antianginal and antihypertensive properties.
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2'-O-Methyl Uridine-d3
0 ImagesCat. No.: HY-167925S2'-O-Methyl Uridine-d3 is the deuterium labeled Rec 15/2615 (HY-167925). Rec 15/2615 is a potent α(1)-adrenergic agonist that stimulates small cholangiocyte proliferation through the activation of calcium-dependent signaling pathways.
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GW7845
0 ImagesCat. No.: HY-121746CAS No.: 196809-22-0GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells.
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Lomerizine
0 ImagesCat. No.: HY-B0768CAS No.: 101477-55-8Synonyms: KB-2796 free baseLomerizine is an antagonist of L- and T-type voltagegated calcium channels.
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LQFM020
0 ImagesCat. No.: HY-173618CAS No.: 1431459-41-4LQFM020 is an orally active pyrazole derivative. LQFM020 inhibits Ca+ and activates K+ and NO/cGMP channels to inhibit vasoconstriction. LQFM020 has anti-inflammatory and anti-analgesic activities.
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rel-(E)-6,7-Transdihydroxyligustilide
0 ImagesCat. No.: HY-N18114CAS No.: 162426-22-4rel-(E)-6,7-Transdihydroxyligustilide is a compound found in the dried tuberous roots of Polygonum multiflorum. rel-(E)-6,7-Transdihydroxyligustilide inhibits Ca2+‑ATPase in calmodulin-deficient human erythrocyte membranes. rel-(E)-6,7-Transdihydroxyligustilide is used for the research of hyperlipidemia.
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Amlodipine aspartic acid impurity (Standard)
0 ImagesCat. No.: HY-128696RCAS No.: 400602-35-9Synonyms: Amlodipine aspartate (Standard)Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension.
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Levamlodipine gentisate
0 ImagesCat. No.: HY-129244CAS No.: 856256-16-1Synonyms: (S)-Amlodipine gentisate; Levoamlodipine gentisateLevamlodipine gentisate ((S)-Amlodipine gentisate) is a pharmacologically active amino ester with calcium channel blocker activity. Levamlodipine gentisate is used as an antihypertensive and antianginal compound. The enantiomeric purity of levamlodipine gentisate can be determined by a fast capillary electrophoresis method. The highest resolution of levamlodipine gentisate reached 9.8, indicating its potential application in compound analysis.
