Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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Taccalonolide Q
0 ImagesCat. No.: HY-N17209CAS No.: 488791-19-1Taccalonolide Q is a natural steroid.
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3,3',5,5'-Tetramethoxy-7,9':7',9-diepoxylignan-4,4'-di-O-β-D-glucopyranoside
0 ImagesCat. No.: HY-N17643CAS No.: 96038-87-83,3',5,5'-Tetramethoxy-7,9':7',9-diepoxylignan-4,4'-di-O-β-D-glucopyranoside is a natural product that can be found in tulip tree.
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Dedimethyl MitoCur-1
0 ImagesCat. No.: HY-184665CAS No.: 1638811-35-4Dedimethyl MitoCur-1 is a mitochondria-targeted curcuminoid derived from MitoCur-1 (HY-150228) with anticancer activity. MitoCur-1 induces massive reactive oxygen species production in cancer cells, reduces mitochondrial membrane potential, and triggers cell cycle arrest and apoptosis. Meanwhile, MitoCur-1 inhibits the phosphorylation of Akt and STAT3, enhances ERK phosphorylation, and upregulates the expression of the pro-apoptotic protein BNIP3. Dedimethyl MitoCur-1 can be used in research related to breast cancer, cervical cancer, prostate cancer, and neuroblastoma.
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AMPK/mTOR modulator-1
0 ImagesCat. No.: HY-181059CAS No.: 1190602-80-2AMPK/mTOR modulator-1, Ginsenoside derivative, is an orally active mTOR inhibitor and AMPK activator. AMPK/mTOR modulator-1 activates AMPK signaling with a Kd of 4.759 μM. AMPK/mTOR modulator-1 promotes M1-like tumor-associated macrophage polarization while suppressing M2-like polarization. AMPK/mTOR modulator-1 can enhance glycolysis. AMPK/mTOR modulator-1 significantly inhibits tumor progression and shows anti-inflammation activity. AMPK/mTOR modulator-1 can be used for the research of colorectal cancer.
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Xanthone V1a
0 ImagesCat. No.: HY-N10985CAS No.: 103450-96-0Xanthone V1a, a derivative of Xanthone (HY-N0126), is an antioxidant that can be found in the roots of Cudrania tricuspidata and twig extracts of Maclura fruticosa. Xanthone V1a exerts cytotoxic effects against colon, hepatocellular, and gastric carcinoma cells. Xanthone V1a exhibits scavenging activitys against DPPH and ABTS. Xanthone V1a can be used for the research of colon carcinoma, hepatocellular carcinoma, and gastric carcinoma.
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Rubiarbonol L
0 ImagesCat. No.: HY-N17644CAS No.: 142778-13-0Rubiarbonol L is an arborinane-type triterpenoid found in the roots of Rubia yunnanensis.
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Lenampicillin
0 ImagesCat. No.: HY-122412CAS No.: 86273-18-9Lenampicillin is an active compound.
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Divaricatacid
0 ImagesCat. No.: HY-N17726CAS No.: 1049708-16-8Divaricatacid is a cimifugin derivative (linear dihydrofurochromone-class compound) that can be found in Actaea species, excluding A. racemosa, A. americana, A. laciniata, and A. podocarpa. Divaricatacid serves as a chemical marker to distinguish Actaea species other than A. racemosa from authentic black cohosh (A. racemosa) products.
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AT-112
0 ImagesCat. No.: HY-101045CAS No.: 139047-55-5AT-112 is a ketotanserin analogue. AT-112 has hemodynamic effects. AT-112 significantly reduces portal vein branch blood flow and portal vein pressure. AT-112 can be used to study the pathogenesis of portal hypertension.
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Carnosol analog 1
0 ImagesCat. No.: HY-178999Carnosol analog 1 (Compound 10) is a derivative of carnosol. Carnosol analog 1 attenuates myotube atrophy (67.08% reversal) and adipocyte lipolysis in C26 tumor-conditioned models. Carnosol analog 1 alleviates cachexia-related weight loss without altering tumor progression in C26 tumor-bearing mice. Carnosol analog 1 can be used for the study of cancer cachexia.
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1β-OH Glycine DCA
0 ImagesCat. No.: HY-171117CAS No.: 111929-13-6Synonyms: 1β-Hydroxyglycodeoxycholic acid1β-OH Glycine DCA (Compound Glyco 1β,3α,12α-triol) is a bile acid derivative.
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LG 6-101
0 ImagesCat. No.: HY-117712CAS No.: 132798-26-6LG 6-101 is an orally active antiarrhythmic agent. LG 6-101 shows strong antiarrhythmic effects in a coronary-artery-ligation model of rats, better than Propafenone (HY-B0432). LG 6-101 also delays the occurence of ventricular premature beat (VPB)'s and has protective effects against cardiac arrest caused by aconitine.
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ANA-975
0 ImagesCat. No.: HY-19844CAS No.: 847453-47-8ANA975, 5-amino-3-β -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, is an oral prodrug of the TLR-7 agonist Isatoribine (HY-13655A). ANA975 is converted to Isatoribine via a combined mechanism of hydrolysis by esterases and oxidation by aldehyde oxidase. ANA975 can be used in the research of hepatitis C virus infection.
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Rivasterat
0 ImagesCat. No.: HY-159830CAS No.: 2446590-96-9Rivasterat is a cholesterol-derived steroid with anti-inflammatory activity.
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Inonotsutriol B
0 ImagesCat. No.: HY-N17283CAS No.: 1078127-80-6Inonotsutriol B is a natural product that can be found in gourd.
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Aesculioside G
0 ImagesCat. No.: HY-N16858CAS No.: 254896-70-3Aesculioside G is a natural triterpene.
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8-Keto-berberine
0 ImagesCat. No.: HY-N6957CAS No.: 81397-08-28-Keto-berberine (compound 29) is a non-naturally occurring 11, 12-oxygenated protoberberine derived from naturally occurring 9, 10-oxygenated protoberberine.
